Name: Name:GNE-3511
Brand: Angene
SKU: AG00ABS6
Rating: 90 (10 reviews)

GNE-3511

CAS No.:

1496581-76-0

Catalog Number:

AG00ABS6

Molecular Formula:

C23H26F2N6O

Molecular Weight:

440.4889

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

1mg

≥98%

1 week

United States

$104

- +

5mg

≥98%

1 week

United States

$222

- +

10mg

≥98%

1 week

United States

$293

- +

25mg

≥98%

1 week

United States

$589

- +

50mg

99%

1 week

United States

$957

- +

100mg

99%

1 week

United States

$1623

- +

200mg

99%

1 week

United States

$2723

- +

Product Description

Catalog Number:

AG00ABS6

Chemical Name:

GNE-3511

CAS Number:

1496581-76-0

Molecular Formula:

C23H26F2N6O

Molecular Weight:

440.4889

MDL Number:

MFCD28502215

IUPAC Name:

2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile

InChI:

InChI=1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2,(H,27,28,29)

InChI Key:

RHFIAUKMKYHHFA-UHFFFAOYSA-N

SMILES:

N#Cc1ccnc(c1)Nc1cc(cc(n1)N1CCC(C1)(F)F)C1CCN(CC1)C1COC1

Properties

Complexity:

689

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

440.214g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

440.499g/mol

Monoisotopic Mass:

440.214g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

77.3A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

3.2

Literature

Title	Journal
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).	Journal of medicinal chemistry 20151022
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.	Journal of medicinal chemistry 20150108
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.	Journal of medicinal chemistry 20070111