N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)acrylamide
| Title | Journal |
|---|---|
| Polychlorinated biphenyl 104 promotes migration of endometrial stromal cells in endometriosis. | Toxicology letters 20180615 |
| Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration. | PloS one 20130101 |
| Irreversible protein kinase inhibitors: balancing the benefits and risks. | Journal of medicinal chemistry 20120726 |
| Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides. | Journal of medicinal chemistry 20120308 |
| The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells. | Neuro-oncology 20120301 |
| Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system. | Antioxidants & redox signaling 20120215 |
| A re-assessment of the effects of treatment with an epidermal growth factor receptor (EGFR) inhibitor on recovery of bladder and locomotor function following thoracic spinal cord injury in rats. | Experimental neurology 20120201 |
| Phenylbutyrate suppresses distinct skin reactions that are enhanced by blockade of epidermal growth factor receptor signaling. | Journal of dermatological science 20111201 |
| Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes. | Clinical cancer research : an official journal of the American Association for Cancer Research 20110701 |
| Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation. | The Journal of investigative dermatology 20110201 |
| Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. | Science (New York, N.Y.) 20100924 |
| Ultraviolet B radiation of human skin generates platelet-activating factor receptor agonists. | Photochemistry and photobiology 20100701 |
| Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor. | Journal of medicinal chemistry 20100408 |
| Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion. | Journal of medicinal chemistry 20100311 |
| Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation. | Cancer research 20100201 |
| Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth. | Brain : a journal of neurology 20091101 |
| Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia. | Neurobiology of disease 20091001 |
| Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. | American journal of physiology. Cell physiology 20090401 |
| Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway. | Journal of biomedical science 20090101 |
| A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215 |
| Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase. | Bioorganic & medicinal chemistry letters 20081115 |
| MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. | Bioorganic & medicinal chemistry 20080401 |
| Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080201 |
| Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility. | Asian journal of andrology 20070901 |
| Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070613 |
| Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. | Nature chemical biology 20070401 |
| EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells. | Journal of the American Society of Nephrology : JASN 20070101 |
| Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects. | Journal of medicinal chemistry 20061116 |
| Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. | American journal of physiology. Renal physiology 20060801 |
| Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells. | Molecular cancer research : MCR 20060601 |
| Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells. | Biochemical pharmacology 20060314 |
| Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2). | Journal of medicinal chemistry 20030102 |
| 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity. | Journal of medicinal chemistry 20010816 |
| Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor. | Journal of medicinal chemistry 20010201 |
| Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. | Journal of medicinal chemistry 20000406 |