Home Other Building Blocks Ranirestat

Ranirestat

CAS No.:
147254-64-6
Catalog Number:
AG00ABLJ
Molecular Formula:
C17H11BrFN3O4
Molecular Weight:
420.1893
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$490
- +
10mg
98%
1 week
United States
$807
- +
50mg
98%
1 week
United States
$2057
- +
100mg
98%
1 week
United States
$3390
- +
Product Description
Catalog Number:
AG00ABLJ
Chemical Name:
Ranirestat
CAS Number:
147254-64-6
Molecular Formula:
C17H11BrFN3O4
Molecular Weight:
420.1893
MDL Number:
MFCD00920915
IUPAC Name:
(3R)-2'-[(4-bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5-tetrone
InChI:
InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
InChI Key:
QCVNMNYRNIMDKV-QGZVFWFLSA-N
SMILES:
O=C1NC(=O)[C@]2(C1)C(=O)N(Cc1ccc(cc1F)Br)C(=O)c1n2ccc1
UNII:
Z26P56GFTV
Properties
Complexity:
689  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
418.992g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
420.194g/mol
Monoisotopic Mass:
418.992g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
88.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3  
Literature
Title Journal
A concise enantioselective synthesis of (-)-ranirestat. Organic letters 20100319
Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. Journal of diabetes and its complications 20100101
Inventing and understanding catalytic, enantioselective reactions. Current opinion in drug discovery & development 20091101
Ranirestat for the management of diabetic sensorimotor polyneuropathy. Diabetes care 20090701
Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. Journal of pharmacological sciences 20090201
An improved lanthanum catalyst system for asymmetric amination: toward a practical asymmetric synthesis of AS-3201 (Ranirestat). Organic letters 20080703
Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats. Journal of pharmacological sciences 20080701
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats. Journal of pharmacological sciences 20080701
Stability and hydrolysis kinetics of spirosuccinimide type inhibitors of aldose reductase in aqueous solution and retardation of their hydrolysis by the target enzyme. Journal of pharmaceutical sciences 20080401
Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications. Expert opinion on investigational drugs 20080401
Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochemical pharmacology 20060112
Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy. Diabetes care 20060101
[Role of polyol pathway in pathogenesis of diabetic microangiopathy]. Nihon rinsho. Japanese journal of clinical medicine 20050601
[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor]. Nihon rinsho. Japanese journal of clinical medicine 20050601
Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy. Diabetes care 20041001
Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes. Biochemical pharmacology 20040401
Stereospecific interaction of a novel spirosuccinimide type aldose reductase inhibitor, AS-3201, with aldose reductase. Biochemistry 20010727
Properties