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eperezolid

CAS No.:
165800-04-4
Catalog Number:
AG00ABJW
Molecular Formula:
C18H23FN4O5
Molecular Weight:
394.3974
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
96%
1 week
United States
$540
- +
10mg
96%
1 week
United States
$890
- +
50mg
96%
1 week
United States
$2557
- +
100mg
96%
1 week
United States
$3557
- +
Product Description
Catalog Number:
AG00ABJW
Chemical Name:
eperezolid
CAS Number:
165800-04-4
Molecular Formula:
C18H23FN4O5
Molecular Weight:
394.3974
MDL Number:
MFCD00941980
IUPAC Name:
N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
InChI:
InChI=1S/C18H23FN4O5/c1-12(25)20-9-14-10-23(18(27)28-14)13-2-3-16(15(19)8-13)21-4-6-22(7-5-21)17(26)11-24/h2-3,8,14,24H,4-7,9-11H2,1H3,(H,20,25)/t14-/m0/s1
InChI Key:
SIMWTRCFFSTNMG-AWEZNQCLSA-N
SMILES:
OCC(=O)N1CCN(CC1)c1ccc(cc1F)N1C[C@@H](OC1=O)CNC(=O)C
UNII:
C460ZSU1OW
Properties
Complexity:
599  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
394.165g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
394.403g/mol
Monoisotopic Mass:
394.165g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
102A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3  
Literature
Title Journal
Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PloS one 20120101
4-(o-Tol-yl)piperazin-1-ium chloride. Acta crystallographica. Section E, Structure reports online 20111101
Production of icaADBC-encoded polysaccharide intercellular adhesin and therapeutic failure in pediatric patients with Staphylococcal device-related infections. BMC infectious diseases 20100101
Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. Journal of inflammation (London, England) 20100101
Clinical outcomes of antimicrobial lock solutions used in a treatment modality: a retrospective case series analysis. Clinical pharmacology : advances and applications 20100101
Synthesis and antibacterial activities of eperezolid analogs with glycinyl substitutions. Archiv der Pharmazie 20090701
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. Journal of medicinal chemistry 20080410
Synthesis and in vitro antibacterial activities of novel oxazolidinones. European journal of medicinal chemistry 20080401
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. Bioorganic & medicinal chemistry letters 20070915
Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701
High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma. Biomedical chromatography : BMC 20060801
Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. Bioorganic & medicinal chemistry letters 20060315
Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. Bioorganic & medicinal chemistry letters 20051001
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. Bioorganic & medicinal chemistry letters 20050602
In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci. Annals of clinical microbiology and antimicrobials 20050101
Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent. Bioorganic & medicinal chemistry 20040901
Simple method for the assay of eperezolid in brain heart infusion broth by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis 20040629
Oxazolidinone: search for highly potent antibacterial. Bioorganic & medicinal chemistry letters 20040621
Simple method for the assay of linezolid in Brain Heart Infusion broth by high-performance liquid chromatography. Biomedical chromatography : BMC 20040101
Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. Journal of medicinal chemistry 20030116
Oxazolidinone antibacterial agents: a critical review. Current topics in medicinal chemistry 20030101
Carbon-carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria. Bioorganic & medicinal chemistry 20011201
The discovery of linezolid, the first oxazolidinone antibacterial agent. Current drug targets. Infectious disorders 20010801
Novel piperidinyloxy oxazolidinone antimicrobial agents. Bioorganic & medicinal chemistry letters 20010723
RU-79115 (Aventis Pharma). Current opinion in investigational drugs (London, England : 2000) 20010601
Oxazolidinones: a review. Drugs 20000101
Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model. Antimicrobial agents and chemotherapy 19990501
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents. Antimicrobial agents and chemotherapy 19960401
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. Journal of medicinal chemistry 19960202
Properties