4(3H)-Pyrimidinone, 2,6-diamino- (9CI)
| Title | Journal |
|---|---|
| Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites. | Acta crystallographica. Section B, Structural science 20120801 |
| Cocrystals of 5-fluorocytosine. II. Coformers with variable hydrogen-bonding sites. | Acta crystallographica. Section B, Structural science 20120801 |
| Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells. | International journal of cardiology 20120405 |
| Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall: Early and Late Ascorbic Acid Supplementation. | International journal of vascular medicine 20120101 |
| Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. | American journal of physiology. Heart and circulatory physiology 20111101 |
| Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase. | Journal of medicinal chemistry 20111027 |
| Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. | Hypertension (Dallas, Tex. : 1979) 20110801 |
| Pseudopolymorphs of 2,6-diaminopyrimidin-4-one and 2-amino-6-methylpyrimidin-4-one: one or two tautomers present in the same crystal. | Acta crystallographica. Section C, Crystal structure communications 20110501 |
| Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives. | Bioorganic & medicinal chemistry letters 20110301 |
| Two new polymorphs of 2,6-diaminopyrimidin-4(3H)-one monohydrate. | Acta crystallographica. Section C, Crystal structure communications 20110101 |
| Validity of urinary monoamine assay sales under the 'spot baseline urinary neurotransmitter testing marketing model'. | International journal of nephrology and renovascular disease 20110101 |
| 2,6-Diamino-4-oxo-3,4-dihydropyrim-idin-1-ium chloride dihydrate. | Acta crystallographica. Section E, Structure reports online 20100901 |
| Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. | Bioorganic & medicinal chemistry 20100715 |
| Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. | Bioorganic & medicinal chemistry 20100515 |
| Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. | American journal of physiology. Gastrointestinal and liver physiology 20100501 |
| Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. | PLoS pathogens 20100401 |
| Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. | Journal of medicinal chemistry 20100211 |
| Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. | American journal of physiology. Heart and circulatory physiology 20091101 |
| DFT simulations and vibrational analysis of FT-IR and FT-Raman spectra of 2,4-diamino-6-hydroxypyrimidine. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090815 |
| A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy. | Organic letters 20090604 |
| Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. | Hypertension (Dallas, Tex. : 1979) 20090601 |
| Highly diastereoselective domino synthesis of 6-spirosubstituted pyrido[2,3-d]pyrimidine derivatives in water. | Journal of combinatorial chemistry 20090101 |
| Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. | Hypertension (Dallas, Tex. : 1979) 20080901 |
| Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats. | Journal of hepatology 20080801 |
| Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. | Journal of pharmacological sciences 20080501 |
| 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. | Biochimica et biophysica acta 20080101 |
| Regulation of tetrahydrobiopterin biosynthesis by shear stress. | Circulation research 20071012 |
| Alu recombination-mediated structural deletions in the chimpanzee genome. | PLoS genetics 20071001 |
| An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives. | Organic & biomolecular chemistry 20070507 |
| C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation. | Journal of vascular research 20070101 |
| Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. | European journal of pharmacology 20060120 |
| Neural tube closure depends on nitric oxide synthase activity. | Journal of neurochemistry 20060101 |
| Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats. | Menopause (New York, N.Y.) 20060101 |
| Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety. | Arzneimittel-Forschung 20060101 |
| Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. | Brain research. Molecular brain research 20051207 |
| Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke. | Stroke 20051201 |
| Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. | Journal of neurochemistry 20051001 |
| Crystal structure and luminescence of lanthanide monodentate complexes [Ln(C(4)N(4)H(6)O)(2)(H(2)O)(6)]Cl(3) and [Ln(C(4)N(4)H(6)O)(2)(H(2)O)(3)(NO(3))(3)] (Ln = Tb or Eu). | Inorganic chemistry 20050613 |
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. | Journal of medicinal chemistry 20041230 |
| Effect of tetrahydrobiopterin on nitric oxide synthase-containing cells in the rat hippocampus. | Neuroscience research 20041001 |
| The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein. | The Journal of biological chemistry 20040924 |
| A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines. | The Journal of organic chemistry 20031226 |
| Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells. | The Journal of biological chemistry 20031212 |
| Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases. | Bioorganic & medicinal chemistry 20031117 |
| GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. | American journal of physiology. Heart and circulatory physiology 20031101 |
| Exogenous biopterins requirement for iNOS function in vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20030801 |
| Kainic acid lesion-induced nigral neuronal death. | Journal of chemical neuroanatomy 20030801 |
| Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. | The Journal of biological chemistry 20030620 |
| Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. | Journal of neurochemistry 20030401 |
| HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20030201 |
| Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. | The Journal of cardiovascular surgery 20030201 |
| Wavelength-dependent induction of a mycosporine-like amino acid in a rice-field cyanobacterium, Nostoc commune: role of inhibitors and salt stress. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20030201 |
| Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies. | Bioorganic & medicinal chemistry 20030102 |
| Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts. | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20030101 |
| Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. | Journal of vascular research 20030101 |
| Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats. | Critical care medicine 20021101 |
| Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. | The international journal of biochemistry & cell biology 20020901 |
| Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. | Journal of neurochemistry 20020901 |
| Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells. | Neuroscience letters 20020809 |
| Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. | Brain research 20020510 |
| Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. | British journal of pharmacology 20020501 |
| 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. | Journal of medicinal chemistry 20020425 |
| Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. | Cytokine 20020421 |
| [The protective effects and its underlying mechanism of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats]. | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20020401 |
| 2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum. | BMC gastroenterology 20020101 |
| A new one-pot three-component condensation reaction for the synthesis of 5-deaza-5,8-dihydropterins. | Chemical communications (Cambridge, England) 20011207 |
| Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells. | Biochemical and biophysical research communications 20011130 |
| Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. | Japanese journal of pharmacology 20010901 |
| Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. | The Journal of laboratory and clinical medicine 20010501 |
| Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. | The international journal of biochemistry & cell biology 20010101 |
| Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. | Journal of the American Society of Nephrology : JASN 19950201 |