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SAUCHINONE

CAS No.:
177931-17-8
Catalog Number:
AG00AP2Q
Molecular Formula:
C20H20O6
Molecular Weight:
356.3692
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
≥98%
1 week
United States
$179
- +
10mg
≥98%
1 week
United States
$283
- +
Product Description
Catalog Number:
AG00AP2Q
Chemical Name:
SAUCHINONE
CAS Number:
177931-17-8
Molecular Formula:
C20H20O6
Molecular Weight:
356.3692
MDL Number:
MFCD08702698
IUPAC Name:
(1S,12R,13S,14R,16R,23R)-13,14-dimethyl-2,6,8,20,22-pentaoxahexacyclo[10.10.1.01,19.03,11.05,9.016,23]tricosa-3,5(9),10,18-tetraen-17-one
InChI:
InChI=1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1
InChI Key:
GMTJIWUFFXGFHH-WPAOEJHSSA-N
SMILES:
C[C@@H]1C[C@H]2C(=O)C=C3[C@]4([C@@H]2[C@@H]([C@H]1C)c1cc2OCOc2cc1O4)OCO3
Properties
Complexity:
675  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
356.126g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
356.374g/mol
Monoisotopic Mass:
356.126g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
63.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells. Chemico-biological interactions 20170105
Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress. Toxicology and applied pharmacology 20160601
Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. Chemico-biological interactions 20141205
Quantitative determination of sauchinone in rat plasma by liquid chromatography-mass spectrometry. Biomedical chromatography : BMC 20121001
Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways. Journal of Korean medical science 20120501
Protective effect of sauchinone on methamphetamine-induced neurotoxicity in mice. Journal of pharmacological sciences 20120101
Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway. British journal of pharmacology 20110801
Sauchinone protects pancreatic β cells against cytokine-mediated toxicity. Toxicology in vitro : an international journal published in association with BIBRA 20110301
Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages. Biological & pharmaceutical bulletin 20110101
Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation. International immunopharmacology 20100901
Protective effect of sauchinone by upregulating heme oxygenase-1 via the P38 MAPK and Nrf2/ARE pathways in HepG2 cells. Planta medica 20100101
Sauchinone reduces oxygen-glucose deprivation-evoked neuronal cell death via suppression of intracellular radical production. Archives of pharmacal research 20091101
Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury. Free radical biology & medicine 20091001
Inhibition of osteoclast differentiation and bone resorption by sauchinone. Biochemical pharmacology 20070915
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB. Planta medica 20031201
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells. Biological & pharmaceutical bulletin 20031001
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. British journal of pharmacology 20030501
Properties