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Rapacuronium

CAS No.:
156137-99-4
Catalog Number:
AG00ADAV
Molecular Formula:
C37H61BrN2O4
Molecular Weight:
677.7952
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$543
- +
10mg
98%
1 week
United States
$821
- +
25mg
98%
1 week
United States
$1585
- +
50mg
98%
1 week
United States
$2279
- +
100mg
98%
1 week
United States
$3668
- +
Product Description
Catalog Number:
AG00ADAV
Chemical Name:
Rapacuronium
CAS Number:
156137-99-4
Molecular Formula:
C37H61BrN2O4
Molecular Weight:
677.7952
MDL Number:
MFCD00870871
IUPAC Name:
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;bromide
InChI:
InChI=1S/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1
InChI Key:
LVQTUXZKLGXYIU-GWSNJHLMSA-M
SMILES:
C=CC[N+]1(CCCCC1)[C@H]1C[C@@H]2[C@]([C@H]1OC(=O)CC)(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)C[C@@H]([C@H](C2)OC(=O)C)N1CCCCC1.[Br-]
UNII:
65Q4QDG4KC
Properties
Complexity:
1030  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
676.381g/mol
Formal Charge:
0
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
677.809g/mol
Monoisotopic Mass:
676.381g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
55.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Determining the potency of neuromuscular blockers: are traditional methods flawed? British journal of anaesthesia 20100601
Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology 20100401
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors. BMC pharmacology 20090101
Performance of an iterative two-stage bayesian technique for population pharmacokinetic analysis of rich data sets. Pharmaceutical research 20061201
Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. Anesthesiology 20051201
Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesthesia and analgesia 20050901
Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. Anesthesiology 20050101
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101
[The time-course of action of rapacuronium and mivacurium after early reversal following equally lasting relaxation]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20030901
A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism. Anesthesiology 20030401
Rapacuronium: premarket drug evaluation can be very effective for the identification of drug risks. Anesthesia and analgesia 20030201
Does the choice of intravenous induction drug affect intubation conditions after a fast-onset neuromuscular blocker? Journal of clinical anesthesia 20030201
Priming rapacuronium: a comparison with rocuronium and mivacurium. Acta cientifica venezolana 20030101
Neuromuscular effects of rapacuronium on the diaphragm and skeletal muscles in anaesthetized patients using cervical magnetic stimulation for stimulating the phrenic nerves. European journal of anaesthesiology 20021201
Effect of maintenance bolus on the recovery profile of a short-acting nondepolarizing muscle relaxant. Journal of clinical anesthesia 20021101
Further comments on the withdrawal of rapacuronium. Anesthesia and analgesia 20021001
The effect on lung mechanics in anesthetized children with rapacuronium: a comparative study with mivacurium. Anesthesia and analgesia 20020701
Another possible mechanism for bronchospasm after rapacuronium. Anesthesiology 20020601
Which formulation of propofol was used? Anesthesiology 20020601
The hemodynamic effects of rapacuronium in patients with coronary artery disease: succinylcholine and vecuronium compared. Anesthesia and analgesia 20020501
A comparison of neuromuscular effects, tracheal intubating conditions, and reversibility of rapacuronium versus mivacurium in female patients. Anesthesia and analgesia 20020401
Rapacuronium redux. Anesthesia and analgesia 20020301
Rapacuronium and the risk of bronchospasm in pediatric patients. Anesthesia and analgesia 20020301
The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors. Anesthesia and analgesia 20020301
Tracheal intubation conditions and cardiovascular effects after modified rapid-sequence induction with sevoflurane-rapacuronium versus propofol-rapacuronium. Journal of clinical anesthesia 20020301
Rapacuronium: why did it fail as a replacement for succinylcholine? British journal of anaesthesia 20020201
Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium. Anesthesia and analgesia 20020101
Pharmacokinetics and pharmacodynamics of rapacuronium bromide. Clinical pharmacokinetics 20020101
[New muscle relaxants]. Masui. The Japanese journal of anesthesiology 20011201
Rapacuronium for neuromuscular blockade in two myasthenic patients undergoing trans-sternal thymectomy. European journal of anaesthesiology 20011101
Use of rapacuronium in a child with spinal muscular atrophy. Paediatric anaesthesia 20011101
Reexamined: the recommended endotracheal intubating dose for nondepolarizing neuromuscular blockers of rapid onset. Anesthesia and analgesia 20011001
Effects of rapacuronium on respiratory function during general anesthesia: a comparison with cis-atracurium. Anesthesiology 20011001
A multicenter evaluation of the time-course of action of two doses of rapacuronium after early and late reversal with neostigmine. Anesthesia and analgesia 20010801
Rapacuronium administration to patients receiving phenytoin or carbamazepine. Journal of neurosurgical anesthesiology 20010701
Precipitation of thiopental by rapacuronium. Anesthesiology 20010701
Rapacuronium: an alternative to succinylcholine for electroconvulsive therapy. Anesthesia and analgesia 20010501
Duration of action of vecuronium after an intubating dose of rapacuronium, vecuronium, or succinylcholine. Anesthesia and analgesia 20010501
Rapacuronium and bronchospasm. Anesthesiology 20010501
Severe bronchospasm and desaturation in a child associated with rapacuronium. Anesthesiology 20010501
How serious is the bronchospasm induced by rapacuronium? Anesthesiology 20010501
Bronchospasm after rapacuronium in infants and children. Anesthesiology 20010501
No substitute for the intravenous route. Anesthesiology 20010101
Intramuscular rapacuronium in infants and children: a comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects. Anesthesiology 20010101
Newer neuromuscular blocking agents: how do they compare with established agents? Drugs 20010101
'Rap' in the streets: a retrospective look at the use of rapacuronium for prehospital rapid sequence induction. Air medical journal 20010101
Recent advances in myorelaxant therapy. Paediatric anaesthesia 20010101
Muscle relaxants in paediatric day case surgery. European journal of anaesthesiology. Supplement 20010101
Choice of the hypnotic and the opioid for rapid-sequence induction. European journal of anaesthesiology. Supplement 20010101
Choice of the muscle relaxant for rapid-sequence induction. European journal of anaesthesiology. Supplement 20010101
Rapacuronium: clinical pharmacology. European journal of anaesthesiology. Supplement 20010101
A pharmacokinetic-dynamic explanation of the rapid onset-offset of rapacuronium. European journal of anaesthesiology. Supplement 20010101
Rapacuronium: first experience in clinical practice. European journal of anaesthesiology. Supplement 20010101
Properties