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Almotriptan

CAS No.:
154323-57-6
Catalog Number:
AG00AOFB
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00AOFB
Chemical Name:
Almotriptan
CAS Number:
154323-57-6
MDL Number:
MFCD00927104
IUPAC Name:
N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine
InChI:
InChI=1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3
InChI Key:
WKEMJKQOLOHJLZ-UHFFFAOYSA-N
UNII:
1O4XL5SN61
NSC Number:
760092
Properties
Complexity:
483  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
335.167g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
335.466g/mol
Monoisotopic Mass:
335.167g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
64.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6  
Literature
Title Journal
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Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study. The journal of headache and pain 20120701
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Oral sumatriptan and almotriptan--delimiting the MAOI effect. Headache 20120501
Italian guidelines for primary headaches: 2012 revised version. The journal of headache and pain 20120501
Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120501
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Migraine in women: the role of hormones and their impact on vascular diseases. The journal of headache and pain 20120401
LC-ESI-MS/MS determination of in vivo metabolites of almotriptan in rat plasma, urine and feces: application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120401
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Two chromatographic methods for the determination of some antimigraine drugs. Analytical chemistry insights 20120101
Method development and validation of almotriptan in human plasma by HPLC tandem mass spectrometry: application to pharmacokinetic study. Scientia pharmaceutica 20120101
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A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine. The journal of headache and pain 20110601
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Why pharmacokinetic differences among oral triptans have little clinical importance: a comment. The journal of headache and pain 20110201
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Overview of diagnosis and management of paediatric headache. Part II: therapeutic management. The journal of headache and pain 20110201
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
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Influence of trigger factors on the efficacy of almotriptan as early intervention for the treatment of acute migraine in a primary care setting: the START study. Expert review of neurotherapeutics 20100901
Triptans for the management of migraine. Drugs 20100820
Early responses in randomized clinical trials of triptans in acute migraine treatment. Are they clinically relevant? A comment. Headache 20100701
Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601
Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: the START study. International journal of clinical practice 20100601
Long-term, open-label safety study of oral almotriptan 12.5 mg for the acute treatment of migraine in adolescents. Headache 20100501
Drug dependence associated with triptans and ergot derivatives: a case/non-case study. European journal of clinical pharmacology 20100401
Acute management of migraine. The Journal of the Association of Physicians of India 20100401
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Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. Annals of the rheumatic diseases 20100201
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Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form. Indian journal of pharmaceutical sciences 20100101
[Acute migraine: a treatment reserved for adults now recommended for adolescents]. Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20100101
Early treatment of acute migraine: new evidence of benefits. Cephalalgia : an international journal of headache 20091201
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Variation in almotriptan effectiveness according to different prophylactic treatments. Headache 20091001
5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials. Journal of clinical medicine research 20090601
Migraine treatment with rizatriptan and almotriptan: a crossover study. Headache 20090501
[Almotriptan vs. ergotamine plus caffeine for acute migraine treatment. A cost-efficacy analysis]. Neurologia (Barcelona, Spain) 20090401
Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention. Headache 20090301
Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia? Headache 20090301
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Seizure after use of almotriptan. Clinical neurology and neurosurgery 20080901
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A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate API. Journal of pharmaceutical and biomedical analysis 20080313
Migraine-like headache in intracranial haemorrhage is alleviated by sumatriptan and almotriptan. Cephalalgia : an international journal of headache 20080301
Effect of early intervention with almotriptan vs placebo on migraine-associated functional disability: results from the AEGIS Trial. Headache 20080301
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Disposition and metabolism of almotriptan in rats, dogs and monkeys. Xenobiotica; the fate of foreign compounds in biological systems 20060901
Ethanol does not significantly affect the bioavailability of almotriptan: an open, randomized, crossover, single-dose, phase I clinical trial in healthy volunteers. International journal of clinical pharmacology and therapeutics 20060901
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Patterns of use of triptans and reasons for switching them in a tertiary care migraine population. Headache 20040101
A comparison of the cost-effectiveness of almotriptan and sumatriptan in the treatment of acute migraine using a composite efficacy/tolerability end point. Journal of managed care pharmacy : JMCP 20040101
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A review of the clinical efficacy and tolerability of almotriptan in acute migraine. Expert opinion on pharmacotherapy 20030701
Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug metabolism and disposition: the biological fate of chemicals 20030401
Interaction between ketoconazole and almotriptan in healthy volunteers. Journal of clinical pharmacology 20030401
A case of carotidynia with response to almotriptan. Cephalalgia : an international journal of headache 20030301
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Almotriptan versus rizatriptan in patients with migraine in Spain. Headache 20030101
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Meta-analysis of oral triptan therapy for migraine: number needed to treat and relative cost to achieve relief within 2 hours. Journal of managed care pharmacy : JMCP 20030101
Early intervention with almotriptan improves sustained pain-free response in acute migraine. Headache 20030101
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Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers. Journal of clinical pharmacology 20021201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021201
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Triptan medications to treat acute migraine. Lancet (London, England) 20020330
Triptan medications to treat acute migraine. Lancet (London, England) 20020330
Triptan medications to treat acute migraine. Lancet (London, England) 20020330
Cardiovascular effect of almotriptan in treated hypertensive patients. Clinical pharmacology and therapeutics 20020301
Almotriptan (Axert) and frovatriptan (Frova) for migrane. The Medical letter on drugs and therapeutics 20020218
Cost savings in migraine associated with less chest pain on new triptan therapy. The American journal of managed care 20020201
Migraine: diagnosis, management, and new treatment options. The American journal of managed care 20020201
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Economic comparison of oral triptans for management of acute migraine: implications for managed care. The American journal of managed care 20020201
Health outcomes evaluations: estimating the impact of almotriptan in managed care settings. The American journal of managed care 20020201
Almotriptan versus sumatriptan in migraine treatment: direct medical costs of managing adverse chest symptoms. The American journal of managed care 20020201
[Profile of the antimigraine drug almotriptan]. Neurologia (Barcelona, Spain) 20020201
How does almotriptan compare with other triptans? A review of data from placebo-controlled clinical trials. Headache 20020201
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Clinical benefits of early triptan therapy for migraine. Headache 20020101
Tripstar: a comprehensive patient-based approach to compare triptans. Headache 20020101
Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis. Headache 20020101
Almotriptan increases pain-free status in patients with acute migraine treated in placebo-controlled clinical trials. Headache 20020101
Impact of chest pain on cost of migraine treatment with almotriptan and sumatriptan. Headache 20020101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20020101
Almotriptan increases sustained pain-free outcomes in acute migraine: results from three controlled clinical trials. Headache 20020101
Within-patient early versus delayed treatment of migraine attacks with almotriptan: the sooner the better. Headache 20020101
A long-term open-label study of oral almotriptan 12.5 mg for the treatment of acute migraine. Headache 20020101
Spotlight on almotriptan in migraine. CNS drugs 20020101
Rizatriptan: an update of its use in the management of migraine. Drugs 20020101
Spotlight on rizatriptan in migraine. CNS drugs 20020101
Almotriptan, a new anti-migraine agent: a review. CNS drug reviews 20020101
Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine. Neurology 20011127
Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet (London, England) 20011117
Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study. Clinical therapeutics 20011101
Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries. Cephalalgia : an international journal of headache 20011001
Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittel-Forschung 20010901
Almotriptan: a novel 5-HT1B/D agonist for the symptomatic treatment of migraine. Expert review of neurotherapeutics 20010901
Almotriptan joins migraine market. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010801
[Migraine headache. Severe attacks: triptans are essential]. MMW Fortschritte der Medizin 20010719
Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans). Archives of neurology 20010701
Oral almotriptan vs. oral sumatriptan in the abortive treatment of migraine: a double-blind, randomized, parallel-group, optimum-dose comparison. Archives of neurology 20010601
Oral almotriptan in the treatment of migraine: safety and tolerability. Headache 20010501
Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans. British journal of clinical pharmacology 20010501
[Current topics: expectation for new triptans]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410
Hemodynamic and electrocardiographic effects of almotriptan in healthy volunteers. Journal of cardiovascular pharmacology 20010301
Acute treatment of migraine and the role of triptans. Current neurology and neuroscience reports 20010301
Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers. Journal of clinical pharmacology 20010201
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Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers. Cephalalgia : an international journal of headache 20010201
Long-term efficacy and safety of oral almotriptan: interim analysis of a 1-year open study. Headache 20010101
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