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Glatiramer acetate

CAS No.:
147245-92-9
Catalog Number:
AG00AOW0
Molecular Formula:
C25H45N5O13
Molecular Weight:
623.6505
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$97
- +
5mg
≥95%
1 week
United States
$208
- +
10mg
≥95%
1 week
United States
$319
- +
25mg
≥95%
1 week
United States
$510
- +
Product Description
Catalog Number:
AG00AOW0
Chemical Name:
Glatiramer acetate
CAS Number:
147245-92-9
Molecular Formula:
C25H45N5O13
Molecular Weight:
623.6505
MDL Number:
MFCD27978717
IUPAC Name:
acetic acid;(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2-aminopropanoic acid;(2S)-2,6-diaminohexanoic acid
InChI:
InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1
InChI Key:
FHEAIOHRHQGZPC-KIWGSFCNSA-N
SMILES:
C[C@@H](C(=O)O)N.Oc1ccc(cc1)C[C@@H](C(=O)O)N.OC(=O)CC[C@@H](C(=O)O)N.CC(=O)O.NCCCC[C@@H](C(=O)O)N
Properties
Complexity:
519  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
623.301g/mol
Formal Charge:
0
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
12  
Isotope Atom Count:
0
Molecular Weight:
623.657g/mol
Monoisotopic Mass:
623.301g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
374A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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The results of two multicenter, open-label studies assessing efficacy, tolerability and safety of protiramer, a high molecular weight synthetic copolymeric mixture, in patients with relapsing-remitting multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 20090201
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Short-term combination of glatiramer acetate with i.v. steroid treatment preceding treatment with GA alone assessed by MRI-disease activity in patients with relapsing-remitting multiple sclerosis. Journal of the neurological sciences 20080315
Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2. Journal of immunology (Baltimore, Md. : 1950) 20080315
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Concomitant radiochemotherapy in a patient with multiple sclerosis and glioblastoma. Clinical neuropathology 20080101
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An urticarial vasculitis case induced by glatiramer acetate. The Journal of dermatological treatment 20080101
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A longitudinal observational study of a cohort of patients with relapsing-remitting multiple sclerosis treated with glatiramer acetate. European journal of neurology 20071101
The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cells. Immunology letters 20071015
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Randomized, double-blind, dose-comparison study of glatiramer acetate in relapsing-remitting MS. Neurology 20070320
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Glatiramer acetate could be a potential antidepressant through its neuroprotective and anti-inflammatory effects. Medical hypotheses 20070101
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Immunomodulatory treatment of early onset multiple sclerosis: results of an Italian Co-operative Study. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20051201
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Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. The Journal of clinical investigation 20050901
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The distribution of the magnetic resonance imaging response to glatiramer acetate in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 20050801
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Putative mechanisms of action of statins in multiple sclerosis--comparison to interferon-beta and glatiramer acetate. Journal of the neurological sciences 20050615
Twenty-four-month comparison of immunomodulatory treatments - a retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (Copaxone). European journal of neurology 20050601
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A practical approach to immunomodulatory therapy for multiple sclerosis. Physical medicine and rehabilitation clinics of North America 20050501
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Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat. Investigative ophthalmology & visual science 20050301
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Cancer incidence in multiple sclerosis and effects of immunomodulatory treatments. Breast cancer research and treatment 20050201
Additive effect of the combination of glatiramer acetate and minocycline in a model of MS. Journal of neuroimmunology 20050101
Combined treatment of glatiramer acetate and low doses of immunosuppressive drugs is effective in the prevention of graft rejection. International immunopharmacology 20050101
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