Home Other Building Blocks 4-Anilinobenzoic acid

4-Anilinobenzoic acid

CAS No.:
17040-20-9
Catalog Number:
AG00AUT4
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00AUT4
Chemical Name:
4-Anilinobenzoic acid
CAS Number:
17040-20-9
MDL Number:
MFCD00157014
IUPAC Name:
4-anilinobenzoic acid
InChI:
InChI=1S/C13H11NO2/c15-13(16)10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
InChI Key:
DPAMLADQPZFXMD-UHFFFAOYSA-N
NSC Number:
158046
Properties
Complexity:
228  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
213.079g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
213.236g/mol
Monoisotopic Mass:
213.079g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
49.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
Literature
Title Journal
Toxicogenomic biomarkers for renal papillary injury in rats. Toxicology 20130107
Structure-activity relationship of fenamates as Slo2.1 channel activators. Molecular pharmacology 20121101
Biomarkers of collecting duct injury in Han-Wistar and Sprague-Dawley rats treated with N-phenylanthranilic Acid. Toxicologic pathology 20120601
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. Journal of medicinal chemistry 20120308
A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells. PloS one 20120101
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells. American journal of physiology. Lung cellular and molecular physiology 20111001
Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat. Toxicological sciences : an official journal of the Society of Toxicology 20110801
Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids. Molecules (Basel, Switzerland) 20110428
Evidence for basolateral Cl- channels as modulators of apical Cl- secretion in pulmonary epithelia of Xenopus laevis. American journal of physiology. Regulatory, integrative and comparative physiology 20110301
Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3). Bioorganic & medicinal chemistry letters 20110301
Aromatic side-chain cluster of biotin binding site of avidin allows circular dichroism spectroscopic investigation of its ligand binding properties. Journal of molecular recognition : JMR 20110101
An outwardly rectifying chloride channel in BeWo choriocarcinoma cell line. Placenta 20101201
Rat parotid gland cell differentiation in three-dimensional culture. Tissue engineering. Part C, Methods 20101001
Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection. ChemMedChem 20100406
Voltage-dependent calcium and chloride currents in S17 bone marrow stromal cell line. Journal of cellular physiology 20100401
5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: a robust method to screen MAPK pathway allosteric inhibitors. Chemical communications (Cambridge, England) 20100328
The cystic fibrosis transmembrane conductance regulator and chloride-dependent ion fluxes of ovine vocal fold epithelium. Journal of speech, language, and hearing research : JSLHR 20090601
Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle. American journal of respiratory cell and molecular biology 20090201
Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture. Biology of reproduction 20090101
Functional expression of cystic fibrosis transmembrane conductance regulator in rat oviduct epithelium. Acta biochimica et biophysica Sinica 20081001
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites. Biochemistry 20080826
Spectrophotometric determination of trace iron by using its catalytic effect on the N-phenylanthranilic acid-potassium periodate reaction. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080501
Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. Biochemical pharmacology 20070515
Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release. Journal of neurophysiology 20070101
Low ambient [Cl-] increases Ca2+ mobilization and stimulates nitric oxide and prostaglandin E2 production in human bronchial epithelial cells. Lung 20070101
MRI histopathology correlation of N-phenylanthranilic acid induced nephropathy in rats. The British journal of radiology 20061201
Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta. European journal of pharmacology 20060821
Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides. Biological & pharmaceutical bulletin 20060601
Activation and inhibition of kidney CLC-K chloride channels by fenamates. Molecular pharmacology 20060101
Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels. Pflugers Archiv : European journal of physiology 20051201
The block of CFTR by scorpion venom is state-dependent. Biophysical journal 20051201
The underlying cellular mechanism in the effect of tetramethylpyrazine on the anion secretion of colonic mucosa. The Japanese journal of physiology 20051201
Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells. The Journal of physiology 20051015
Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells. American journal of physiology. Renal physiology 20051001
Duodenal secretion in humans mediated by the EP4 receptor subtype. Acta physiologica Scandinavica 20051001
Chloride efflux in unstimulated Leydig cells causes autonomous cAMP production and stimulatory/inhibitory steroidogenesis with an efflux inhibitor. Steroids 20050801
Infrared studies of the polymorphic states of the fenamates. Journal of pharmaceutical and biomedical analysis 20050309
Protein biomarkers of nephrotoxicity; a review and findings with cyclosporin A, a signal transduction kinase inhibitor and N-phenylanthranilic acid. Cancer biomarkers : section A of Disease markers 20050101
Hydroxyl radical activation of a Ca(2+)-sensitive nonselective cation channel involved in epithelial cell necrosis. American journal of physiology. Cell physiology 20041001
Functional characterization of muscarinic receptor subtypes in human duodenal secretion. Acta physiologica Scandinavica 20040901
Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 20040201
Diphenylamine-2-carboxylic acid potentiates the cyclic nucleotides-mediated relaxation of porcine coronary artery: possible involvement of the inhibitory effect on the efflux of cyclic nucleotides. Vascular pharmacology 20040201
Luminal space enlargement by carbachol in rat parotid intralobular ducts. European journal of oral sciences 20031001
Characterization of Ca2+-activated Cl- currents in mouse kidney inner medullary collecting duct cells. American journal of physiology. Renal physiology 20030801
The effect of nitric oxide on the permeability of nasal epithelial cells from healthy and asthmatic donors. Medical science monitor : international medical journal of experimental and clinical research 20030701
Calcium-activated cationic channel in rat sensory neurons. The European journal of neuroscience 20030601
A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells. The Journal of biological chemistry 20030523
Ca2+-activated Cl- channel currents in rat ventral prostate epithelial cells. The Prostate 20030501
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia. The Journal of physiology 20030401
Active NaCl absorption across posterior gills of hyperosmoregulating Chasmagnathus granulatus. The Journal of experimental biology 20030301
A novel chloride conductance activated by extracellular ATP in mouse parotid acinar cells. The Journal of physiology 20030215
Enhancement of aquaporin-3 by vasoactive intestinal polypeptide in a human colonic epithelial cell line. Journal of gastroenterology and hepatology 20030201
Pharmacological suppression of rat distal colon chloride secretion requires two blockers. Acta gastroenterologica Latinoamericana 20030101
1H-Nuclear magnetic resonance pattern recognition studies with N-phenylanthranilic acid in the rat: time- and dose-related metabolic effects. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101
Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells. Pflugers Archiv : European journal of physiology 20021201
Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes. European journal of pharmacology 20021011
Differential effect of epidermal growth factor on serous and mucous cells in porcine airway submucosal gland. Respiratory physiology & neurobiology 20020904
Effects of ion transport inhibitors on MCh-mediated secretion from porcine airway submucosal glands. Journal of applied physiology (Bethesda, Md. : 1985) 20020901
Effect of anion transport blockers on CFTR in the human sweat duct. The Journal of membrane biology 20020901
An outwardly rectifying anion channel in human leukaemic K562 cells. Pflugers Archiv : European journal of physiology 20020901
NaCl and fluid secretion by the intestine of the teleost Fundulus heteroclitus: involvement of CFTR. The Journal of experimental biology 20020301
Trafficking of GFP-tagged DeltaF508-CFTR to the plasma membrane in a polarized epithelial cell line. American journal of physiology. Cell physiology 20011201
Selective inhibition of Cl(-) conductance in toad skin by blockers of Cl(-) channels and transporters. American journal of physiology. Cell physiology 20011001
Mechanism of substance P-induced liquid secretion across bronchial epithelium. American journal of physiology. Lung cellular and molecular physiology 20010901
Fenamates: a novel class of reversible gap junction blockers. The Journal of pharmacology and experimental therapeutics 20010901
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 20010801
cAMP-dependent fluid secretion in rat inner medullary collecting ducts. American journal of physiology. Renal physiology 20010601
Diphenylamine-2-carboxylic acid (DPC), Usually an inhibitor of Cl- and non-selective cation channels, inhibits Cl-/HCO3- exchange and opens Cl- and cation conductances in rabbit gallbladder epithelium. Pflugers Archiv : European journal of physiology 20010601
Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia. American journal of physiology. Cell physiology 20010501
Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity. The Journal of biological chemistry 20010413
Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 20010401
Na+ reabsorption in cultured rat epididymal epithelium via the Na+/nucleoside cotransporter. Biology of reproduction 20010301
Malate-permeable channels and cation channels activated by aluminum in the apical cells of wheat roots. Plant physiology 20010301
Chloride channel function is linked to epithelium-dependent airway relaxation. American journal of physiology. Lung cellular and molecular physiology 20010201
Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells. The Journal of experimental biology 20010201
Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology (Baltimore, Md.) 20010101
Increased urinary uronic acid excretion in experimentally-induced renal papillary necrosis in rats. Renal failure 20010101
The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101
External Cl(-)-dependent formation of watery vacuoles by long-term hypotonic shock in 3T3-L1 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101
Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death. The Journal of biological chemistry 20000707
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. The Journal of general physiology 19930701
Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity. Journal of medicinal chemistry 19930430
The antisecretory effects of somatostatin and analogues in rat descending colon mucosa. European journal of pharmacology 19900810
Properties