SHU-9119
| Title | Journal |
|---|---|
| Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor. | Bioorganic & medicinal chemistry 20141115 |
| The effect of melanocortin (Mc3 and Mc4) antagonists on serotonin-induced food and water intake of broiler cockerels. | Journal of veterinary science 20120901 |
| Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20120301 |
| The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. | Physiology & behavior 20120201 |
| Neuronostatin induces hyperalgesia in formalin test in mice. | Neuroscience letters 20120106 |
| Central administration of neuronostatin induces antinociception in mice. | Peptides 20110901 |
| Intracerebroventricular administration of neuronostatin induces depression-like effect in forced swim test of mice. | Peptides 20110901 |
| Inflammation-induced lethargy is mediated by suppression of orexin neuron activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
| The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide. | Neuroscience research 20110501 |
| Melanocortin activity in the amygdala influences alcohol intake. | Pharmacology, biochemistry, and behavior 20110301 |
| Thyroid transcription factor-1 regulates feeding behavior via melanocortin pathway in the hypothalamus. | Diabetes 20110301 |
| Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats. | Regulatory peptides 20110117 |
| Visfatin induces sickness responses in the brain. | PloS one 20110101 |
| Solution structures and molecular interactions of selective melanocortin receptor antagonists. | Molecules and cells 20101201 |
| The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat. | Endocrinology 20100901 |
| Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100901 |
| Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity. | Journal of hypertension 20100701 |
| A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity. | Bioorganic & medicinal chemistry 20100301 |
| Role of central leptin signaling in renal macrophage infiltration. | Endocrine journal 20100101 |
| Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. | Diabetes 20091201 |
| A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin. | Diabetes 20090801 |
| Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701 |
| Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. | Endocrinology 20090401 |
| Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101 |
| Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway. | Diabetes 20090101 |
| Gestational weight gain by reduced brain melanocortin activity affects offspring energy balance in rats. | International journal of obesity (2005) 20090101 |
| Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study. | Pharmacological reports : PR 20090101 |
| Mechanisms mediating renal sympathetic activation to leptin in obesity. | American journal of physiology. Regulatory, integrative and comparative physiology 20081201 |
| Brain apolipoprotein E: an important regulator of food intake in rats. | Diabetes 20080801 |
| Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080521 |
| Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20080401 |
| A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally. | Peptides 20080101 |
| The central melanocortin system directly controls peripheral lipid metabolism. | The Journal of clinical investigation 20071101 |
| Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system. | Peptides 20070301 |
| Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. | The Journal of physiology 20070115 |
| Functional characterization of the modified melanocortin peptides responsible for ligand selectivity at the human melanocortin receptors. | Peptides 20061101 |
| Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. | Chemical biology & drug design 20061001 |
| Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat. | Brain research 20060802 |
| Activation of the melanocortin-4 receptor mobilizes intracellular free calcium in immortalized hypothalamic neurons. | The Journal of surgical research 20060515 |
| Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine. | Brain research 20060504 |
| Melanocortin modulation of inflammatory cytokine and neuroendocrine responses to endotoxin in the monkey. | Endocrinology 20060401 |
| Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction. | Biochemistry 20060131 |
| Effect of the melanocortin receptor stimulation or inhibition on ethanol intake in alcohol-preferring rats. | Peptides 20060101 |
| Feeding, body weight, and sensitivity to non-ingestive reward stimuli during and after 12-day continuous central infusions of melanocortin receptor ligands. | Peptides 20051101 |
| Inhibition of morphine tolerance by spinal melanocortin receptor blockade. | Pain 20051001 |
| Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats. | Neuroscience letters 20050805 |
| Effects of high-fat diets with different carbohydrate-to-protein ratios on energy homeostasis in rats with impaired brain melanocortin receptor activity. | American journal of physiology. Regulatory, integrative and comparative physiology 20050701 |
| Adrenocorticotropin evokes transient elevations in intracellular free calcium ([Ca2+]i) and increases basal [Ca2+]i in resting chondrocytes through a phospholipase C-dependent mechanism. | Endocrinology 20050701 |
| Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states. | The Journal of pharmacology and experimental therapeutics 20050601 |
| Blockade of melanocortin transmission inhibits cocaine reward. | The European journal of neuroscience 20050401 |
| alpha-MSH and gamma-MSH inhibit IL-1beta induced activation of the hypothalamic-pituitary-adrenal axis through central melanocortin receptors. | Regulatory peptides 20041115 |
| Activation of MAP kinase by MC4-R through PI3 kinase. | Regulatory peptides 20040815 |
| Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control. | Endocrinology 20040201 |
| Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats. | Brain research 20031121 |
| The effect of morphine on MC4 and CRF receptor mRNAs in the rat amygdala and attenuation of tolerance after their blockade. | Brain research 20031114 |
| Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. | The journal of peptide research : official journal of the American Peptide Society 20031101 |
| Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors. | European journal of pharmacology 20030923 |
| Interaction between the spinal melanocortin and opioid systems in a rat model of neuropathic pain. | Anesthesiology 20030801 |
| Alpha-melanocyte-stimulating hormone stimulates prolactin secretion through melanocortin-3 receptors expressed in mammotropes in the mouse pituitary. | Neuroendocrinology 20030801 |
| Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030601 |
| Inverse agonist activity of agouti and agouti-related protein. | Peptides 20030401 |
| Modulation of melanocortin-induced changes in spinal nociception by mu-opioid receptor agonist and antagonist in neuropathic rats. | Neuroreport 20021220 |
| Estradiol treatment fails to affect the feeding responses to melanocortin-3/4 receptor agonism or antagonism in ovariectomized rats. | Peptides 20020901 |
| Activation of central melanocortin pathways by fenfluramine. | Science (New York, N.Y.) 20020726 |
| Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity. | The Journal of biological chemistry 20020607 |
| Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. | American journal of physiology. Endocrinology and metabolism 20020401 |
| The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats. | Psychopharmacology 20020401 |
| Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain. | Anesthesia and analgesia 20011201 |
| Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO. | British journal of pharmacology 20011201 |
| Central melanocortin receptors regulate insulin action. | The Journal of clinical investigation 20011001 |
| Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. | Biochemistry 20010522 |
| Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515 |
| Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. | European journal of pharmacology 19990813 |
| Further pharmacological characterization of the selective melanocortin 4 receptor antagonist HS014: comparison with SHU9119. | Neuropeptides 19990601 |