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8-AMINOGUANINE

CAS No.:
28128-41-8
Catalog Number:
AG00BE4H
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00BE4H
Chemical Name:
8-AMINOGUANINE
CAS Number:
28128-41-8
MDL Number:
MFCD07367617
IUPAC Name:
2,8-diamino-1,7-dihydropurin-6-one
InChI:
InChI=1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12)
InChI Key:
WYDKPTZGVLTYPG-UHFFFAOYSA-N
UNII:
K158TXW61R
NSC Number:
23170
Properties
Complexity:
250  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
166.06g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
166.144g/mol
Monoisotopic Mass:
166.06g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
122A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.4  
Literature
Title Journal
Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic1-Nitropropane in F344 Rats. Journal of toxicologic pathology 20111201
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. Applied microbiology and biotechnology 20111101
Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplex. Biophysical journal 20111019
Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line. Chinese medicine 20110101
Structural properties of g,t-parallel duplexes. Journal of nucleic acids 20100101
Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes. Journal of the American Chemical Society 20091104
Evidence of strong hydrogen bonding by 8-aminoguanine. Chemical communications (Cambridge, England) 20090214
8-Amino guanine accelerates tetramolecular G-quadruplex formation. Chemical communications (Cambridge, England) 20080707
Specificity of stimulation of human 8-oxoguanine-DNA glycosylase by AP endonuclease. Biochemical and biophysical research communications 20080328
[NO-dependent modifications of nucleic acids]. Bioorganicheskaia khimiia 20070101
Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression. Nitric oxide : biology and chemistry 20060301
Destabilization of quadruplex DNA by 8-aminoguanine. Chembiochem : a European journal of chemical biology 20060101
Hemoprotein-mediated reduction of nitrated DNA bases in the presence of reducing agents. Free radical biology & medicine 20030115
Properties