Home Other Building Blocks Levobunolol hydrochloride

Levobunolol hydrochloride

CAS No.:
27912-14-7
Catalog Number:
AG00BC9X
Molecular Formula:
C17H26ClNO3
Molecular Weight:
327.8462
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$140
- +
50mg
≥98%
1 week
United States
$153
- +
100mg
≥98%
1 week
United States
$239
- +
250mg
≥98%
1 week
United States
$440
- +
Product Description
Catalog Number:
AG00BC9X
Chemical Name:
Levobunolol hydrochloride
CAS Number:
27912-14-7
Molecular Formula:
C17H26ClNO3
Molecular Weight:
327.8462
MDL Number:
MFCD03425587
IUPAC Name:
5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride
InChI:
InChI=1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H/t12-;/m0./s1
InChI Key:
DNTDOBSIBZKFCP-YDALLXLXSA-N
SMILES:
O[C@H](COc1cccc2c1CCCC2=O)CNC(C)(C)C.Cl
EC Number:
248-725-3
UNII:
O90S49LDHH
Properties
Complexity:
350  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
327.16g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
327.849g/mol
Monoisotopic Mass:
327.16g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
58.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs. Journal of veterinary science 20110301
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma. Veterinary therapeutics : research in applied veterinary medicine 20100101
Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs. Veterinary research communications 20090901
Poly (epsilon-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: effects of some formulation parameters on microparticle characteristics. Journal of microencapsulation 20090201
An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes. European journal of ophthalmology 20080101
Vasodilatory mechanism of levobunolol on vascular smooth muscle cells. Experimental eye research 20070601
Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells. The Kaohsiung journal of medical sciences 20070301
Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol. Contact dermatitis 20070101
Membrane electrodes for determination of some beta-blocker drugs. Journal of AOAC International 20070101
Contact dermatitis to levobunolol eyedrops superimposed on IgE-mediated rhinoconjunctivitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061201
Drops and falls. Age and ageing 20061101
Allergic contact dermatitis due to levobunolol in an ophthalmic preparation. The Journal of dermatology 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Beta-blocker eye drops. Nursing times 20060501
Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells. The Kaohsiung journal of medical sciences 20060201
The effect of once-daily levobunolol on intraocular pressure in normal-tension glaucoma. Japanese journal of ophthalmology 20050101
Reversal of disc cupping after intraocular pressure reduction in topographic image series. Journal of glaucoma 20041001
Deposits in artificial corneas: risk factors and prevention. Clinical & experimental ophthalmology 20040401
Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401
Thyroid eye disease and glaucoma. Journal of glaucoma 20031201
Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface. Cornea 20031101
The effect of topical glaucoma medications evaluated by perimetry. The British journal of ophthalmology 20030601
Noninvasive assessment of aqueous humor turnover in the mouse eye. Investigative ophthalmology & visual science 20030201
A comparison of the efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD and 0.5% levobunolol hydrochloride BID in patients with ocular hypertension or open-angle glaucoma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401
Allergic reactions to brimonidine in patients treated for glaucoma. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20020201
False-negative patch test with levobunolol. Contact dermatitis 20010401
The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study. European journal of ophthalmology 20010101
Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade. Heart disease (Hagerstown, Md.) 20010101
[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]. Nippon Ganka Gakkai zasshi 19990701
Short-term effects of topical levobunolol on the human retinal circulation. Eye (London, England) 19970101
Syncope, bradycardia, and atrioventricular block associated with topical ophthalmic levobunolol. American heart journal 19940301
A comparison of the ocular hypotensive efficacy and systemic safety of 0.5% levobunolol and 2% carteolol. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101
A comparison of the ocular tolerability of a single dose of timolol and levobunolol in healthy normotensive volunteers. Annals of ophthalmology 19930401
Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 19871201
Comparison of ophthalmic beta-blocking agents. Clinical pharmacy 19870601
Levobunolol for the long-term treatment of glaucoma. General pharmacology 19860101
l-Bunolol and propranolol: oral and intravenous beta-adrenoceptor blocking activity in rats compared to dogs and humans. Journal of pharmaceutical sciences 19780101
Properties