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PD-149163

CAS No.:
169528-11-4
Catalog Number:
AG00AD80
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00AD80
Chemical Name:
PD-149163
CAS Number:
169528-11-4
MDL Number:
MFCD07772286
IUPAC Name:
ethyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2,6-diaminohexyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoate
InChI:
InChI=1S/C42H71N9O6/c1-7-57-41(56)34(23-27(2)3)49-39(54)36(42(4,5)6)50-37(52)33(24-28-25-46-31-17-9-8-16-30(28)31)48-38(53)35-19-14-22-51(35)40(55)32(18-11-13-21-44)47-26-29(45)15-10-12-20-43/h8-9,16-17,25,27,29,32-36,46-47H,7,10-15,18-24,26,43-45H2,1-6H3,(H,48,53)(H,49,54)(H,50,52)/t29-,32-,33-,34-,35-,36+/m0/s1
InChI Key:
LVROVYGTQUFAMB-IDESOYSGSA-N
Properties
Complexity:
1280  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
797.553g/mol
Formal Charge:
0
Heavy Atom Count:
57  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0
Molecular Weight:
798.087g/mol
Monoisotopic Mass:
797.553g/mol
Rotatable Bond Count:
26  
Topological Polar Surface Area:
240A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. European journal of pain (London, England) 20120401
The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20110701
Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats. Behavioral neuroscience 20110401
A neurotensin agonist and antagonist decrease and increase activity, respectively, but do not preclude discrete cue conditioning. Journal of psychopharmacology (Oxford, England) 20100301
The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature. Neuropharmacology 20100101
The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090701
The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance. Psychopharmacology 20081001
The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle. Pharmacology, biochemistry, and behavior 20081001
Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion. Journal of psychopharmacology (Oxford, England) 20080501
Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect. Journal of psychopharmacology (Oxford, England) 20080501
Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine. Pain 20080401
The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behavioural brain research 20070806
Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behavioural pharmacology 20060601
The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041001
Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonist. Psychopharmacology 20040901
Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401
A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030401
Properties