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Home Other Building Blocks 2-Hydroxy Desipramine

2-Hydroxy Desipramine

CAS No.:
1977-15-7
Catalog Number:
AG00ADZU
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00ADZU
Chemical Name:
2-Hydroxy Desipramine
CAS Number:
1977-15-7
MDL Number:
MFCD00871819
IUPAC Name:
11-[3-(methylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
InChI:
InChI=1S/C18H22N2O/c1-19-11-4-12-20-17-6-3-2-5-14(17)7-8-15-13-16(21)9-10-18(15)20/h2-3,5-6,9-10,13,19,21H,4,7-8,11-12H2,1H3
InChI Key:
NVJBOLMRGMDGLD-UHFFFAOYSA-N
UNII:
VO1Y07E90C
Properties
Complexity:
322  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
282.173g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
282.387g/mol
Monoisotopic Mass:
282.173g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
35.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.5  
Literature
Title Journal
The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults. Journal of clinical pharmacology 20090201
An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects. Drug metabolism and disposition: the biological fate of chemicals 20081201
Effect of the novel anxiolytic drug deramciclane on cytochrome P(450) 2D6 activity as measured by desipramine pharmacokinetics. European journal of clinical pharmacology 20040201
Effect of tolcapone on the haemodynamic effects and tolerability of desipramine. European neurology 20000101
2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults. Journal of clinical psychopharmacology 19910401
Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics. Archives of general psychiatry 19820901
Properties