(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE
| Title | Journal |
|---|---|
| Effect of oestrogen receptors on brain NMDA receptors of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. | Journal of neuroendocrinology 20121101 |
| Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. | Neuropharmacology 20121101 |
| Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory. | Learning & memory (Cold Spring Harbor, N.Y.) 20120914 |
| NMDARs mediate the role of monoamine oxidase A in pathological aggression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120620 |
| NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury. | Neurobiology of disease 20120601 |
| Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia. | European journal of pharmacology 20120515 |
| Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy. | Epilepsia 20120501 |
| Reduction of inflammatory pain in female rats after NR2B NMDA cortical antagonism. | Psicothema 20120501 |
| Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models. | Pain 20120501 |
| Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons. | Naunyn-Schmiedeberg's archives of pharmacology 20120201 |
| Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain. | Brain research 20120111 |
| Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats. | Molecular pain 20120101 |
| Genetic, pharmacological and lesion analyses reveal a selective role for corticohippocampal GLUN2B in a novel repeated swim stress paradigm. | Neuroscience 20111013 |
| Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain. | Brain, behavior, and immunity 20111001 |
| Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill. | Behavioral neuroscience 20111001 |
| Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831 |
| Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning. | Psychopharmacology 20110801 |
| Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro. | The Chinese journal of physiology 20110630 |
| Peripheral administration of NR2 antagonists attenuates orofacial formalin-induced nociceptive behavior in rats. | Progress in neuro-psychopharmacology & biological psychiatry 20110601 |
| A silent synapse-based mechanism for cocaine-induced locomotor sensitization. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110601 |
| Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens. | Neuropharmacology 20110501 |
| Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. | Neuropharmacology 20110501 |
| NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid. | Neurological research 20110501 |
| Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. | Biological psychiatry 20110415 |
| The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice. | Psychopharmacology 20110401 |
| NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine. | Behavioural pharmacology 20110401 |
| Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels. | Neuroscience 20110317 |
| Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation. | Biological psychiatry 20110201 |
| [Effects of the neurogenesis stimulator Ro 25-6981 upon formation of spatial skill in adult rats depend on the term of its administration and the animals' ability to learn]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110201 |
| An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine. | Psychopharmacology 20110101 |
| Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. | Molecular pain 20110101 |
| Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root. | Molecular pain 20110101 |
| Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. | Experimental neurology 20101001 |
| Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach. | Bioorganic & medicinal chemistry letters 20100915 |
| mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. | Science (New York, N.Y.) 20100820 |
| Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728 |
| Inverse relationship between seizure expression and extrasynaptic NMDAR function following chronic NMDAR inhibition. | Epilepsia 20100701 |
| Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. | Journal of neurophysiology 20100601 |
| Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. | Experimental neurology 20100401 |
| Effects of agents targeting glutamatergic systems on marble-burying behavior. | Neuroscience letters 20100303 |
| NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100301 |
| Effects of acute stress and GluN2B-containing NMDA receptor antagonism on object and object-place recognition memory. | Neurobiology of learning and memory 20100201 |
| Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats. | Journal of orofacial pain 20100101 |
| Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release. | Brain research 20091027 |
| NR2A-containing NMDA receptors are required for L-LTP induction and depotentiation in CA1 region of hippocampal slices. | The European journal of neuroscience 20090601 |
| A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury. | Journal of neurotrauma 20090501 |
| Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons. | The Journal of biological chemistry 20090320 |
| Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus. | Neuroscience 20090303 |
| Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists. | Bioorganic & medicinal chemistry 20090215 |
| Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. | Experimental neurology 20090201 |
| Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing. | Pharmacology, biochemistry, and behavior 20090101 |
| A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory pain. | Molecular pain 20090101 |
| D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. | Neuropharmacology 20081001 |
| Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism. | Journal of neurochemistry 20080701 |
| Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum. | Journal of neurochemistry 20080701 |
| D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401 |
| Spinal cord long-term potentiation is attenuated by the NMDA-2B receptor antagonist Ro 25-6981. | Acta physiologica (Oxford, England) 20080301 |
| Tonic facilitation of glutamate release by glycine binding sites on presynaptic NR2B-containing NMDA autoreceptors in the rat visual cortex. | Neuroscience letters 20080227 |
| Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors. | European journal of pharmacology 20080226 |
| Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway. | Neuroscience 20080124 |
| Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. | The Journal of pharmacology and experimental therapeutics 20070501 |
| Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides. | Journal of medicinal chemistry 20070308 |
| Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats. | The European journal of neuroscience 20070201 |
| Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. | Neuropharmacology 20070101 |
| Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. | Neuropharmacology 20070101 |
| NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia. | Epilepsy research 20061201 |
| N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus. | Neuroscience 20060901 |
| Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20060901 |
| NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo. | Neuroreport 20060821 |
| Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060816 |
| An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models. | European journal of pain (London, England) 20060801 |
| Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias. | Psychopharmacology 20060401 |
| Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315 |
| Glutamate-based therapeutic approaches: NR2B receptor antagonists. | Current opinion in pharmacology 20060201 |
| Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125 |
| Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111 |
| Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes. | Synapse (New York, N.Y.) 20060101 |
| Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo. | Hippocampus 20060101 |
| Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. | Hippocampus 20060101 |
| Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. | Neuron 20050915 |
| Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice. | Synapse (New York, N.Y.) 20050615 |
| Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices. | Experimental brain research 20050401 |
| BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. | Synapse (New York, N.Y.) 20050101 |
| The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus accumbens. | The Journal of pharmacology and experimental therapeutics 20041101 |
| Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908 |
| Oxamides as novel NR2B selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20040802 |
| Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. | Pain 20040601 |
| Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. | Science (New York, N.Y.) 20040514 |
| Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. | Experimental neurology 20040501 |
| The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. | Current medicinal chemistry 20040201 |
| Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20031103 |
| Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry. | Science (New York, N.Y.) 20030509 |
| Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. | Behavioural pharmacology 20030501 |
| 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20030310 |
| Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20030224 |
| The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant. | European journal of pharmacology 20030101 |
| Blockade of NMDA receptor subtype NR2B prevents seizures but not apoptosis of dentate gyrus neurons in bacterial meningitis in infant rats. | BMC neuroscience 20030101 |
| Role of NR2B-containing N-methyl-D-aspartate receptors in haloperidol-induced c-Fos expression in the striatum and nucleus accumbens. | Neuroscience 20030101 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist. | Bioorganic & medicinal chemistry letters 20010820 |
| Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010801 |
| NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent. | Behavioural pharmacology 20010401 |
| Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. | European journal of pharmacology 20010330 |