Home Other Building Blocks (D-ALA7)-ANGIOTENSIN I/II (1-7)

(D-ALA7)-ANGIOTENSIN I/II (1-7)

CAS No.:
159432-28-7
Catalog Number:
AG00AP9F
Molecular Formula:
C39H60N12O11
Molecular Weight:
872.9675
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$140
- +
5mg
99%
1 week
United States
$173
- +
Product Description
Catalog Number:
AG00AP9F
Chemical Name:
(D-ALA7)-ANGIOTENSIN I/II (1-7)
CAS Number:
159432-28-7
Molecular Formula:
C39H60N12O11
Molecular Weight:
872.9675
MDL Number:
MFCD00672447
IUPAC Name:
(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(1R)-1-carboxyethyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
InChI:
InChI=1S/C39H60N12O11/c1-6-20(4)31(37(60)49-28(15-23-17-43-18-45-23)34(57)46-21(5)38(61)62)51-35(58)27(14-22-9-11-24(52)12-10-22)48-36(59)30(19(2)3)50-33(56)26(8-7-13-44-39(41)42)47-32(55)25(40)16-29(53)54/h9-12,17-21,25-28,30-31,52H,6-8,13-16,40H2,1-5H3,(H,43,45)(H,46,57)(H,47,55)(H,48,59)(H,49,60)(H,50,56)(H,51,58)(H,53,54)(H,61,62)(H4,41,42,44)/t20-,21+,25-,26-,27-,28-,30-,31-/m0/s1
InChI Key:
GZSZZUXDAPDPOR-NGIFJXEWSA-N
SMILES:
CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)O)C)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCNC(=N)N)Cc1ccc(cc1)O)C
Properties
Complexity:
1570  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
872.45g/mol
Formal Charge:
0
Heavy Atom Count:
62  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
13  
Isotope Atom Count:
0
Molecular Weight:
872.982g/mol
Monoisotopic Mass:
872.45g/mol
Rotatable Bond Count:
26  
Topological Polar Surface Area:
389A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.3  
Literature
Title Journal
Neuroprotective effect of angiotensin-(1-7) against rotenone-induced oxidative damage in CATH.a neurons. Toxicology in vitro : an international journal published in association with BIBRA 20180801
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. Blood 20150122
ANG-(1-7) reduces ANG II-induced insulin resistance by enhancing Akt phosphorylation via a Mas receptor-dependent mechanism in rat skeletal muscle. Biochemical and biophysical research communications 20120928
Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes. Pharmacological research 20120901
Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regulatory peptides 20120820
The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7). Regulatory peptides 20120820
Angiotensin-(1-7) suppresses the number and function of the circulating fibrocytes by upregulating endothelial nitric oxide synthase expression. Molecular and cellular biochemistry 20120601
Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Experimental physiology 20120501
Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells. American journal of physiology. Renal physiology 20120315
Angiotensin-(1-7) attenuates the chronotropic response to angiotensin II via stimulation of PTEN in the spontaneously hypertensive rat neurons. American journal of physiology. Heart and circulatory physiology 20120301
Angiotensin-(1-7) induces peripheral antinociception through mas receptor activation in an opioid-independent pathway. Pharmacology 20120101
Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure. Hypertension (Dallas, Tex. : 1979) 20111201
Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Experimental physiology 20111001
Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure. Hypertension (Dallas, Tex. : 1979) 20111001
Angiotensin-(1-7) induces ovulation and steroidogenesis in perfused rabbit ovaries. Experimental physiology 20110901
Chronic treatment with angiotensin-(1-7) improves renal endothelial dysfunction in apolipoproteinE-deficient mice. British journal of pharmacology 20110701
Beneficial effects of angiotensin (1-7) in diabetic rats with cardiomyopathy. Therapeutic advances in cardiovascular disease 20110601
Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester. Journal of cardiovascular pharmacology 20110501
Endogenous angiotensin II suppresses stretch-induced ANP secretion via AT1 receptor pathway. Peptides 20110201
Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. Brain research 20110112
Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism. American journal of physiology. Cell physiology 20110101
Role of angiotensin-(1-7) in rostral ventrolateral medulla in blood pressure regulation via sympathetic nerve activity in Wistar-Kyoto and spontaneous hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101
Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. Toxicology letters 20101130
The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells. Hypertension research : official journal of the Japanese Society of Hypertension 20101101
Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla. Cardiovascular research 20100801
Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 20100801
Improved lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7). Arteriosclerosis, thrombosis, and vascular biology 20100501
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro. Journal of hypertension 20100501
Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas. Regulatory peptides 20100409
Angiotensin-(1-7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats. Pflugers Archiv : European journal of physiology 20100401
Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clinical and experimental pharmacology & physiology 20100101
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension (Dallas, Tex. : 1979) 20100101
Ameliorative potential of angiotensin1-7/Mas receptor axis in streptozotocin-induced diabetic nephropathy in rats. Methods and findings in experimental and clinical pharmacology 20100101
Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration. PloS one 20100101
Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides 20091001
Acute modulation of myocardial function by angiotensin 1-7. Peptides 20090901
Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats. Pharmacological research 20090401
Endothelium-dependent relaxation factor released by perivascular adipose tissue. Journal of hypertension 20090401
Angiotensin II-mediated vasodilation is reduced in adult spontaneously hypertensive rats despite enhanced expression of AT2 receptors. Clinical and experimental pharmacology & physiology 20090101
Regulation of ACE2 in cardiac myocytes and fibroblasts. American journal of physiology. Heart and circulatory physiology 20081201
MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. American journal of physiology. Cell physiology 20081101
Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye. Investigative ophthalmology & visual science 20080601
Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. Journal of cardiovascular pharmacology 20080601
Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension (Dallas, Tex. : 1979) 20071201
Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function. Journal of hypertension 20071201
Angiotensin II increases evoked release at the frog neuromuscular junction through a receptor sensitive to A779. Brain research 20071017
Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. American journal of physiology. Heart and circulatory physiology 20071001
Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats. Hypertension (Dallas, Tex. : 1979) 20071001
Angiotensin-(1-7) inhibits in vitro endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor. Endocrine 20071001
Different responses to angiotensin-(1-7) in young, aged and diabetic rabbit corpus cavernosum. Pharmacological research 20070901
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors. American journal of physiology. Heart and circulatory physiology 20070801
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production. Pharmacological research 20070701
Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla. Regulatory peptides 20070607
On the mechanism of coronary vasodilation induced by angiotensin-(1-7) in the isolated guinea pig heart. Basic & clinical pharmacology & toxicology 20070601
The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of Angiotensin-(1-7). Journal of hepatology 20070401
Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I. Canadian journal of physiology and pharmacology 20061101
Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid. Life sciences 20060501
Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension (Dallas, Tex. : 1979) 20051001
Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart. Hypertension (Dallas, Tex. : 1979) 20051001
Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors. Journal of the renin-angiotensin-aldosterone system : JRAAS 20050901
Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. Hypertension (Dallas, Tex. : 1979) 20050801
In vivo characterization of the angiotensin-(1-7)-induced dopamine and gamma-aminobutyric acid release in the striatum of the rat. The European journal of neuroscience 20050801
Pharmacological concentration of angiotensin-(1-7) activates NADPH oxidase after ischemia-reperfusion in rat heart through AT1 receptor stimulation. Regulatory peptides 20050415
Evidence for a functional cardiac interaction between losartan and angiotensin-(1-7) receptors revealed by orthostatic tilting test in rats. British journal of pharmacology 20050301
Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway. The Journal of pharmacology and experimental therapeutics 20041001
Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor. Regulatory peptides 20040815
Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. Regulatory peptides 20040415
Angiotensin-(1-7) stimulates water transport in rat inner medullary collecting duct: evidence for involvement of vasopressin V2 receptors. Pflugers Archiv : European journal of physiology 20031101
The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats. Journal of the renin-angiotensin-aldosterone system : JRAAS 20030901
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7). Hypertension (Dallas, Tex. : 1979) 20021101
Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension (Dallas, Tex. : 1979) 20020301
Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor. Regulatory peptides 20020115
1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive rats. Peptides 20020101
Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. Hypertension (Dallas, Tex. : 1979) 20010901
Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis. American journal of physiology. Regulatory, integrative and comparative physiology 20010401
Alterations of the renin-angiotensin system at the RVLM of transgenic rats with low brain angiotensinogen. American journal of physiology. Regulatory, integrative and comparative physiology 20010201
Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo. Hypertension (Dallas, Tex. : 1979) 20010201
Properties