KRN7000
| Title | Journal |
|---|---|
| Chronic alcohol consumption enhances iNKT cell maturation and activation. | Toxicology and applied pharmacology 20150115 |
| Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection. | Journal of immunology (Baltimore, Md. : 1950) 20130915 |
| Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells. | Journal of immunology (Baltimore, Md. : 1950) 20130901 |
| Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis. | The American journal of pathology 20130201 |
| Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. | Proceedings of the National Academy of Sciences of the United States of America 20130129 |
| Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. | PloS one 20130101 |
| CD1d-dependent, iNKT-cell cytotoxicity against keratinocytes in allergic contact dermatitis. | Experimental dermatology 20121201 |
| Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex. | The Journal of biological chemistry 20121109 |
| The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. | PLoS biology 20121001 |
| Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide. | The Journal of infectious diseases 20120901 |
| Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. | Nature immunology 20120901 |
| C-Glycosphingolipids with an exo-methylene substituent: stereocontrolled synthesis and immunostimulation of mouse and human natural killer T lymphocytes. | Chembiochem : a European journal of chemical biology 20120813 |
| RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines. | Bioorganic & medicinal chemistry 20120715 |
| Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. | Proceedings of the National Academy of Sciences of the United States of America 20120508 |
| Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic Lactobacillus, Staphylococcus and Streptococcus species. | Glycoconjugate journal 20120501 |
| Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. | The EMBO journal 20120418 |
| Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. | Journal of immunology (Baltimore, Md. : 1950) 20120301 |
| 3-fluoro- and 3,3-difluoro-3,4-dideoxy-KRN7000 analogues as new potent immunostimulator agents: total synthesis and biological evaluation in human invariant natural killer T cells and mice. | Journal of medicinal chemistry 20120209 |
| Structural basis for the recognition of C20:2-αGalCer by the invariant natural killer T cell receptor-like antibody L363. | The Journal of biological chemistry 20120106 |
| Natural variations at position 93 of the invariant Vα24-Jα18 α chain of human iNKT-cell TCRs strongly impact on CD1d binding. | European journal of immunology 20120101 |
| Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. | PloS one 20120101 |
| Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. | PloS one 20120101 |
| Divergent synthetic approach to 6''-modified α-GalCer analogues. | Organic & biomolecular chemistry 20111221 |
| Total synthesis of α-1C-galactosylceramide, an immunostimulatory C-glycosphingolipid, and confirmation of the stereochemistry in the first-generation synthesis. | The Journal of organic chemistry 20111104 |
| Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20111101 |
| Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area. | Diabetes/metabolism research and reviews 20111101 |
| Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. | PLoS biology 20111101 |
| Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. | Nature immunology 20111001 |
| Cutting edge: structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells. | Journal of immunology (Baltimore, Md. : 1950) 20110901 |
| Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. | Nature immunology 20110731 |
| A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. | Nature immunology 20110612 |
| Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. | The Journal of experimental medicine 20110606 |
| Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. | The EMBO journal 20110601 |
| Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model. | Journal of clinical immunology 20110401 |
| A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. | Immunity 20110325 |
| A molecular basis for NKT cell recognition of CD1d-self-antigen. | Immunity 20110325 |
| Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids. | The Journal of organic chemistry 20110107 |
| Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. | Bioorganic & medicinal chemistry 20110101 |
| Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. | Arteriosclerosis, thrombosis, and vascular biology 20100901 |
| Synthesis and biological activity of ester and ether analogues of alpha-galactosylceramide (KRN7000). | Carbohydrate research 20100816 |
| Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. | Journal of immunology (Baltimore, Md. : 1950) 20100815 |
| Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. | Journal of lipid research 20100701 |
| Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production. | Journal of immunology (Baltimore, Md. : 1950) 20100701 |
| Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function. | Journal of immunology (Baltimore, Md. : 1950) 20100701 |
| Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. | Bioorganic & medicinal chemistry letters 20100601 |
| Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. | The Journal of clinical investigation 20100601 |
| Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop. | PLoS biology 20100601 |
| CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. | Infection and immunity 20100401 |
| A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. | Journal of immunology (Baltimore, Md. : 1950) 20100215 |
| Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry. | Bioorganic & medicinal chemistry letters 20100201 |
| Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. | Proceedings of the National Academy of Sciences of the United States of America 20100126 |
| PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. | Mucosal immunology 20100101 |
| Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. | Journal of immunology (Baltimore, Md. : 1950) 20100101 |
| Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. | PLoS pathogens 20090901 |
| Focus on the controversial activation of human iNKT cells by 4-deoxy analogue of KRN7000. | Journal of medicinal chemistry 20090813 |
| Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. | Bioorganic & medicinal chemistry letters 20090801 |
| Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions. | Journal of immunology (Baltimore, Md. : 1950) 20090801 |
| Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. | Immunity 20090717 |
| Cutting edge: B and T lymphocyte attenuator signaling on NKT cells inhibits cytokine release and tissue injury in early immune responses. | Journal of immunology (Baltimore, Md. : 1950) 20090701 |
| Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. | Journal of immunology (Baltimore, Md. : 1950) 20090415 |
| Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation. | Bioorganic & medicinal chemistry letters 20081215 |
| Synthesis of alpha-galactosyl ceramide (KRN7000) and analogues thereof via a common precursor and their preliminary biological assessment. | The Journal of organic chemistry 20081121 |
| Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000. | Organic letters 20081016 |
| The first synthesis of a thioglycoside analogue of the immunostimulant KRN7000. | Organic letters 20081016 |
| RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines. | Bioorganic & medicinal chemistry 20081001 |
| Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. | Transplantation 20080815 |
| Alpha-lactosylceramide as a novel 'sugar-capped' CD1d ligand for natural killer T cells: biased cytokine profile and therapeutic activities. | Chembiochem : a European journal of chemical biology 20080616 |
| Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers. | European journal of immunology 20080401 |
| RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. | Bioorganic & medicinal chemistry 20080115 |
| Immunization with dendritic cells loaded with alpha-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria. | FEMS immunology and medical microbiology 20071101 |
| iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. | Journal of immunology (Baltimore, Md. : 1950) 20071001 |
| A general and stereoselective route to alpha- or beta-galactosphingolipids via a common four-carbon building block. | The Journal of organic chemistry 20070928 |
| A Y chromosome-linked factor impairs NK T development. | Journal of immunology (Baltimore, Md. : 1950) 20070915 |
| CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. | Nature 20070705 |
| Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. | Bioorganic & medicinal chemistry letters 20070515 |
| Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant alpha-GalCer. | Journal of medicinal chemistry 20070208 |
| During acute Trypanosoma cruzi infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment. | Immunology 20061101 |
| The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. | Immunology 20060901 |
| Synthesis and biological evaluation of alpha-galactosylceramide (KRN7000) and isoglobotrihexosylceramide (iGb3). | Bioorganic & medicinal chemistry letters 20060415 |
| Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. | Proceedings of the National Academy of Sciences of the United States of America 20060314 |
| Chemoenzymatic syntheses of iGb3 and Gb3. | Organic letters 20060302 |
| Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | The Journal of organic chemistry 20051209 |
| NK T cell activation promotes Chlamydia trachomatis infection in vivo. | Journal of immunology (Baltimore, Md. : 1950) 20050901 |
| The crystal structure of human CD1d with and without alpha-galactosylceramide. | Nature immunology 20050801 |
| Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. | Nature immunology 20050801 |
| Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. | The Journal of experimental medicine 20050502 |
| Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. | Journal of immunology (Baltimore, Md. : 1950) 20040915 |
| Enhancement of the synthetic ligand-mediated function of liver NK1.1Ag+ T cells in mice by interleukin-12 pretreatment. | Immunology 20040901 |
| Human NKT cells express granulysin and exhibit antimycobacterial activity. | Journal of immunology (Baltimore, Md. : 1950) 20030315 |
| Total enantioselective synthesis and in vivo biological evaluation of a novel fluorescent BODIPY alpha-galactosylceramide. | Chembiochem : a European journal of chemical biology 20030103 |
| No inhibition of urinary bladder carcinogenesis in rats with intravesical instillation of alpha-galactosylceramide. | Asian Pacific journal of cancer prevention : APJCP 20030101 |
| Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. | Proceedings of the National Academy of Sciences of the United States of America 20021224 |
| Enhancing effects of (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-2-(N-hexacosanoylamino) -1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000-pretreated antigen-presenting cells. | Oncology research 19960101 |
| Characterization of neutral glycosphingolipids in rat lens. | Experimental eye research 19950201 |
| KRN7000, a novel immunomodulator, and its antitumor activities. | Oncology research 19950101 |