3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Title | Journal |
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Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. | Toxicology 20160831 |
Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases. | Environmental health perspectives 20160601 |
Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction. | PloS one 20160101 |
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. | The Journal of biological chemistry 20150529 |
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells. | Cell death & disease 20140801 |
Cell-based assays for Parkinson's disease using differentiated human LUHMES cells. | Acta pharmacologica Sinica 20140701 |
Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells. | Toxicology 20140605 |
Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. | The Journal of biological chemistry 20140418 |
Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death. | Cell death & disease 20140301 |
PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium. | Archives of toxicology 20140201 |
3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. | Toxicology and applied pharmacology 20131101 |
The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | Toxicology letters 20130412 |
A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. | PloS one 20130101 |
Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. | Journal of medicinal chemistry 20121108 |
IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway. | Journal of cellular biochemistry 20121101 |
WNT/β-catenin-signaling pathway stimulates the proliferation of cultured adult human Sertoli cells via upregulation of C-myc expression. | Reproductive sciences (Thousand Oaks, Calif.) 20121101 |
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. | FEBS letters 20121019 |
Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling. | Toxicology and applied pharmacology 20121015 |
Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: possible involvement of HSP 72. | Molecular and cellular biochemistry 20121001 |
Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. | Biochemical and biophysical research communications 20120914 |
Roles of glycogen synthase kinase 3 in Alzheimer's disease. | Current Alzheimer research 20120901 |
Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury. | Journal of veterinary science 20120901 |
Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3β/β-catenin signaling pathway in ischemic rat myocardium. | Shock (Augusta, Ga.) 20120801 |
Wnt3a upregulates prostaglandin F2α-stimulated vascular endothelial growth factor synthesis in osteoblasts. | Molecular medicine reports 20120801 |
GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells. | Molecular cancer research : MCR 20120801 |
Glycogen synthase kinase 3β (GSK3β) modulates antiviral activity of zinc-finger antiviral protein (ZAP). | The Journal of biological chemistry 20120629 |
Acute inhibition of GSK causes mitochondrial remodeling. | American journal of physiology. Heart and circulatory physiology 20120601 |
Inhibition of GSK-3beta ameliorates hepatic ischemia-reperfusion injury through GSK-3beta/beta-catenin signaling pathway in mice. | Hepatobiliary & pancreatic diseases international : HBPD INT 20120601 |
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523 |
Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse. | Behavioural brain research 20120516 |
Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells. | Neurotoxicity research 20120401 |
Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine. | Schizophrenia research 20120401 |
Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. | Blood 20120308 |
Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. | Carcinogenesis 20120301 |
Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors. | Oncogene 20120209 |
Phosphorylation of Akt/GSK-3β/eNOS amplifies 5-HT2B receptor blockade mediated anti-hypertrophic effect in rats. | FEBS letters 20120120 |
A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. | Toxicology and applied pharmacology 20120115 |
Muscle FBPase binds to cardiomyocyte mitochondria under glycogen synthase kinase-3 inhibition or elevation of cellular Ca2+ level. | FEBS letters 20120102 |
Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. | Biological & pharmaceutical bulletin 20120101 |
Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells. | PloS one 20120101 |
Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis. | PloS one 20120101 |
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania. | The international journal of neuropsychopharmacology 20110901 |
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. | The Biochemical journal 20110715 |
Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory. | Journal of neurochemistry 20110701 |
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation. | Oncogene 20110526 |
GSK3β inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility. | American journal of physiology. Renal physiology 20110501 |
Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β. | European journal of pharmacology 20110425 |
The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue. | Experimental dermatology 20110301 |
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production. | Journal of neurochemistry 20110301 |
Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics. | Neuroscience 20110203 |
The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3). | Bioorganic & medicinal chemistry letters 20110101 |
RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. | PloS one 20110101 |
Dendritic cell maturation occurs through the inhibition of GSK-3β. | Cellular immunology 20110101 |
AP-1 is a component of the transcriptional network regulated by GSK-3 in quiescent cells. | PloS one 20110101 |
Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling. | Cell & bioscience 20110101 |
Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta. | PloS one 20110101 |
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. | PloS one 20110101 |
Inhibition of glycogen synthase kinase-3β counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer. | PloS one 20110101 |
Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis. | Neuropharmacology 20101101 |
Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. | Molecular cell 20101008 |
Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. | Bioorganic & medicinal chemistry 20100915 |
Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. | Cellular and molecular neurobiology 20100801 |
{beta}-Catenin regulates airway smooth muscle contraction. | American journal of physiology. Lung cellular and molecular physiology 20100801 |
Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes. | Clinical and experimental pharmacology & physiology 20100701 |
Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630 |
4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. | Journal of cellular and molecular medicine 20100601 |
Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload. | Cardiovascular research 20100601 |
Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase. | American journal of physiology. Lung cellular and molecular physiology 20100601 |
Effects of areca nut extract on the apoptosis pathways in human neutrophils. | Journal of periodontal research 20100601 |
Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1. | Journal of neurochemistry 20100601 |
Inhibition of GSK3 attenuates dopamine D1 receptor agonist-induced hyperactivity in mice. | Brain research bulletin 20100531 |
GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100421 |
Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. | Cellular and molecular neurobiology 20100301 |
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. | The Journal of pharmacology and experimental therapeutics 20100301 |
Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. | Journal of medicinal chemistry 20100211 |
A new class of molecular targeted radioprotectors: GSK-3beta inhibitors. | International journal of radiation oncology, biology, physics 20100201 |
Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70. | PloS one 20100101 |
Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes. | PloS one 20100101 |
Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice. | Vascular pharmacology 20100101 |
Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway. | Cell proliferation 20091201 |
Regulation of serotonin 1B receptor by glycogen synthase kinase-3. | Molecular pharmacology 20091201 |
Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization. | Journal of neurochemistry 20091201 |
Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. | Molecular pharmacology 20091001 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal. | Neuropharmacology 20090901 |
The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor. | Drug metabolism and disposition: the biological fate of chemicals 20090801 |
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. | European journal of medicinal chemistry 20090601 |
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. | Biochimica et biophysica acta 20090601 |
The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening. | The Journal of pharmacology and experimental therapeutics 20090601 |
Cocaine-induced hyperactivity and sensitization are dependent on GSK3. | Neuropharmacology 20090601 |
Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. | Cellular signalling 20090401 |
TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta. | American journal of physiology. Lung cellular and molecular physiology 20090401 |
Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells. | Toxicological sciences : an official journal of the Society of Toxicology 20090301 |
Knockin of mutant PIK3CA activates multiple oncogenic pathways. | Proceedings of the National Academy of Sciences of the United States of America 20090224 |
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. | Neuropharmacology 20090201 |
GSK3beta regulates differentiation and growth arrest in glioblastoma. | PloS one 20090101 |
Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. | Circulation research 20081024 |
Advanced glycation end-product-inhibited cell proliferation and protein expression of beta-catenin and cyclin D1 are dependent on glycogen synthase kinase 3beta in LLC-PK1 cells. | Archives of biochemistry and biophysics 20080901 |
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. | American journal of physiology. Cell physiology 20080901 |
Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition. | Anesthesia and analgesia 20080901 |
Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore. | The Journal of pharmacology and experimental therapeutics 20080701 |
Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful? | Neoplasia (New York, N.Y.) 20080601 |
Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763. | European journal of pharmacology 20080531 |
Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. | Circulation 20080527 |
GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption. | Journal of applied toxicology : JAT 20080501 |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore. | American journal of hypertension 20080501 |
Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. | American journal of physiology. Heart and circulatory physiology 20080301 |
Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes. | Cardiovascular toxicology 20080101 |
The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. | Journal of cellular biochemistry 20071201 |
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. | The Journal of biological chemistry 20071019 |
Media conditioned by retinal pigment epithelial cells suppress the canonical Wnt pathway. | Neuroscience letters 20070913 |
Cyclosporine A- and FK506-induced apoptosis in PC12 cells. | Cell biology and toxicology 20070901 |
Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. | Cellular and molecular neurobiology 20070901 |
GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. | Basic research in cardiology 20070701 |
Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. | Cancer letters 20070628 |
Structure based de novo design of novel glycogen synthase kinase 3 inhibitors. | Bioorganic & medicinal chemistry 20070601 |
Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis. | Biochemical and biophysical research communications 20070309 |
Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. | Molecular cancer therapeutics 20070301 |
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. | Cancer research 20070101 |
Inhibiting glycogen synthase kinase 3beta in sepsis. | Novartis Foundation symposium 20070101 |
Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis. | Journal of vascular research 20070101 |
Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. | Neuroscience letters 20061113 |
Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats. | The Journal of pharmacology and experimental therapeutics 20061101 |
The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. | Experimental cell research 20061101 |
[Glycogen synthase kinase-3beta (GSK-3beta) promotes proliferation of ovarian cancer cells in vitro]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061101 |
Modulation of key elements of the Wnt pathway by apple polyphenols. | Journal of agricultural and food chemistry 20060920 |
Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. | Journal of agricultural and food chemistry 20060920 |
Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells. | Brain research 20060919 |
A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells. | Assay and drug development technologies 20060801 |
Prevention of rat cortical neurons from prostaglandin E2-induced apoptosis by glycogen synthase kinase-3 inhibitors. | Neuroscience letters 20060529 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation. | Shock (Augusta, Ga.) 20060501 |
Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. | The Journal of biological chemistry 20060224 |
Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. | Oncogene 20060105 |
Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium. | Journal of molecular and cellular cardiology 20060101 |
The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders. | IDrugs : the investigational drugs journal 20060101 |
Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. | Cancer research 20051001 |
Glycogen synthase kinase 3 controls endochondral bone development: contribution of fibroblast growth factor 18. | Developmental biology 20050915 |
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. | Critical care medicine 20050901 |
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. | Molecular cancer therapeutics 20050901 |
Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. | Cancer research 20050715 |
Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050615 |
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. | Cancer research 20050301 |
Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium. | Neuroscience 20050101 |
Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c. | The Journal of biological chemistry 20041210 |
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. | Oncogene 20041014 |
Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons. | European journal of pharmacology 20040924 |
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells. | European journal of pharmacology 20040714 |
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. | Circulation research 20040416 |
An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B. | Oncogene 20040401 |
Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. | Biochemical and biophysical research communications 20040319 |
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. | Bioorganic & medicinal chemistry letters 20030915 |
Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity. | Neuroreport 20030806 |
Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. | The Biochemical journal 20021015 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective. | Circulation research 20020308 |
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity. | FEBS letters 20011102 |
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. | Journal of neurochemistry 20010401 |
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. | Chemistry & biology 20001001 |
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. | Diabetes 20000201 |
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. | Diabetes 19990801 |
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. | Proceedings of the National Academy of Sciences of the United States of America 19930815 |
Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor. | Molecular endocrinology (Baltimore, Md.) |