2-DEOXYSTREPTAMINE, DIHYDROBROMIDE
| Title | Journal |
|---|---|
| Radical SAM enzymes in the biosynthesis of sugar-containing natural products. | Biochimica et biophysica acta 20121101 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Nature chemical biology 20111009 |
| Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond. | Bioorganic & medicinal chemistry letters 20110815 |
| Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. | PLoS neglected tropical diseases 20110501 |
| Influence of charge and structure on the coordination chemistry of copper aminoglycosides. | Dalton transactions (Cambridge, England : 2003) 20110227 |
| Biosynthetic approach for the production of new aminoglycoside derivative. | Journal of bioscience and bioengineering 20100701 |
| Thermodynamics and kinetics of association of antibiotics with the aminoglycoside acetyltransferase (3)-IIIb, a resistance-causing enzyme. | Biochemistry 20100518 |
| Interactions of coenzyme A with the aminoglycoside acetyltransferase (3)-IIIb and thermodynamics of a ternary system. | Biochemistry 20100518 |
| Biosynthesis of paromamine derivatives in engineered Escherichia coli by heterologous expression. | Journal of applied microbiology 20100501 |
| Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. | PloS one 20100101 |
| Development of a multicommutated flow system with chemiluminometric detection for quantification of gentamicin in pharmaceuticals. | Journal of automated methods & management in chemistry 20100101 |
| Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions. | Viruses 20091201 |
| Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations. | Organic & biomolecular chemistry 20091021 |
| Asymmetric desymmetrization of 4,5-epoxycyclohex-1-ene by enantioselective allylic oxidation. | Organic letters 20090806 |
| Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853. | Molecules and cells 20090531 |
| Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics. | Perspectives in medicinal chemistry 20090101 |
| Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily. | Cellular and molecular life sciences : CMLS 20081201 |
| The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. | Organic & biomolecular chemistry 20080921 |
| Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. | Biochemistry 20080826 |
| A convenient synthesis of orthogonally protected 2-deoxystreptamine (2-DOS) as an aminocyclitol scaffold for the development of novel aminoglycoside antibiotic derivatives against bacterial resistance. | Organic & biomolecular chemistry 20080821 |
| Fully orthogonally protected 2-deoxystreptamine from kanamycin. | The Journal of organic chemistry 20080704 |
| Improved liquid chromatographic method with pulsed electrochemical detection for the analysis of gentamicin. | Journal of chromatography. A 20080502 |
| Heterologous production and detection of recombinant directing 2-deoxystreptamine (DOS) in the non-aminoglycoside-producing host Streptomyces venezuelae YJ003. | Journal of microbiology and biotechnology 20080501 |
| Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+. | Proteins 20080201 |
| Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. | Journal of the American Chemical Society 20071212 |
| Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. | Bioorganic & medicinal chemistry 20070601 |
| Modifications of aminoglycoside antibiotics targeting RNA. | Medicinal research reviews 20070501 |
| A short and scalable route to orthogonally O-protected 2-deoxystreptamine. | The Journal of organic chemistry 20070427 |
| Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. | Natural product reports 20061201 |
| Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity. | Biochemistry 20060912 |
| Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group. | Biochimie 20060801 |
| Exploration of genes that encode a carbocycle-forming enzyme involved in biosynthesis of aminoglycoside antibiotics from the environmental DNA. | Bioscience, biotechnology, and biochemistry 20060701 |
| Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. | The Journal of antibiotics 20051201 |
| Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes. | Bioorganic & medicinal chemistry 20051115 |
| The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides. | Bioorganic & medicinal chemistry letters 20051115 |
| Size-specific ligands for RNA hairpin loops. | Journal of the American Chemical Society 20050914 |
| Synthesis of a library of stereo- and regiochemically diverse aminoglycoside derivatives. | Organic & biomolecular chemistry 20050807 |
| Crystallization and X-ray analysis of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. | Acta crystallographica. Section F, Structural biology and crystallization communications 20050701 |
| Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073. | The Journal of antibiotics 20050601 |
| Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis. | Journal of the American Chemical Society 20050427 |
| The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. | Organic & biomolecular chemistry 20050421 |
| Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. | Bioorganic chemistry 20050401 |
| 2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics. | Chemical reviews 20050301 |
| A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics. | Journal of the American Chemical Society 20050216 |
| Characterization of L-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius. | Bioorganic & medicinal chemistry letters 20050103 |
| Thermodynamics of aminoglycoside binding to aminoglycoside-3'-phosphotransferase IIIa studied by isothermal titration calorimetry. | Biochemistry 20041123 |
| Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835. | Molecules and cells 20040831 |
| Efficient preparation of a 1,3-diazidocyclitol as a versatile 2-deoxystreptamine precursor. | The Journal of organic chemistry 20040625 |
| Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome. | Bioorganic & medicinal chemistry letters 20040209 |
| Active site mapping of 2-deoxy-scyllo-inosose synthase, the key starter enzyme for the biosynthesis of 2-deoxystreptamine. Mechanism-based inhibition and identification of lysine-141 as the entrapped nucleophile. | The Journal of organic chemistry 20040206 |
| An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius. | Biotechnology letters 20031201 |
| Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry. | Bioorganic & medicinal chemistry letters 20031117 |
| Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site. | Chembiochem : a European journal of chemical biology 20030905 |
| Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity. | Inorganic chemistry 20030310 |
| Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine. | Chemical communications (Cambridge, England) 20021207 |
| Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA. | Bioorganic & medicinal chemistry letters 20021202 |
| First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics--genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inosose aminotransferase genes. | The Journal of antibiotics 20021101 |
| Identification of L-glutamine: 2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans. | The Journal of antibiotics 20020801 |
| Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans. | Bioscience, biotechnology, and biochemistry 20020701 |
| Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. | The Journal of organic chemistry 20020614 |
| Sequence-specific recognition of the major groove of RNA by deoxystreptamine. | Biochemistry 20020521 |
| An efficient synthesis of mimetics of neamine for RNA recognition. | Organic letters 20010531 |
| Study of aminoglycoside-nucleic acid interactions by an HPLC method. | Bioorganic & medicinal chemistry letters 20010423 |
| In-vitro activities of aminoglycoside-aminocyclitols against mycobacteria. | The Journal of antimicrobial chemotherapy 19970701 |