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SB242235

CAS No.:
193746-75-7
Catalog Number:
AG00ABLM
Molecular Formula:
C19H20FN5O
Molecular Weight:
353.3934
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$307
- +
10mg
98%
1 week
United States
$457
- +
50mg
98%
1 week
United States
$1307
- +
100mg
98%
1 week
United States
$2057
- +
Product Description
Catalog Number:
AG00ABLM
Chemical Name:
SB242235
CAS Number:
193746-75-7
Molecular Formula:
C19H20FN5O
Molecular Weight:
353.3934
MDL Number:
MFCD08690575
IUPAC Name:
4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine
InChI:
InChI=1S/C19H20FN5O/c1-26-19-22-11-8-16(24-19)18-17(13-2-4-14(20)5-3-13)23-12-25(18)15-6-9-21-10-7-15/h2-5,8,11-12,15,21H,6-7,9-10H2,1H3
InChI Key:
PDTYLGXVBIWRIM-UHFFFAOYSA-N
SMILES:
COc1nccc(n1)c1n(cnc1c1ccc(cc1)F)C1CCNCC1
Properties
Complexity:
442  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
353.165g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
353.401g/mol
Monoisotopic Mass:
353.165g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
64.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1  
Literature
Title Journal
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorganic & medicinal chemistry letters 20080801
Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function. British journal of pharmacology 20061201
Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. The Journal of investigative dermatology 20050601
Benzimidazolone p38 inhibitors. Bioorganic & medicinal chemistry letters 20040223
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Molecular pharmacology 20020701
Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. Bioorganic & medicinal chemistry letters 20011105
Properties