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Bms-191095

CAS No.:
166095-21-2
Catalog Number:
AG00ABR5
Molecular Formula:
C22H21ClN4O2
Molecular Weight:
408.8807
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%
1 week
United States
$307
- +
5mg
98%
1 week
United States
$640
- +
10mg
98%
1 week
United States
$890
- +
25mg
98%
1 week
United States
$1723
- +
50mg
98%
1 week
United States
$2723
- +
Product Description
Catalog Number:
AG00ABR5
Chemical Name:
Bms-191095
CAS Number:
166095-21-2
Molecular Formula:
C22H21ClN4O2
Molecular Weight:
408.8807
MDL Number:
MFCD25977742
IUPAC Name:
(3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile
InChI:
InChI=1S/C22H21ClN4O2/c1-22(2)21(28)20(17-11-14(12-24)3-8-18(17)29-22)27(13-19-25-9-10-26-19)16-6-4-15(23)5-7-16/h3-11,20-21,28H,13H2,1-2H3,(H,25,26)/t20-,21+/m0/s1
InChI Key:
SMIKIPXIDLITMP-LEWJYISDSA-N
SMILES:
N#Cc1ccc2c(c1)[C@H](N(c1ccc(cc1)Cl)Cc1ncc[nH]1)[C@H](C(O2)(C)C)O
UNII:
K6V527OYN8
Properties
Complexity:
615  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
408.135g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
408.886g/mol
Monoisotopic Mass:
408.135g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
85.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3  
Literature
Title Journal
The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080601
GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. Basic research in cardiology 20070701
Chronic preconditioning: a novel approach for cardiac protection. American journal of physiology. Heart and circulatory physiology 20070501
The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070201
Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. American journal of physiology. Heart and circulatory physiology 20060601
Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria. Brain research bulletin 20050730
Mitochondrial KATP channels in hindlimb remote ischemic preconditioning of skeletal muscle against infarction. American journal of physiology. Heart and circulatory physiology 20050201
BMS-191095, a cardioselective mitochondrial K(ATP) opener, inhibits human platelet aggregation by opening mitochondrial K(ATP) channels. Archives of pharmacal research 20050101
Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. Journal of medicinal chemistry 20040226
The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning. Neuroreport 20040209
In vivo characterization of the mitochondrial selective K(ATP) opener (3R)-trans-4-((4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril monohydrochloride (BMS-191095): cardioprotective, hemodynamic, and electrophysiological effects. The Journal of pharmacology and experimental therapeutics 20021001
Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Cardiovascular research 20020815
Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia. Cardiovascular drug reviews 20020101
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. The Journal of pharmacology and experimental therapeutics 20010601
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. Journal of medicinal chemistry 20010524
Properties