Home Other Building Blocks Mebeverine hydrochloride

Mebeverine hydrochloride

CAS No.:
2753-45-9
Catalog Number:
AG00BBU2
Molecular Formula:
C25H35NO5
Molecular Weight:
429.5491
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00BBU2
Chemical Name:
Mebeverine hydrochloride
CAS Number:
2753-45-9
Molecular Formula:
C25H35NO5
Molecular Weight:
429.5491
MDL Number:
MFCD00083411
IUPAC Name:
4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate;hydrochloride
InChI:
InChI=1S/C25H35NO5.ClH/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5;/h9-14,18-19H,6-8,15-17H2,1-5H3;1H
InChI Key:
PLGQWYOULXPJRE-UHFFFAOYSA-N
SMILES:
COc1ccc(cc1)CC(N(CCCCOC(=O)c1ccc(c(c1)OC)OC)CC)C
EC Number:
220-400-0
Properties
Complexity:
494  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
465.228g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
466.015g/mol
Monoisotopic Mass:
465.228g/mol
Rotatable Bond Count:
14  
Topological Polar Surface Area:
57.2A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma. Chirality 20120801
Support vector regression and artificial neural network models for stability indicating analysis of mebeverine hydrochloride and sulpiride mixtures in pharmaceutical preparation: a comparative study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120201
Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201
Treatment of IBS-D with 5-HT3 receptor antagonists vs spasmolytic agents: similar therapeutical effects from heterogeneous pharmacological targets. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201
Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system. Pharmaceutical development and technology 20110801
Quality of life in patients with irritable bowel syndrome. Journal of clinical gastroenterology 20110801
Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines. Journal of pharmaceutical and biomedical analysis 20110325
[Effectiveness of duspatalin therapy in the treatment and prevention of post-cholecystectomy syndrome]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20110101
[Chronic pancreatitis: microbe-intestinal tissue complex and systemic inflammatory response]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
[Significance of biliary dysfunction in the pathogenesis of gallstone disease]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma. Journal of fluorescence 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination. European journal of medicinal chemistry 20100901
Colloids as a sink for certain pharmaceuticals in the aquatic environment. Environmental science and pollution research international 20100501
Predictors of treatment outcome after cognitive behavior therapy and antispasmodic treatment for patients with irritable bowel syndrome in primary care. Journal of psychosomatic research 20100401
A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. World journal of gastroenterology 20100207
[Modern approaches to the therapy of biliary system diseases]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101
Validated HPLC determination of the two fixed dose combinations (chlordiazepoxide hydrochloride and mebeverine hydrochloride; carvedilol and hydrochlorothiazide) in their tablets. Journal of AOAC International 20100101
Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial). BMC gastroenterology 20100101
Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115
Psychological associations of irritable bowel syndrome besides panic disorder: an often overlooked reality. Scandinavian journal of gastroenterology 20090101
[How to raise efficacy of gastroesophageal reflux disease treatment]. Terapevticheskii arkhiv 20090101
[The effectiveness of spasmolytic therapy in chronic acalculous cholecystitis]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101
[A method for non-medicamentous treatment of irritated bowel syndrome]. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20090101
Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080501
Cost-effectiveness of cognitive behaviour therapy in addition to mebeverine for irritable bowel syndrome. European journal of gastroenterology & hepatology 20080401
[Irritable bowel syndrome-an unbeloved problem]. MMW Fortschritte der Medizin 20080327
Spectrophotometric determination of benzydamine HCl, levamisole HCl and mebeverine HCl through ion-pair complex formation with methyl orange. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080301
[Efficacy of duspatalin in the treatment and prophylaxis of postcholecystectomic syndrome]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101
Colon-specific drug delivery for mebeverine hydrochloride. Journal of drug targeting 20071201
A novel formulation for mebeverine hydrochloride. Drug development and industrial pharmacy 20071001
[Drug treatment of irritable bowel syndrome: an unmet need]. Gastroenterologia y hepatologia 20070301
[Assessment of the efficacy of mebeverine in the complex therapy of chronic noncalculolis cholecystitis and biliary dysfunction]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101
Health technology assessment and ill-structured problems: a case study concerning the drug mebeverine. International journal of technology assessment in health care 20070101
[Chronic abdominal pain syndrome in biliary pathology]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101
Formulation of an antispasmodic drug as a topical local anesthetic. International journal of pharmaceutics 20061201
Cognitive behavioural therapy in addition to antispasmodic therapy for irritable bowel syndrome in primary care: randomised controlled trial. Health technology assessment (Winchester, England) 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
'My patients are the sickest'. European journal of gastroenterology & hepatology 20060501
Quality of life of patients with irritable bowel syndrome is low compared to others with chronic diseases. European journal of gastroenterology & hepatology 20060501
Investigative implications of the instability and metabolism of mebeverine. Journal of analytical toxicology 20060301
A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma. Biomedical chromatography : BMC 20060201
Generic and brand-name drugs. Are different criteria sufficiently taken into account before granting market authorisation? Acta clinica Belgica 20060101
[The pain problem as a historic aspect. Pain at the biliary pathology. Mebeverine hydrochloride as a part of complex therapy]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20060101
Mebeverine influences sodium ion transport in the distal colon. Pharmacological reports : PR 20060101
[Mebeverine for complex treatment of opisthorchiasis]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20060101
[Determination of placebo effect in irritable bowel syndrome]. Deutsche medizinische Wochenschrift (1946) 20050826
Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial. BMJ (Clinical research ed.) 20050820
Simultaneous determination of mebeverine hydrochloride and sulpiride using the first derivatives of ratio spectra and chemometric methods. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050801
A new RP-HPLC method for analysis of mebeverine hydrochloride in raw materials and tablets. Pakistan journal of pharmaceutical sciences 20050401
Potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine. Journal of pharmaceutical and biomedical analysis 20050104
Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples. Rapid communications in mass spectrometry : RCM 20050101
Treatment patterns and health care costs of mebeverine-treated IBS patients: a case-control study. Pharmacoepidemiology and drug safety 20041101
Spectrophotometric microdetermination of nefopam, mebevrine and phenylpropanolamine hydrochloride in pharmaceutical formulations using alizarins. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701
A double-blind randomised, placebo-controlled trial evaluating the influence of oral long-acting muscle relaxant (Mebeverine MR), and insufflation with CO(2) on pain associated with barium enema. European radiology 20030701
A pharmacokinetic comparison of the modified release capsule and a plain tablet formulation of mebeverine. International journal of clinical practice 20021101
Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. Journal of pharmaceutical and biomedical analysis 20020620
[Mebeverine-retard in relief of pain in gallstone patients]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20020101
[Duspatalin in functional disorders of the Oddi's sphincter in patients subjected cholecystectomy]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20020101
The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS. Journal of analytical toxicology 20010101
Properties