Facile synthesis of dispirooxindole-fused heterocycles via domino 1,4-dipolar addition and Diels-Alder reaction of in situ generated Huisgen 1,4-dipoles.

Organic letters 20121019

Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.

Journal of medicinal chemistry 20120927

Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.

Organic letters 20120921

Application of the systems chemistry approach on the ammonolysis of 1-ethoxycarbonyl- and 1-phenoxycarbonyl-3-(2-thienyl)oxindoles. A method to predict reactivity.

The Journal of organic chemistry 20120907

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease.

Bioorganic & medicinal chemistry letters 20120901

Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles.

Organic & biomolecular chemistry 20120821

Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins.

Organic letters 20120803

Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus.

Journal of enzyme inhibition and medicinal chemistry 20120801

Enamino-oxindole HIV protease inhibitors.

Bioorganic & medicinal chemistry letters 20120801

Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)/cyclization cascade sequence as the key step.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120727

Strategies for the enantioselective synthesis of spirooxindoles.

Organic & biomolecular chemistry 20120721

Enantioselective synthesis of 3,3'-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction.

Organic & biomolecular chemistry 20120721

Organocatalytic enantioselective stereoablative hydroxylation of 3-halooxindoles: an effective method for the construction of enantioenriched 3-substituted 3-hydroxy-2-oxindoles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120716

Catalytic asymmetric synthesis of spirooxindoles by a mannich-type reaction of isothiocyanato oxindoles.

Angewandte Chemie (International ed. in English) 20120709

Diastereodivergent synthesis of 3-spirocyclopropyl-2-oxindoles through direct enantioselective cyclopropanation of oxindoles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120702

Catalytic asymmetric exo'-selective [3+2] cycloaddition for constructing stereochemically diversified spiro[pyrrolidin-3,3'-oxindole]s.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120702

Enantioselective Michael addition of 3-aryl-substituted oxindoles to methyl vinyl ketone catalyzed by a binaphthyl-modified bifunctional organocatalyst.

Molecules (Basel, Switzerland) 20120618

Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles.

Organic letters 20120601

Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides.

Chemical communications (Cambridge, England) 20120525

Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120521

Phenyliodine bis(trifluoroacetate)-mediated oxidative C-C bond formation: synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides.

Organic letters 20120504

Access to spirocyclic oxindoles via N-heterocyclic carbene-catalyzed reactions of enals and oxindole-derived α,β-unsaturated imines.

Organic letters 20120504

A novel class of sugar-based ether-linked-dispirooxindolo-pyrrolidines/pyrrolizidines through [3+2]-cycloaddition of azomethine ylides.

Carbohydrate research 20120501

Intramolecular 1,3-dipolar cycloaddition reactions in the synthesis of complex annelated quinolines, α-carbolines and coumarins.

Molecular diversity 20120501

Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity.

European journal of medicinal chemistry 20120501

A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles.

Organic & biomolecular chemistry 20120428

Ionic nucleophilic catalysis of chiral ammonium betaines for highly stereoselective aldol reaction from oxindole-derived vinylic carbonates.

Journal of the American Chemical Society 20120425

Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.

ACS combinatorial science 20120409

Zinc-mediated diastereoselective synthesis of 3-amino oxindoles by addition of methyl and terminal alkynes to N-tert-butanesulfinyl ketimines.

The Journal of organic chemistry 20120406

Ring enlargement versus selenoetherification on the reaction of allenyl oxindoles with selenenylating reagents.

The Journal of organic chemistry 20120406

Aza-oxindole synthesis by oxidative coupling of C(sp2)-H and C(sp3)-H centers.

Chemical communications (Cambridge, England) 20120325

Palladium-catalyzed amidation by chemoselective C(sp3)-H activation: concise route to oxindoles using a carbamoyl chloride precursor.

Angewandte Chemie (International ed. in English) 20120312

Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy-Marbet Claisen rearrangement.

Angewandte Chemie (International ed. in English) 20120305

N-Heterocyclic carbene-catalyzed three-component domino reaction of alkynyl aldehydes with oxindoles.

Organic letters 20120302

Efficient synthesis of multicyclic spirooxindoles via a cascade Michael/Michael/oxa-Michael reaction of curcumins and isatylidene malononitriles.

Organic & biomolecular chemistry 20120227

Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.

Chemical communications (Cambridge, England) 20120227

Development of a nano-electrospray MSn method for the analysis of serotonin and related compounds in urine using a LTQ-orbitrap mass spectrometer.

Talanta 20120215

Facile synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via Brønsted acid catalyzed sp3 C-H functionalization.

Organic letters 20120203

The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis.

The Plant journal : for cell and molecular biology 20120201

Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.

Molecular diversity 20120201

Building addressable libraries: amino acid derived fluorescent linkers.

Langmuir : the ACS journal of surfaces and colloids 20120124

Core-structure-oriented asymmetric organocatalytic substitution of 3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine.

Angewandte Chemie (International ed. in English) 20120123

Dioxindole in asymmetric catalytic synthesis: routes to enantioenriched 3-substituted 3-hydroxyoxindoles and the preparation of maremycin A.

Angewandte Chemie (International ed. in English) 20120123

Synthesis of oxindoles via visible light photoredox catalysis.

Organic & biomolecular chemistry 20120121

Highly efficient and stereoselective construction of dispiro-[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles.

Organic letters 20120120

Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary amine thiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters.

Organic & biomolecular chemistry 20120114

Enantioselective organocatalytic oxyamination of unprotected 3-substituted oxindoles.

Organic & biomolecular chemistry 20120114

Synthesis of highly functionalized chiral 3,3'-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates.

Organic letters 20120106

HPLC analysis of oxindole alkaloids in Uncaria tomentosa: sample preparation and analysis optimisation by factorial design.

Phytochemical analysis : PCA 20120101

Comparative study of fourteen alkaloids from Uncaria rhynchophylla hooks and leaves using HPLC-diode array detection-atmospheric pressure chemical ionization/MS method.

Chemical & pharmaceutical bulletin 20120101

Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature.

World journal of surgical oncology 20120101

Synthesis of a dual functional anti-MDR tumor agent PH II-7 with elucidations of anti-tumor effects and mechanisms.

PloS one 20120101

Ethylene in organic synthesis: a new route to anticholenergic pyrrolidinoindolines, and other molecules with all carbon-quaternary centers via asymmetric hydrovinylation.

Organic letters 20111216

Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence.

Organic letters 20111202

Highly enantioselective one-pot synthesis of spirocyclopentaneoxindoles containing the oxime group by organocatalyzed Michael addition/ISOC/fragmentation sequence.

Organic letters 20111202

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.

European journal of medicinal chemistry 20111201

Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand.

Journal of inorganic biochemistry 20111201

Pericyclic cascade with chirality transfer: reaction pathway and origin of enantioselectivity of the hetero-Claisen approach to oxindoles.

Angewandte Chemie (International ed. in English) 20111125

Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B).

Journal of the American Chemical Society 20111116

Polarized IR spectra of the hydrogen bond in two different oxindole polymorphs with cyclic dimers in their lattices.

The journal of physical chemistry. A 20111110

Development of an LC-MS/MS method for the analysis of serotonin and related compounds in urine and the identification of a potential biomarker for attention deficit hyperactivity/hyperkinetic disorder.

Analytical and bioanalytical chemistry 20111101

Trifluoroacetic acid-promoted synthesis of 3-hydroxy, 3-amino and spirooxindoles from α-keto-N-anilides.

Organic letters 20111021

Diastereo- and enantioselective conjugate addition of 3-substituted oxindoles to nitroolefins catalyzed by a chiral Ni(OAc)2-diamine complex under mild conditions.

Organic letters 20111007

Receptor-based QSAR study for a series of 3,3-disubstituted-5-aryl oxindoles and 6-aryl benzimidazol-2-ones derivatives as progesterone receptor inhibitors.

SAR and QSAR in environmental research 20111001

Catalytic enantioselective total synthesis of hodgkinsine B.

Angewandte Chemie (International ed. in English) 20110919

Enantioselective Michael/cyclization reaction sequence: scaffold-inspired synthesis of spirooxindoles with multiple stereocenters.

Angewandte Chemie (International ed. in English) 20110919

Chiral counteranion synergistic organocatalysis under high temperature: efficient construction of optically pure spiro[cyclohexanone-oxindole] backbone.

Organic letters 20110916

Ultrasound promoted clay catalyzed efficient and one pot synthesis of substituted oxindoles.

Ultrasonics sonochemistry 20110901

Ligand polarizability contributes to tau fibril binding affinity.

Bioorganic & medicinal chemistry 20110901

Asymmetric decarboxylative allylation of oxindoles.

Organic letters 20110819

Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin.

Organic & biomolecular chemistry 20110807

Rauniticine-allo-oxindole B and rauniticinic-allo acid B, new heteroyohimbine-type oxindole alkaloids from the stems of Malaysian Uncaria longiflora var. pteropoda.

Molecules (Basel, Switzerland) 20110804

Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence.

Angewandte Chemie (International ed. in English) 20110704

Syntheses of spirocyclic oxindole-butenolides by using three-component cycloadditions of isocyanides, allenoates, and isatins.

Chemistry (Weinheim an der Bergstrasse, Germany) 20110627

Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea.

Chemical communications (Cambridge, England) 20110621

Directed oxidative cyclizations to C2- or C4-positions of indole: efficient construction of the bicyclo[4.3.1]decane core of welwitindolinones.

Organic letters 20110617

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain.

Bioorganic & medicinal chemistry letters 20110615

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.

Bioorganic & medicinal chemistry letters 20110615

Electron density of two bioactive oligocyclic indole and oxindole derivatives obtained from low-order X-ray data and invariom application.

Chemistry, an Asian journal 20110606

Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines.

European journal of medicinal chemistry 20110601

Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.

Nature chemistry 20110601

Amino-indanol-catalyzed asymmetric Michael additions of oxindoles to protected 2-amino-1-nitroethenes for the synthesis of 3,3'-disubstituted oxindoles bearing α,β-diamino functionality.

The Journal of organic chemistry 20110520

Iodo-carbocyclization of electron-deficient alkenes: synthesis of oxindoles and spirooxindoles.

Organic letters 20110506

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation.

Biochimica et biophysica acta 20110501

Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.

Oncotarget 20110501

A [3+2] dipolar cycloaddition route to 3-hydroxy-3-alkyl oxindoles: an approach to pyrrolidinoindoline alkaloids.

Organic letters 20110415

Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring.

European journal of medicinal chemistry 20110401

Flexible strategy for syntheses of spirooxindoles using palladium-catalyzed carbosilylation and Sakurai-type cyclization.

Organic letters 20110401

Chiral calcium VAPOL phosphate mediated asymmetric chlorination and Michael reactions of 3-substituted oxindoles.

Journal of the American Chemical Society 20110316

Oxindole derivatives as inhibitors of TAK1 kinase.

Bioorganic & medicinal chemistry letters 20110315

Catalytic thia-Sommelet-Hauser rearrangement: application to the synthesis of oxindoles.

Organic letters 20110304

Molybdenum-catalyzed asymmetric allylic alkylation of 3-alkyloxindoles: reaction development and applications.

Chemistry (Weinheim an der Bergstrasse, Germany) 20110301

Organocatalytic Michael-alkylation cascade: the enantioselective nitrocyclopropanation of oxindoles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20110301

Highly enantioselective catalytic benzoyloxylation of 3-aryloxindoles using chiral VAPOL calcium phosphate.

Angewandte Chemie (International ed. in English) 20110201

Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis.

Hepatology (Baltimore, Md.) 20110201

Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.

Journal of natural products 20110128

Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: facile creation of 3-hydroxy-2-oxindoles.

Organic letters 20110107

Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei.

BMC microbiology 20110101

Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives.

Chemistry Central journal 20110101

Neuroendocrine tumors of the gallbladder: a case report and review of the literature.

Journal of medical case reports 20110101

Asymmetric conjugate addition of oxindoles to 2-chloroacrylonitrile: a highly effective organocatalytic strategy for simultaneous construction of 1,3-nonadjacent stereocenters leading to chiral pyrroloindolines.

Chemistry (Weinheim an der Bergstrasse, Germany) 20101227

Indolyne experimental and computational studies: synthetic applications and origins of selectivities of nucleophilic additions.

Journal of the American Chemical Society 20101222

Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts.

Organic letters 20101217

Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation.

European journal of medicinal chemistry 20101201

Role of (68)Ga-DOTATOC PET/CT in the evaluation of primary pulmonary carcinoids.

The Korean journal of internal medicine 20101201

A myosin V inhibitor based on privileged chemical scaffolds.

Angewandte Chemie (International ed. in English) 20101102

Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles.

Organic letters 20101015

Palladium-catalyzed tandem diperoxidation/C-H activation resulting in diperoxy-oxindole in air.

Organic letters 20101015

Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone.

Angewandte Chemie (International ed. in English) 20101011

Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters.

Organic letters 20101001

Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.

Chemical communications (Cambridge, England) 20100928

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.

Bioorganic & medicinal chemistry letters 20100915

A facile method for the synthesis of oxindole based quaternary alpha-aminonitriles via the Strecker reaction.

Organic & biomolecular chemistry 20100907

Melatonin metabolism in the central nervous system.

Current neuropharmacology 20100901

Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles.

Dalton transactions (Cambridge, England : 2003) 20100821

Branch-selective synthesis of oxindole and indene scaffolds: transition metal-controlled intramolecular aryl amidation leading to c3 reverse-prenylated oxindoles.

Organic letters 20100820

First C-H activation route to oxindoles using copper catalysis.

Organic letters 20100806

Highly enantioselective construction of spiro[4H-pyran-3,3'-oxindoles] through a domino Knoevenagel/Michael/cyclization sequence catalyzed by cupreine.

Organic letters 20100716

Organocatalytic enantioselective hydroxymethylation of oxindoles with paraformaldehyde as C1 unit.

The Journal of organic chemistry 20100716

Highly diastereo- and enantioselective Michael additions of 3-substituted oxindoles to maleimides catalyzed by chiral bifunctional thiourea-tertiary amine.

Organic letters 20100702

Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.

Bioorganic & medicinal chemistry 20100701

Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins.

Organic & biomolecular chemistry 20100628

Highly enantioselective synthesis of 3-amino-2-oxindole derivatives: catalytic asymmetric alpha-amination of 3-substituted 2-oxindoles with a chiral scandium complex.

Chemistry (Weinheim an der Bergstrasse, Germany) 20100611

Oxidative dearomatization in the synthesis of erythrina, oxindole and hexahydropyrrolo[2,3-b]indole skeletons.

Chemical communications (Cambridge, England) 20100607

Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy.

The American journal of gastroenterology 20100601

Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids.

The Journal of organic chemistry 20100507

Six-component reactions for the stereoselective synthesis of 3-arylidene-2-oxindoles via sequential one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition.

The Journal of organic chemistry 20100507

Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: an organocatalytic approach to 3-hydroxyoxindole derivatives.

Journal of the American Chemical Society 20100428

An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction.

Chemical communications (Cambridge, England) 20100428

Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation.

Chemical communications (Cambridge, England) 20100414

1'-(2-Chloro-phen-yl)-5,6,5',6',7',7a'-hexa-hydro-1'H,1''H-dispiro-[imidazo[2,1-b][1,3]thia-zole-2,2'-pyrrolizine-3'(2'H),3''-indole]-2'',3(2H,3''H)-dione.

Acta crystallographica. Section E, Structure reports online 20100401

Catalytic asymmetric synthesis of 3-(alpha-hydroxy-beta-carbonyl) oxindoles by a Sc(III)-catalyzed direct aldol-type reaction.

Chemistry (Weinheim an der Bergstrasse, Germany) 20100322

Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques.

European journal of medicinal chemistry 20100301

Organocatalytic tandem reaction to construct six-membered spirocyclic oxindoles with multiple chiral centres through a formal [2+2+2] annulation.

Chemistry (Weinheim an der Bergstrasse, Germany) 20100301

Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in bimetallic vs monometallic Schiff base catalysis.

Journal of the American Chemical Society 20100203

Catalytic double stereoinduction in asymmetric allylic alkylation of oxindoles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20100104

Catalytic asymmetric synthesis of substituted 3-hydroxy-2-oxindoles.

Angewandte Chemie (International ed. in English) 20100101

Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability.

PloS one 20100101

Covalent anchoring of chloroperoxidase and glucose oxidase on the mesoporous molecular sieve SBA-15.

International journal of molecular sciences 20100101

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.

PloS one 20100101

Enantioselective synthesis of substituted oxindoles and spirooxindoles with applications in drug discovery.

Current opinion in drug discovery & development 20100101

(5''E)-1''-Benzyl-1'-methyl-5''-[4-(methyl-sulfan-yl)benzyl-idene]-4'-[4-(methyl-sulfan-yl)phen-yl]dispiro-[indoline-3,2'-pyrrolidine-3',3''-piperidine]-2,4''-dione dichloro-methane solvate.

Acta crystallographica. Section E, Structure reports online 20100101

Pitfalls in neuroendocrine tumor diagnosis.

Rare tumors 20091228

Expanding the scope of cinchona alkaloid-catalyzed enantioselective alpha-aminations of oxindoles: a versatile approach to optically active 3-amino-2-oxindole derivatives.

The Journal of organic chemistry 20091204

Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles.

Chemical communications (Cambridge, England) 20091128

(E)-3-(2,6-Dichloro-benzyl-idene)indolin-2-one.

Acta crystallographica. Section E, Structure reports online 20091101

Functionalization and rearrangement of spirocyclohexadienyl oxindoles: experimental and theoretical investigations.

Chemistry (Weinheim an der Bergstrasse, Germany) 20091026

Oxindole-Schiff base copper(II) complexes interactions with human serum albumin: spectroscopic, oxidative damage, and computational studies.

Journal of inorganic biochemistry 20091001

Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity.

Journal of the American Chemical Society 20090930

Selective synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles involving a 2-fold arene C-H activation process.

The Journal of organic chemistry 20090904

Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles.

Organic letters 20090903

Midgut neuroendocrine tumours with liver metastases: results of the UKINETS study.

Endocrine-related cancer 20090901

(E)-5-Bromo-3-(2,6-dichloro-benzyl-idene)indolin-2-one.

Acta crystallographica. Section E, Structure reports online 20090901

Access to a welwitindolinone core using sequential cycloadditions.

Organic letters 20090820

Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential.

Bioorganic & medicinal chemistry letters 20090815

Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.

Bioorganic & medicinal chemistry 20090815

Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.

Organic letters 20090806

Stereocontrolled synthesis of spirooxindoles through Lewis acid-promoted [5 + 2]-annulation of chiral silyl alcohols.

Organic letters 20090806

Antioxidant potential study of some synthesized N-heterocycles.

Bangladesh Medical Research Council bulletin 20090801

Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates.

The Journal of organic chemistry 20090717

Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates.

Chemical communications (Cambridge, England) 20090714

A homodinuclear Mn(III)2-Schiff base complex for catalytic asymmetric 1,4-additions of oxindoles to nitroalkenes.

Journal of the American Chemical Society 20090708

Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine.

Journal of the American Chemical Society 20090701

Soluble, semivolatile phenol and nitrogen compounds in milk-processing wastewaters.

Journal of dairy science 20090701

Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry.

Bioorganic & medicinal chemistry letters 20090615

Oxindole synthesis by direct C-H, Ar-H coupling.

Chemical communications (Cambridge, England) 20090614

Concise synthesis of the bicyclic scaffold of N-methylwelwitindolinone C isothiocyanate via an indolyne cyclization.

Organic letters 20090604

Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana.

Phytochemistry 20090601

5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

Journal of clinical medicine research 20090601

Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon.

Journal of the American Chemical Society 20090527

Ruthenium-catalyzed alkylation of oxindole with alcohols.

The Journal of organic chemistry 20090515

Ugi-post functionalization, from a single set of ugi-adducts to two distinct heterocycles by microwave-assisted palladium-catalyzed cyclizations: tuning the reaction pathways by ligand switch.

The Journal of organic chemistry 20090417

The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20090412

Synthesis of oxindoles by tandem Heck-reduction-cyclization (HRC) from a single bifunctional, in situ generated Pd/C catalyst.

The Journal of organic chemistry 20090206

(Z)-3-[(E)-3-Phenyl-allyl-idene]indolin-2-one.

Acta crystallographica. Section E, Structure reports online 20090201

rac-(4R,17S,18R,26R)-Ethyl 4'-methoxy-carbonyl-5''-(4-methoxy-phen-yl)-1'-methyl-2,3''-dioxo-2'',3''-dihydro-indoline-3-spiro-2'-pyrrolidine-3'-spiro-2''-thia-zolo[3,2-a]pyrimidine-6''-carboxyl-ate.

Acta crystallographica. Section E, Structure reports online 20090201

AcOLeDMAP and BnOLeDMAP: conformationally restricted nucleophilic catalysts for enantioselective rearrangement of indolyl acetates and carbonates.

Journal of the American Chemical Society 20090114

The discovery of highly potent CGRP receptor antagonists.

Bioorganic & medicinal chemistry letters 20090101

Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H centers.

Angewandte Chemie (International ed. in English) 20090101

Targeting structural and stereochemical complexity by organocascade catalysis: construction of spirocyclic oxindoles having multiple stereocenters.

Angewandte Chemie (International ed. in English) 20090101

Catalytic enantioselective stereoablative alkylation of 3-halooxindoles: facile access to oxindoles with C3 all-carbon quaternary stereocenters.

Angewandte Chemie (International ed. in English) 20090101

A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication.

BMC microbiology 20090101

Stereoselective synthesis of 3-alkylideneoxindoles by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents.

Organic letters 20081106

(13)C, (15)N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from Cat's Claw (Uncaria tomentosa).

Solid state nuclear magnetic resonance 20081101

Rearrangement of spirocyclic oxindoles with lithium amide bases.

Organic letters 20081016

Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments.

Organic letters 20080918

Stereoselective oxidative rearrangement of 2-aryl tryptamine derivatives.

Organic letters 20080918

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis.

Chemical communications (Cambridge, England) 20080914

Intermolecular enolate heterocoupling: scope, mechanism, and application.

Journal of the American Chemical Society 20080827

Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles.

Organic letters 20080821

Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation.

Organic letters 20080807

Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles.

Journal of the American Chemical Society 20080723

Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: selective synthesis of 3-(1-arylmethylene)oxindoles.

The Journal of organic chemistry 20080718

Facile and general synthesis of quaternary 3-aminooxindoles.

Organic letters 20080703

Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process.

Organic letters 20080501

Palladium-catalyzed alpha-arylation of oxindoles.

Organic letters 20080403

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

Journal of medicinal chemistry 20080327

Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity.

Journal of inorganic biochemistry 20080101

Biotransformation of indole derivatives by mycelial cultures.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles.

Angewandte Chemie (International ed. in English) 20080101

Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV.

Nucleic acids symposium series (2004) 20080101

Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles.

Journal of the American Chemical Society 20071128

Potent oxindole based human beta3 adrenergic receptor agonists.

Bioorganic & medicinal chemistry letters 20071115

Enantioselective construction of spirocyclic oxindolic cyclopentanes by palladium-catalyzed trimethylenemethane-[3+2]-cycloaddition.

Journal of the American Chemical Society 20071017

Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition.

Organic letters 20071011

[Association between the TPH2 gene and suicidal behavior].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20071001

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.

FEBS letters 20070918

Straightforward stereoselective synthesis of spiro-epoxyoxindoles.

Organic letters 20070426

Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20070401

Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation.

The Journal of organic chemistry 20070330

Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata.

Molecules (Basel, Switzerland) 20070206

Structure-activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines.

Analytica chimica acta 20070109

Simple and one-pot protocol for synthesis of indene-spiro-oxindoles involving tandem Prins and Friedel-Crafts reactions.

Organic letters 20070104

3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101

A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles.

Journal of combinatorial chemistry 20070101

Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate.

Angewandte Chemie (International ed. in English) 20070101

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.

Journal of neural transmission. Supplementum 20070101

Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and beta-keto esters using DBFOX ligand.

Journal of the American Chemical Society 20061227

Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures.

Journal of the American Chemical Society 20061220

Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates.

The Journal of organic chemistry 20061027

An efficient synthesis of a spirocyclic oxindole analogue.

Molecules (Basel, Switzerland) 20060914

Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2.

The Journal of organic chemistry 20060818

Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.

Bioorganic & medicinal chemistry letters 20060701

Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.

Biochemistry 20060418

Selective kinase inhibition by exploiting differential pathway sensitivity.

Chemistry & biology 20060401

Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular Heck reaction.

The Journal of organic chemistry 20060331

Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement.

Angewandte Chemie (International ed. in English) 20060327

Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene.

The Journal of organic chemistry 20060203

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.

Journal of medicinal chemistry 20060126

A new chemical tool for exploring the physiological function of the PDE2 isozyme.

Bioorganic & medicinal chemistry letters 20060115

Liver metastases of neuroendocrine tumours; early reduction of tumour load to improve life expectancy.

World journal of surgical oncology 20060101

Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40).

Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging.

The Biochemical journal 20050915

Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions.

The Journal of organic chemistry 20050819

Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma.

Journal of immunology (Baltimore, Md. : 1950) 20050301

Recent developments on KCNQ potassium channel openers.

Current medicinal chemistry 20050101

Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles.

Angewandte Chemie (International ed. in English) 20041227

Involvement of photooxidation of melanogenic precursors in prolonged pigmentation induced by ultraviolet A.

The Journal of investigative dermatology 20040201

[Effects of 3-substituted aryl oxindole(PH II-7) on cell cycle of tumor cells].

Yao xue xue bao = Acta pharmaceutica Sinica 20031101

Prooxidant activity of free radicals derived from phenol-containing neurotransmitters.

Toxicology 20020801

Efficient formal total synthesis of physostigmine and physovenine: conformational analysis of key intermediates.

Journal of natural products 20020201

[Effect of oxidized indoles on monoamine oxidase activity in the rat brain mitochondria].

Voprosy meditsinskoi khimii 20020101

Expression of the Caldariomyces fumago chloroperoxidase in Aspergillus niger and characterization of the recombinant enzyme.

The Journal of biological chemistry 20010525

Chloroperoxidase-catalyzed enantioselective oxidations in hydrophobic organic media.

Biotechnology and bioengineering 20010305

Crystal structure of a conformation-selective casein kinase-1 inhibitor.

The Journal of biological chemistry 20000630

Characterization of novel inhibitors of cyclin-dependent kinases.

Biochemical and biophysical research communications 19990714