Home Other Building Blocks N2-METHYLGUANOSINE

N2-METHYLGUANOSINE

CAS No.:
2140-77-4
Catalog Number:
AG00BDVE
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.2673
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Product Description
Catalog Number:
AG00BDVE
Chemical Name:
N2-METHYLGUANOSINE
CAS Number:
2140-77-4
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.2673
MDL Number:
MFCD00057039
IUPAC Name:
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(methylamino)-1H-purin-6-one
InChI:
InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10-/m1/s1
InChI Key:
SLEHROROQDYRAW-KQYNXXCUSA-N
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NC)[nH]c2=O
Properties
Complexity:
460  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
297.107g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
297.271g/mol
Monoisotopic Mass:
297.107g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
141A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.5  
Literature
Title Journal
Trmt112 gene expression in mouse embryonic development. Acta histochemica et cytochemica 20120426
The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N²-methylguanosine at position 6 in tRNA. RNA (New York, N.Y.) 20120401
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine. Biochemistry 20111213
Conformational preferences of modified nucleoside N(2)-methylguanosine (m(2)G) and its derivative N(2), N(2)-dimethylguanosine (m(2)(2)G) occur at 26th position (hinge region) in tRNA. Cell biochemistry and biophysics 20111201
Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. PloS one 20110101
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS genetics 20101201
Targeted serum metabolite profiling of nucleosides in esophageal adenocarcinoma. Rapid communications in mass spectrometry : RCM 20101030
Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. BMC plant biology 20100101
Synthesis and characterization of modified nucleotides in the 970 hairpin loop of Escherichia coli 16S ribosomal RNA. Bioorganic & medicinal chemistry 20090815
A fast capillary electrophoresis method for separation and quantification of modified nucleosides in urinary samples. Analytical chemistry 20090801
Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana. BMC genomics 20090101
In Silico screening for functional candidates amongst hypothetical proteins. BMC bioinformatics 20090101
Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. British journal of cancer 20060605
Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. BMC evolutionary biology 20060101
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