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Fosfluconazole

CAS No.:
194798-83-9
Catalog Number:
AG00ABTV
Molecular Formula:
C13H13F2N6O4P
Molecular Weight:
386.2507
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$140
- +
25mg
99%
1 week
United States
$223
- +
50mg
99%
1 week
United States
$307
- +
100mg
99%
1 week
United States
$457
- +
Product Description
Catalog Number:
AG00ABTV
Chemical Name:
Fosfluconazole
CAS Number:
194798-83-9
Molecular Formula:
C13H13F2N6O4P
Molecular Weight:
386.2507
MDL Number:
MFCD28978011
IUPAC Name:
[2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-yl] dihydrogen phosphate
InChI:
InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)
InChI Key:
GHJWNRRCRIGGIO-UHFFFAOYSA-N
SMILES:
Fc1ccc(c(c1)F)C(OP(=O)(O)O)(Cn1cncn1)Cn1cncn1
UNII:
3JIJ299EWH
Properties
Complexity:
511  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
386.07g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
386.256g/mol
Monoisotopic Mass:
386.07g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
128A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.6  
Literature
Title Journal
Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients. Journal of clinical pharmacy and therapeutics 20120601
Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report. Journal of medical case reports 20110101
Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report. Infection 20091201
[Comparison of micafungin and fosfluconazole as prophylaxis for invasive fungal infection during neutropenia in children undergoing chemotherapy and hematopoietic stem cell transplantation]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20091201
[Case of basilar artery occlusion caused by mucormycotic embolism in the course of myelodysplastic syndrome]. Brain and nerve = Shinkei kenkyu no shinpo 20090901
Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug metabolism and disposition: the biological fate of chemicals 20090701
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Fosfluconazole for antifungal prophylaxis in very low birth weight infants. International journal of pediatrics 20090101
[Clinical efficacies of antifungal injections]. Nihon rinsho. Japanese journal of clinical medicine 20081201
[Hypercalcemia associated with all-trans retinoic acid therapy for microgranular type acute promyelocytic leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20080601
[Improved outcome in brain abscess during induction in acute myelocytic leukemia]. Gan to kagaku ryoho. Cancer & chemotherapy 20070501
Elevation of activated platelet-dependent chemokines and soluble cell adhesion molecules in patients with hematologic malignancies and high levels of beta-D-glucan. Pathophysiology of haemostasis and thrombosis 20070101
Infectious myositis involving the piriformis in a patient with rheumatoid arthritis. Modern rheumatology 20060101
Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug metabolism and pharmacokinetics 20051201
The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. British journal of clinical pharmacology 20050201
[A case of cryptococcal meningitis presenting initially as bilateral hearing loss]. No to shinkei = Brain and nerve 20041001
Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers. British journal of clinical pharmacology 20040701
[Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040701
Comparison of the pharmacokinetics of fosfluconazole and fluconazole after single intravenous administration of fosfluconazole in healthy Japanese and Caucasian volunteers. European journal of clinical pharmacology 20040601
The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. British journal of clinical pharmacology 20040601
Pharmacokinetics and safety of Fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers. Journal of clinical pharmacology 20040301
Properties