Pafuramidine
| Title | Journal |
|---|---|
| Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. | Bioorganic & medicinal chemistry 20131101 |
| A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. | Toxicological sciences : an official journal of the Society of Toxicology 20121201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. | The Journal of pharmacology and experimental therapeutics 20110501 |
| Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo. | PloS one 20110101 |
| Diamidines for human African trypanosomiasis. | Current opinion in investigational drugs (London, England : 2000) 20100801 |
| Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. | Bioorganic & medicinal chemistry 20100515 |
| Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. | Journal of medicinal chemistry 20100114 |
| Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. | Journal of clinical laboratory analysis 20100101 |
| Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites. | The American journal of tropical medicine and hygiene 20090401 |
| Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. | Acta tropica 20081001 |
| Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines. | Bioorganic & medicinal chemistry 20080115 |
| Carbamate prodrugs of N-alkylfuramidines. | European journal of medicinal chemistry 20080101 |
| Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. | Expert review of anti-infective therapy 20071201 |
| Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
| Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride). | Drug metabolism and disposition: the biological fate of chemicals 20070601 |
| CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues. | Journal of medicinal chemistry 20060824 |
| Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. | Current opinion in investigational drugs (London, England : 2000) 20060201 |
| Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. | Drug metabolism and disposition: the biological fate of chemicals 20051201 |
| Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections. | The Journal of infectious diseases 20050715 |
| Treatment and control of human African trypanosomiasis. | Current opinion in infectious diseases 20041201 |
| O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection. | Journal of medicinal chemistry 20040812 |
| Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents. | Journal of medicinal chemistry 20040701 |
| Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. | Acta tropica 20040701 |
| Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry. | Journal of mass spectrometry : JMS 20040401 |
| DB-289 Immtech International. | IDrugs : the investigational drugs journal 20031101 |
| New oral drug for PCP. | AIDS patient care and STDs 20031101 |
| Synthesis and antiprotozoal activity of aza-analogues of furamidine. | Journal of medicinal chemistry 20031023 |
| Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules. | Antimicrobial agents and chemotherapy 20030701 |
| Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. | Pharmaceutical research 20021101 |
| Treatment of human African trypanosomiasis--present situation and needs for research and development. | The Lancet. Infectious diseases 20020701 |
| Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry. | Rapid communications in mass spectrometry : RCM 20020101 |