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AP20187

CAS No.:
195514-80-8
Catalog Number:
AG00ABIM
Molecular Formula:
C82H107N5O20
Molecular Weight:
1482.7485
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$557
- +
5mg
99%
1 week
United States
$1390
- +
10mg
99%
1 week
United States
$2223
- +
25mg
99%
1 week
United States
$3223
- +
50mg
99%
1 week
United States
$4390
- +
Product Description
Catalog Number:
AG00ABIM
Chemical Name:
AP20187
CAS Number:
195514-80-8
Molecular Formula:
C82H107N5O20
Molecular Weight:
1482.7485
MDL Number:
MFCD28167729
IUPAC Name:
[(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[[2-[[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]methyl]-3-(dimethylamino)propyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
InChI:
InChI=1S/C82H107N5O20/c1-15-61(57-43-71(98-9)77(102-13)72(44-57)99-10)79(90)86-37-19-17-27-63(86)81(92)106-65(33-29-52-31-35-67(94-5)69(39-52)96-7)55-23-21-25-59(41-55)104-50-75(88)83-47-54(49-85(3)4)48-84-76(89)51-105-60-26-22-24-56(42-60)66(34-30-53-32-36-68(95-6)70(40-53)97-8)107-82(93)64-28-18-20-38-87(64)80(91)62(16-2)58-45-73(100-11)78(103-14)74(46-58)101-12/h21-26,31-32,35-36,39-46,54,61-66H,15-20,27-30,33-34,37-38,47-51H2,1-14H3,(H,83,88)(H,84,89)/t61-,62-,63-,64-,65+,66+/m0/s1
InChI Key:
NSBGUMKAXUXKGI-BPNHAYRBSA-N
SMILES:
CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@@H](c1cccc(c1)OCC(=O)NCC(CN(C)C)CNC(=O)COc1cccc(c1)[C@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@H](c1cc(OC)c(c(c1)OC)OC)CC)CCc1ccc(c(c1)OC)OC)CCc1ccc(c(c1)OC)OC)c1cc(OC)c(c(c1)OC)OC
Properties
Complexity:
2450  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
1481.751g/mol
Formal Charge:
0
Heavy Atom Count:
107  
Hydrogen Bond Acceptor Count:
21  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
1482.773g/mol
Monoisotopic Mass:
1481.751g/mol
Rotatable Bond Count:
42  
Topological Polar Surface Area:
265A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
12.2  
Literature
Title Journal
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 20111102
Long-term regulation of genetically modified primary hematopoietic cells in dogs. Molecular therapy : the journal of the American Society of Gene Therapy 20110701
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Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer research 20101201
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eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217
Suppression of the intrinsic apoptosis pathway by synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217
Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions. The Journal of biological chemistry 20091106
A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. Journal of neuroscience research 20090901
Chemically inducible inactivation of protein synthesis in genetically targeted neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527
Controlled rod cell ablation in transgenic Xenopus laevis. Investigative ophthalmology & visual science 20090201
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells. Cancer gene therapy 20081001
PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes 20080801
Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl. Blood 20080415
Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model. Lab animal 20080101
Constitutive and AP20187-induced Ret activation in photoreceptors does not protect from light-induced damage. Investigative ophthalmology & visual science 20071101
Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1. Laboratory investigation; a journal of technical methods and pathology 20070801
Aggregation of cellular prion protein is initiated by proximity-induced dimerization. Journal of neurochemistry 20070801
AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice. Human gene therapy 20070201
The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. Journal of cell science 20060801
Development of peritoneal adhesions in macrophage depleted mice. The Journal of surgical research 20060401
Establishment of a cell model based on FKBP12 dimerization for screening of FK506-like neurotrophic small molecular compounds. Journal of biomolecular screening 20060401
Establishment of cell lines that exhibit correct ontogenic stage-specific gene expression profiles from tissues of yeast artificial chromosome transgenic mice using chemically induced growth signals. Methods in molecular biology (Clifton, N.J.) 20060101
Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Molecular endocrinology (Baltimore, Md.) 20051101
Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nature medicine 20050701
Dimer formation of receptor activator of nuclear factor kappaB induces incomplete osteoclast formation. Biochemical and biophysical research communications 20041203
Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors. Human gene therapy 20041101
Differences in F36VMpl-based in vivo selection among large animal models. Molecular therapy : the journal of the American Society of Gene Therapy 20041001
In vivo selection of genetically modified erythroid cells using a jak2-based cell growth switch. Molecular therapy : the journal of the American Society of Gene Therapy 20040901
[Promotion of in vitro long term expansion of primitive multipotential hematopoietic cells by transduced JAK2 gene]. Zhonghua yi xue za zhi 20040602
Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. Journal of leukocyte biology 20040401
[Long term regulated expansion and committed differentiation of JAK2 gene transfected hematopoietic stem/progenitor cells in vitro]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20040201
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. The EMBO journal 20040114
Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. Journal of thrombosis and haemostasis : JTH 20030601
Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3. FEBS letters 20030410
An inducible system for the study of FGF signalling in early amphibian development. Developmental biology 20030401
Activation of procaspases by FK506 binding protein-mediated oligomerization. Science's STKE : signal transduction knowledge environment 20030128
Small-molecule-directed mpl signaling can complement growth factors to selectively expand genetically modified cord blood cells. Stem cells (Dayton, Ohio) 20030101
Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice. Nature biotechnology 20021201
Pharmacologically regulated in vivo selection in a large animal. Blood 20020915
Ablation of microvessels in vivo upon dimerization of iCaspase-9. Gene therapy 20020401
Dimerizer-induced proliferation of genetically modified hepatocytes. Molecular therapy : the journal of the American Society of Gene Therapy 20020401
Properties