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NS309

CAS No.:
18711-16-5
Catalog Number:
AG00AQC3
Molecular Formula:
C8H4Cl2N2O2
Molecular Weight:
231.0356
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$111
- +
10mg
≥98%
1 week
United States
$133
- +
50mg
≥98%
1 week
United States
$382
- +
Product Description
Catalog Number:
AG00AQC3
Chemical Name:
NS309
CAS Number:
18711-16-5
Molecular Formula:
C8H4Cl2N2O2
Molecular Weight:
231.0356
MDL Number:
MFCD06798346
IUPAC Name:
6,7-dichloro-3-nitroso-1H-indol-2-ol
InChI:
InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,11,13H
InChI Key:
ROBYKNONIPZMTK-UHFFFAOYSA-N
SMILES:
ON=C1C(=O)Nc2c1ccc(c2Cl)Cl
Properties
Complexity:
241  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
229.965g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
231.032g/mol
Monoisotopic Mass:
229.965g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
65.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
Small conductance calcium-activated potassium channels: from structure to function. Progress in neurobiology 20100701
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. British journal of pharmacology 20070701
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. The Journal of biological chemistry 20051216
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochimica et biophysica acta 20041011
Properties