Name: Name:Az 191
Brand: Angene
SKU: AG00ABIP
Rating: 90 (10 reviews)

Az 191

CAS No.:

1594092-37-1

Catalog Number:

AG00ABIP

Molecular Formula:

C24H27N7O

Molecular Weight:

429.5175

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

1mg

≥98%

1 week

United States

$91

- +

5mg

99%

1 week

United States

$157

- +

10mg

99%

1 week

United States

$207

- +

50mg

99%

1 week

United States

$473

- +

100mg

99%

1 week

United States

$790

- +

Product Description

Catalog Number:

AG00ABIP

Chemical Name:

Az 191

CAS Number:

1594092-37-1

Molecular Formula:

C24H27N7O

Molecular Weight:

429.5175

MDL Number:

MFCD28015098

IUPAC Name:

N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine

InChI:

InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

InChI Key:

ZYVXTMKTGDARKR-UHFFFAOYSA-N

SMILES:

COc1cc(ccc1Nc1nccc(n1)c1cn(c2c1ccnc2)C)N1CCN(CC1)C

Properties

Complexity:

601

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

429.228g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

429.528g/mol

Monoisotopic Mass:

429.228g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

71.3A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

2.7

Literature

Title	Journal
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.	Journal of medicinal chemistry 20150326
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).	The Biochemical journal 20140101

Properties