Home Other Building Blocks PIPAMPERONE DIHYDROCHLORIDE APPROX. 99

PIPAMPERONE DIHYDROCHLORIDE APPROX. 99

CAS No.:
1893-33-0
Catalog Number:
AG00AK7X
Molecular Formula:
Molecular Weight:
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Purity
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Product Description
Catalog Number:
AG00AK7X
Chemical Name:
PIPAMPERONE DIHYDROCHLORIDE APPROX. 99
CAS Number:
1893-33-0
MDL Number:
MFCD00242979
IUPAC Name:
1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide
InChI:
InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)
InChI Key:
AXKPFOAXAHJUAG-UHFFFAOYSA-N
UNII:
5402501F0W
NSC Number:
759178
Properties
Complexity:
506  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
375.232g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
375.488g/mol
Monoisotopic Mass:
375.232g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
66.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2  
Literature
Title Journal
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Auditing clinical outcomes after introducing off-licence prescribing of atypical antipsychotic melperone for patients with treatment refractory schizophrenia. TheScientificWorldJournal 20120101
Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response. Psychological medicine 20111001
[Loss of visual acuity after treatment with pipamperone]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20110801
[A patient suffering from priapism as a side-effect of pipamperone]. Nederlands tijdschrift voor geneeskunde 20110101
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Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Antipsychotics and risk of venous thromboembolism: A population-based case-control study. Clinical epidemiology 20090101
Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain. Nuclear medicine communications 20080801
Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters. Journal of the American Society for Mass Spectrometry 20080501
[Recurrent dysregulation of body temperature during antipsychotic pharmacotherapy]. Psychiatrische Praxis 20080301
Validation of a solid-phase extraction and liquid chromatography-electrospray tandem mass spectrometric method for the determination of nine basic pharmaceuticals in wastewater and surface water samples. Journal of chromatography. A 20080227
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry 20080124
[Pipamperone and the treatment of impulsive aggressive behaviour]. Tijdschrift voor psychiatrie 20080101
The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry 20080101
[Enuresis in therapy with psychotropic drugs]. Praxis 20070905
Hypothermia following antipsychotic drug use. European journal of clinical pharmacology 20070601
Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen. Arzneimittel-Forschung 20070101
Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. Life sciences 20061203
Management of a severe forceful breather with Rett syndrome using carbogen. Brain & development 20061101
Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020
Tackling matrix effects during development of a liquid chromatographic-electrospray ionisation tandem mass spectrometric analysis of nine basic pharmaceuticals in aqueous environmental samples. Journal of chromatography. A 20060804
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. No to shinkei = Brain and nerve 20060601
Stability indicating LC method for the determination of pipamperone. Journal of pharmaceutical and biomedical analysis 20051004
Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling. BMC bioinformatics 20050101
In-patient psychiatric-psychotherapeutic treatment of mothers with a generalized anxiety disorder--does the co-admission of their children influence the treatment results? A prospective, controlled study. Wiener klinische Wochenschrift 20041130
Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry. Clinical chemistry and laboratory medicine 20031201
Quantitative determination of piritramide in human serum applying liquid chromatography-two-stage mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105
Differential-pulse polarography determination of pipamperone in pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis 20021107
Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats. Behavioural pharmacology 20020701
Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction. Journal of analytical toxicology 20020401
[Models of drug treatment in the attention deficit disorder with hyperactivity]. Revista de neurologia 20020201
Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state. Naunyn-Schmiedeberg's archives of pharmacology 20020101
Pharmacokinetics of pipamperone from three different tablet formulations. Arzneimittel-Forschung 20020101
Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. European journal of pharmacology 20010803
Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs. European journal of clinical pharmacology 20010701
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain research 20010126
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 19960301
Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone. Arzneimittel-Forschung 19940301
Properties