PMPA(NAALADaseinhibitor)
| Title | Journal |
|---|---|
| NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia. | Translational psychiatry 20120701 |
| Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia. | The Journal of biological chemistry 20120622 |
| Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. | Amino acids 20120601 |
| mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia. | Schizophrenia research 20120401 |
| Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia. | Psychopharmacology 20110701 |
| Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies. | Journal of translational medicine 20110101 |
| Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101 |
| Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. | The Prostate 20100215 |
| Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. | European journal of pharmacology 20100210 |
| N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. | Neuropharmacology 20100101 |
| Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. | Journal of neurochemistry 20100101 |
| GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. | Journal of neurovirology 20090901 |
| Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting. | Journal of medicinal chemistry 20090122 |
| Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks. | European journal of pharmacology 20080128 |
| Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. | Molecular pain 20080101 |
| Progress in the discovery and development of glutamate carboxypeptidase II inhibitors. | Drug discovery today 20070901 |
| Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. | Journal of medicinal chemistry 20070712 |
| Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA. | Acta crystallographica. Section D, Biological crystallography 20070401 |
| Design, synthesis and pharmacological activity of novel enantiomerically pure phosphonic acid-based NAALADase inhibitors. | Organic & biomolecular chemistry 20070307 |
| Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. | Journal of neurochemistry 20070101 |
| Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. | The European journal of neuroscience 20070101 |
| Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration. | Neuropharmacology 20061201 |
| Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity. | Neuroscience 20060811 |
| Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro. | The Prostate 20060601 |
| Complex character analysis of heart rate variability following brain asphyxia. | Medical engineering & physics 20060501 |
| 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. | European journal of pharmacology 20060215 |
| Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy. | Advances in experimental medicine and biology 20060101 |
| 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice. | Psychopharmacology 20051201 |
| Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat. | Journal of neurochemistry 20050701 |
| Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors. | Journal of neurochemistry 20050501 |
| Enantiospecificity of glutamate carboxypeptidase II inhibition. | Journal of medicinal chemistry 20050407 |
| Inhibition of glutamate carboxypeptidase II (NAALADase) protects against dynorphin A-induced ischemic spinal cord injury in rats. | European journal of pharmacology 20050131 |
| 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. | Journal of molecular neuroscience : MN 20050101 |
| N-Acetylated alpha-linked acidic dipeptidase expressed in rat adipocytes is localized in the insulin-responsive glucose transporter (GLUT4) intracellular compartments and involved in the insulin-stimulated GLUT4 recruitment. | Archives of biochemistry and biophysics 20040401 |
| Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. | Journal of neurochemistry 20040401 |
| Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. | Journal of medicinal chemistry 20040325 |
| Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat. | Neuropeptides 20031001 |
| Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. | Bioorganic & medicinal chemistry letters 20030707 |
| NAALADase inhibition protects motor neurons against chronic glutamate toxicity. | European journal of pharmacology 20030627 |
| Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. | Journal of medicinal chemistry 20030508 |
| Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301 |
| Glutamate carboxypeptidase II inhibition as a novel therapeutic target. | Advances in experimental medicine and biology 20030101 |
| Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay. | Analytical biochemistry 20021101 |
| Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. | Journal of neurochemistry 20021001 |
| Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. | Journal of medicinal chemistry 20020912 |
| NAALADase (GCP II) inhibition prevents cocaine-kindled seizures. | Neuropharmacology 20020901 |
| Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia. | European journal of pharmacology 20020222 |
| Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. | The Journal of pharmacology and experimental therapeutics 20020201 |
| 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase). | Molecular imaging 20020101 |
| Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta. | European journal of pharmacology 20011026 |
| Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes. | European journal of pharmacology 20010914 |
| Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation. | European journal of pharmacology 20010824 |
| Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat. | Brain research 20010803 |
| Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE). | Synapse (New York, N.Y.) 20010701 |
| Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). | Journal of medicinal chemistry 20010201 |
| Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test. | Neuroscience 20010101 |
| N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber. | Neuroscience 20010101 |
| Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling. | Neuroscience 20010101 |