Home Other Building Blocks 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID

CAS No.:
179528-45-1
Catalog Number:
AG00AP3F
Molecular Formula:
C9H7IO2S
Molecular Weight:
306.1201
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$151
- +
10mg
98%
1 week
United States
$240
- +
25mg
≥98%
1 week
United States
$435
- +
50mg
98%
1 week
United States
$740
- +
100mg
98%
1 week
United States
$1290
- +
Product Description
Catalog Number:
AG00AP3F
Chemical Name:
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
CAS Number:
179528-45-1
Molecular Formula:
C9H7IO2S
Molecular Weight:
306.1201
MDL Number:
MFCD00949076
IUPAC Name:
(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
InChI:
InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-
InChI Key:
DJCVSFWGKYHMKH-YVMONPNESA-N
SMILES:
SC(=Cc1ccc(cc1)I)C(=O)O
Properties
Complexity:
220  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
305.921g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
306.117g/mol
Monoisotopic Mass:
305.921g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
38.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9  
Literature
Title Journal
Neurotrophins and cholinergic enzyme regulated by calpain-2: New insights into neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology letters 20180701
Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology letters 20170805
Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. Toxicology and applied pharmacology 20161001
Role of calcium and calpain in the downregulation of voltage-gated sodium channel expression by the pyrethroid pesticide deltamethrin. Journal of biochemical and molecular toxicology 20150301
Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. American journal of physiology. Cell physiology 20130301
Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition. Experimental hematology 20120701
Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity. Biochemical and biophysical research communications 20120622
Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. Archives of biochemistry and biophysics 20111215
Nuclear translocation of calpain-2 regulates propensity toward apoptosis in cardiomyocytes of tail-suspended rats. Journal of cellular biochemistry 20110201
Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. Cell death & disease 20101101
Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration. Experimental eye research 20100901
Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells. The Journal of pharmacology and experimental therapeutics 20100801
Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis. Neuroscience letters 20100726
Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. Experimental cell research 20100215
Measuring calpain activity in fixed and living cells by flow cytometry. Journal of visualized experiments : JoVE 20100101
The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor. Experimental neurology 20090801
Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia. Cardiovascular research 20090701
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell death and differentiation 20081201
Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein. Tissue antigens 20080701
Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Experimental cell research 20080610
Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes. American journal of physiology. Cell physiology 20080301
Calpain inhibition but not reticulum endoplasmic stress preconditioning protects rat kidneys from p-aminophenol toxicity. Toxicological sciences : an official journal of the Society of Toxicology 20070901
Flow cytometric measurement of calpain activity in living cells. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070701
Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species. Biochemical pharmacology 20070630
Activation of LFA-1 by ionomycin is independent of calpain-mediated talin cleavage. Biochemical and biophysical research communications 20070427
Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Molecular pharmacology 20061101
Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells. Toxicological sciences : an official journal of the Society of Toxicology 20061101
Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. American journal of physiology. Renal physiology 20061001
Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells. Kidney international 20061001
Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. American journal of physiology. Renal physiology 20060901
Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells. Cancer research 20060801
Calcium-dependent release of NO from intracellular S-nitrosothiols. The EMBO journal 20060712
Group B Streptococcus induces macrophage apoptosis by calpain activation. Journal of immunology (Baltimore, Md. : 1950) 20060615
Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line. Experimental cell research 20060115
Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro. Reproduction (Cambridge, England) 20060101
Inhibition of cysteine protease activity disturbs DNA replication and prevents mitosis in the early mitotic cell cycles of sea urchin embryos. Journal of cellular physiology 20050801
Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorganic & medicinal chemistry letters 20050615
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury. Biochemical pharmacology 20050401
Ischemia-induced increase in long-term potentiation is warded off by specific calpain inhibitor PD150606. Brain research 20041022
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine. Antiviral chemistry & chemotherapy 20040101
Apoptosis induced by simvastatin in rat vascular smooth muscle cell through Ca2+-calpain and caspase-3 dependent pathway. Pharmacological research 20031201
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes. Molecular and cellular biochemistry 20030901
A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. Journal of molecular biology 20030418
Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury? Kidney international 20030301
Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death. The Journal of pharmacology and experimental therapeutics 20030101
An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition. Neuropharmacology 20020401
Calpains mediate acute renal cell death: role of autolysis and translocation. American journal of physiology. Renal physiology 20011001
Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. Journal of virology 19990101
Properties