Home Halogens 6,7-Dichloroindoline-2,3-dione

6,7-Dichloroindoline-2,3-dione

CAS No.:
18711-12-1
Catalog Number:
AG00ANEJ
Molecular Formula:
C8H3Cl2NO2
Molecular Weight:
216.0209
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
95%
In Stock USA
United States
$226
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Product Description
Catalog Number:
AG00ANEJ
Chemical Name:
6,7-Dichloroindoline-2,3-dione
CAS Number:
18711-12-1
Molecular Formula:
C8H3Cl2NO2
Molecular Weight:
216.0209
MDL Number:
MFCD03618551
IUPAC Name:
6,7-dichloro-1H-indole-2,3-dione
InChI:
InChI=1S/C8H3Cl2NO2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12/h1-2H,(H,11,12,13)
InChI Key:
XTXIILHWOQZVAQ-UHFFFAOYSA-N
SMILES:
O=C1C(=O)Nc2c1ccc(c2Cl)Cl
Properties
Complexity:
269  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
214.954g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
216.017g/mol
Monoisotopic Mass:
214.954g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
46.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2  
Literature
Title Journal
Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives. British journal of pharmacology 20120501
Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat. The Journal of pharmacology and experimental therapeutics 20111201
IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell calcium 20111101
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell death & disease 20110401
Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain research 20100812
Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British journal of pharmacology 20100701
Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries. The Journal of pharmacology and experimental therapeutics 20100401
Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteries. American journal of physiology. Lung cellular and molecular physiology 20100401
Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans. Hypertension (Dallas, Tex. : 1979) 20100301
NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British journal of pharmacology 20100101
Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles. Investigative ophthalmology & visual science 20090801
Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401
TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels. Journal of neurochemistry 20081101
Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons. Anesthesia and analgesia 20080901
Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. Surgery 20080801
Openers of calcium-activated potassium channels and endothelium-dependent hyperpolarizations in the guinea pig carotid artery. Naunyn-Schmiedeberg's archives of pharmacology 20080401
Fluorescence-based Tl(+)-influx assays as a novel approach for characterization of small-conductance Ca(2+)-activated K (+) channel modulators. Methods in molecular biology (Clifton, N.J.) 20080101
Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains. British journal of pharmacology 20070601
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. Journal of medicinal chemistry 20070419
Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Molecular pharmacology 20061101
Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats. The Journal of urology 20060901
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochimica et biophysica acta 20041011
Properties