Home Other Building Blocks 6-methylpurine 2'-deoxyriboside

6-methylpurine 2'-deoxyriboside

CAS No.:
16006-64-7
Catalog Number:
AG00ACGL
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00ACGL
Chemical Name:
6-methylpurine 2'-deoxyriboside
CAS Number:
16006-64-7
MDL Number:
MFCD29059892
IUPAC Name:
(2R,3S,5R)-2-(hydroxymethyl)-5-(6-methylpurin-9-yl)oxolan-3-ol
InChI:
InChI=1S/C11H14N4O3/c1-6-10-11(13-4-12-6)15(5-14-10)9-2-7(17)8(3-16)18-9/h4-5,7-9,16-17H,2-3H2,1H3/t7-,8+,9+/m0/s1
InChI Key:
SJXRKKYXNZWKDB-DJLDLDEBSA-N
Properties
Complexity:
306  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
250.107g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
250.258g/mol
Monoisotopic Mass:
250.107g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
93.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.2  
Literature
Title Journal
Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides. European journal of medicinal chemistry 20120101
Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase. Cancer gene therapy 20110601
Enzymatic synthesis of 2'-deoxyadenosine and 6-methylpurine-2'-deoxyriboside by Escherichia coli DH5alpha overexpressing nucleoside phosphorylases from Escherichia coli BL21. Journal of bioscience and bioengineering 20100801
Synergistic antitumor efficacy of suicide/ePNP gene and 6-methylpurine 2'-deoxyriboside via Salmonella against murine tumors. Cancer gene therapy 20080701
hTERT-targeted E. coli purine nucleoside phosphorylase gene/6-methylpurine deoxyribose therapy for pancreatic cancer. Chinese medical journal 20070805
[Killing effect of PNP/MeP-dR suicide gene system driven by an AFP promoter AF0.3 on AFP-positive hepatoma cells]. Ai zheng = Aizheng = Chinese journal of cancer 20061101
Transcriptional tumor-selective promoter targeting of E. coli purine nucleoside phosphorylase for pancreatic cancer suicide gene therapy. The journal of gene medicine 20050501
Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy. Human gene therapy 20050301
PNP anticancer gene therapy. Current topics in medicinal chemistry 20050101
Suicide gene/prodrug therapy for pancreatic adenocarcinoma by E. coli purine nucleoside phosphorylase and 6-methylpurine 2'-deoxyriboside. Pancreas 20040301
A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration. The Journal of pharmacology and experimental therapeutics 20030301
Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer gene therapy 20030101
Current progress in suicide gene therapy for cancer. World journal of surgery 20020701
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