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TAPI-2

CAS No.:
187034-31-7
Catalog Number:
AG00ABA1
Molecular Formula:
C19H37N5O5
Molecular Weight:
415.5276
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
1 week
United States
$307
- +
5mg
95%
1 week
United States
$1057
- +
10mg
95%
1 week
United States
$1640
- +
Product Description
Catalog Number:
AG00ABA1
Chemical Name:
TAPI-2
CAS Number:
187034-31-7
Molecular Formula:
C19H37N5O5
Molecular Weight:
415.5276
MDL Number:
MFCD22581509
IUPAC Name:
N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
InChI:
InChI=1S/C19H37N5O5/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25)/t12-,13?,15+/m0/s1
InChI Key:
LMIQCBIEAHJAMZ-RMTCENKZSA-N
SMILES:
NCCNC(=O)C(NC(=O)C(C(C)(C)C)NC(=O)C(CC(=O)NO)CC(C)C)C
Properties
Complexity:
574  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
415.279g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
415.535g/mol
Monoisotopic Mass:
415.279g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
163A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.1  
Literature
Title Journal
Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin. Archives of toxicology 20121201
Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells. Archives of toxicology 20121001
Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion. American journal of physiology. Cell physiology 20100601
Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cellular signalling 20100301
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection. Experimental cell research 20091210
Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909
Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cellular signalling 20090801
Novel approach for formation of platelet-like particles from mouse embryonic stem cells without using feeder cells. The Kurume medical journal 20090101
Regulation of the receptor for TNFalpha, TNFR1, in human conjunctival epithelial cells. Investigative ophthalmology & visual science 20080901
Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Analytical biochemistry 20070715
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness. Cancer science 20070501
Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. Journal of neuroscience research 20060901
Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells. American journal of physiology. Lung cellular and molecular physiology 20050801
Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. The Journal of biological chemistry 20050415
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040101
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. The Journal of biological chemistry 20031114
Tomoregulin ectodomain shedding by proinflammatory cytokines. Life sciences 20030815
Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2. The Journal of biological chemistry 20021011
Properties