Home Other Building Blocks LASALOCID A SODIUM SALT

LASALOCID A SODIUM SALT

CAS No.:
25999-20-6
Catalog Number:
AG00BDBZ
Molecular Formula:
C34H53NaO8
Molecular Weight:
612.7696
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
97%
1 week
United States
$140
- +
50mg
97%
1 week
United States
$173
- +
100mg
97%
1 week
United States
$240
- +
Product Description
Catalog Number:
AG00BDBZ
Chemical Name:
LASALOCID A SODIUM SALT
CAS Number:
25999-20-6
Molecular Formula:
C34H53NaO8
Molecular Weight:
612.7696
MDL Number:
MFCD00078065
IUPAC Name:
sodium;6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-3-methyloxolan-2-yl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoate
InChI:
InChI=1S/C34H54O8.Na/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39;/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39);/q;+1/p-1/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+;/m1./s1
InChI Key:
RDHDUYAKDYQPEW-HWLWSTNVSA-M
SMILES:
CC[C@@H](C(=O)[C@H]([C@H]([C@@H](CCc1ccc(c(c1C(=O)[O-])O)C)C)O)C)[C@H]1O[C@](C[C@@H]1C)(CC)[C@H]1CC[C@]([C@@H](O1)C)(O)CC.[Na+]
EC Number:
247-400-3
UNII:
W2S5C71Y3G
Properties
Complexity:
917  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
612.364g/mol
Formal Charge:
0
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
612.78g/mol
Monoisotopic Mass:
612.364g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
136A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Structural characterization of polyketides using high mass accuracy tandem mass spectrometry. Analytical chemistry 20121016
Assessment of dietary supplementation with probiotics on performance, intestinal morphology and microflora of chickens infected with Eimeria tenella. Veterinary parasitology 20120813
Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis. Journal of the American Chemical Society 20120502
Biochemistry: favouring the unfavoured. Nature 20120314
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature 20120304
Determination of lasalocid residues in the tissues of broiler chickens by liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
Acute and long-term cardiomyopathy and delayed neurotoxicity after accidental lasalocid poisoning in horses. Journal of veterinary internal medicine 20120101
Tissue Doppler imaging and 2-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid. Journal of veterinary internal medicine 20120101
Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
Determination of narasin and monensin in bovine, swine, and chicken tissues by liquid chromatography with tandem mass spectrometry: first action 2011.24. Journal of AOAC International 20120101
Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry. Journal of AOAC International 20120101
Insights into lasalocid A ring formation by chemical chain termination in vivo. Angewandte Chemie (International ed. in English) 20111209
Acute lasalocid poisoning in calves associated with off-label use. Journal of veterinary pharmacology and therapeutics 20110401
Pediococcus acidilactici isolated from the rumen of lambs with rumen acidosis, 16S rRNA identification and sensibility to monensin and lasalocid. Research in veterinary science 20110201
Identification of clinically used drugs that activate pregnane X receptors. Drug metabolism and disposition: the biological fate of chemicals 20110101
Lasalocid awareness and sampling in Scotland. International journal of environmental health research 20100601
Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A. Organic letters 20100521
Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Bioscience, biotechnology, and biochemistry 20090101
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European journal of chemical biology 20081215
Efficacy of lasalocid against coccidiosis in Chinese ring-necked pheasants. Avian diseases 20081201
Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis. Journal of the American Chemical Society 20080917
Doubly compensated multiplicity-edited HSQC experiments utilizing broadband inversion pulses. Magnetic resonance in chemistry : MRC 20080701
Determination of lasalocid sodium in animal feeds and premixes by reversed-phase liquid chromatography: collaborative study. Journal of AOAC International 20080101
Effects of lasalocid or monensin supplementation on digestion, ruminal fermentation, blood metabolites, and milk production of lactating dairy cows. Journal of dairy science 20071201
Sorption and degradation in soils of veterinary ionophore antibiotics: monensin and lasalocid. Environmental toxicology and chemistry 20070801
Mucosal mast cell proteases are involved in colonic permeability alterations and subsequent bacterial translocation in endotoxemic rats. Shock (Augusta, Ga.) 20070701
Changes in net portal nutrient flux in response to weaning transition and ionophore supplementation in dairy calves. Journal of dairy science 20070301
Effects of weaning and ionophore supplementation on selected blood metabolites and growth in dairy calves. Journal of dairy science 20060901
Efficacy of ionophores in cattle diets for mitigation of enteric methane. Journal of animal science 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Simultaneous determination of four coccidiostats in eggs and broiler meat: validation of an LC-MS/MS method. Food additives and contaminants 20060501
Incidence of residues of nine anticoccidials in eggs. Food additives and contaminants 20051101
The solution structure of a lasalocid A metal complex in lipophilic solvents. Bioorganic & medicinal chemistry 20050901
[Cryptosporidiosis in newborn calves in Ankara region: clinical, haematological findings and treatment with Lasalocid-NA]. DTW. Deutsche tierarztliche Wochenschrift 20050601
A band-selective composite gradient: application to DQF-COSY. Journal of magnetic resonance (San Diego, Calif. : 1997) 20050501
A comparison of data analysis methods for determining gas phase stabilities by CID: alkali metal complexes of polyether ionophore antibiotics. Journal of the American Society for Mass Spectrometry 20050501
Periodicity in collision-induced and remote-bond activation of alkali metal ions attached to polyether ionophores. The Analyst 20050401
Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
Extending the limits of the selective 1D NOESY experiment with an improved selective TOCSY edited preparation function. Journal of magnetic resonance (San Diego, Calif. : 1997) 20041201
Ionophore taste preferences of dairy heifers. Journal of animal science 20041101
Production and health of pasture-fed dairy cattle following oral treatment with the ionophore lasalocid. Journal of dairy science 20040901
Accidental poisoning of 17 dogs with lasalocid. The Veterinary record 20040807
[Development of monoclonal-based enzyme-linked immunosorbent assay and immunochromatographic assay for lasalocid and semduramicin]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20040601
Isolation and selection of ionophore-tolerant Eimeria precocious lines: E. tenella, E. maxima and E. acervulina. Veterinary parasitology 20040206
An alternative to antibiotic-based drugs in feed for enhancing performance of broilers grown on Eimeria spp.-infected litter. Poultry science 20040101
Rapid forensic selected reaction monitoring liquid chromatography/mass spectrometry determination of ionophore antibiotics found at toxic levels in animal feeds. Journal of AOAC International 20040101
Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. Avian diseases 20040101
Effect of lasalocid on growth, blood gases, and nutrient utilization in dairy goats fed a high forage, low protein diet. Journal of dairy science 20031201
Suspected lasalocid poisoning in three dogs. Veterinary and human toxicology 20031001
Guanidinium receptors as enantioselective amino acid membrane carriers. Journal of the American Chemical Society 20030709
Effects of lasalocid on circulating concentrations of leptin and insulin-like growth factor-I and reproductive performance of postpartum Brahman cows. Journal of animal science 20030601
Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella. Archiv fur Tierernahrung 20030401
Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro. Journal of applied microbiology 20030101
Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations. Biopolymers 20021015
[Effects of veterinary drugs on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20021001
Fragmentation studies on lasalocid acid by accurate mass electrospray mass spectrometry. The Analyst 20020901
Use of an adsorbed chiral selector in capillary LC-MS. Chirality 20020801
Lasalocid toxicosis is inadequately quantified for horses. Veterinary and human toxicology 20020801
Effect of lonophore supplementation on selected serum constituents of sheep consuming locoweed. Veterinary and human toxicology 20020601
Improved clean-up for the determination of lasalocid in 'difficult' food matrices. Food additives and contaminants 20020101
Effects of dietary rice bran, lasalocid, and sex of calf on postpartum reproduction in Brahman cows. Journal of animal science 20011201
Secretion of the trefoil factor TFF3 from the isolated vascularly perfused rat colon. Regulatory peptides 20010915
Nutritionally directed compensatory growth enhances heifer development and lactation potential. Journal of dairy science 20010701
7Li-NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution. Biopolymers 20010101
LC/MS confirmation of ionophores in animal feeds. Journal of AOAC International 20010101
Interaction of fluoroquinolones and certain ionophores in broilers: effect on blood levels and hepatic cytochrome p450 monooxygenase activity. Drug metabolism and drug interactions 20010101
Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. The Journal of antimicrobial chemotherapy 20000301
In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum. The Journal of antimicrobial chemotherapy 19980201
Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. Antimicrobial agents and chemotherapy 19970101
Putative anticryptosporidial agents tested with an immunodeficient mouse model. Antimicrobial agents and chemotherapy 19940401
Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats. The Journal of infectious diseases 19931201
Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice. The Journal of protozoology 19910101
Properties