6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
| Title | Journal |
|---|---|
| Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. | Archives of toxicology 20180901 |
| Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. | Chemical research in toxicology 20150615 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. | The Journal of biological chemistry 20130322 |
| Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors. | Molecular pharmacology 20121001 |
| The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice. | Cancer prevention research (Philadelphia, Pa.) 20121001 |
| Tributyltin synergizes with 20-hydroxyecdysone to produce endocrine toxicity. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells. | Molecular endocrinology (Baltimore, Md.) 20101101 |
| Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. | Cancer prevention research (Philadelphia, Pa.) 20101101 |
| Retinoic acid regulates myelin formation in the peripheral nervous system. | Glia 20100901 |
| Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice. | Cancer prevention research (Philadelphia, Pa.) 20091201 |
| Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. | General and comparative endocrinology 20090915 |
| Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells. | Fertility and sterility 20090501 |
| Rexinoids modulate steroid and xenobiotic receptor activity by increasing its protein turnover in a calpain-dependent manner. | The Journal of biological chemistry 20080808 |
| Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080715 |
| The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis. | Molecular cancer therapeutics 20080501 |
| Development and quality of bovine morulae cultured in serum-free medium with specific retinoid receptor agonists. | Reproduction, fertility, and development 20080101 |
| PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL. | Cancer biology & therapy 20071201 |
| Retinoid receptor-specific agonists regulate bovine in vitro early embryonic development, differentiation and expression of genes related to cell cycle arrest and apoptosis. | Theriogenology 20071101 |
| In silico prediction of pregnane X receptor activators by machine learning approaches. | Molecular pharmacology 20070101 |
| Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. | Cancer research 20061215 |
| The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061001 |
| Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. | Cancer research 20060701 |
| PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. | Journal of lipid research 20060501 |
| Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta. | Biochemical pharmacology 20060428 |
| Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade. | Breast cancer research and treatment 20060301 |
| Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. | Cancer research 20051215 |
| Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors. | The Journal of biological chemistry 20051118 |
| Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. | Molecular endocrinology (Baltimore, Md.) 20051001 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. | Endocrinology 20050801 |
| Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. | Diabetologia 20050301 |
| Activation of peroxisome proliferator-activated receptor-gamma and retinoid X receptor inhibits aromatase transcription via nuclear factor-kappaB. | Endocrinology 20050101 |
| Rexinoids may be ready for prime time in prevention, but challenges remain. | Journal of the National Cancer Institute 20041215 |
| Molecular cloning and characterization of two novel human RXR alpha splice variants. | The Journal of steroid biochemistry and molecular biology 20040901 |
| Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos. | Proceedings of the National Academy of Sciences of the United States of America 20040615 |
| The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. | Cancer research 20040515 |
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. | Bioorganic & medicinal chemistry letters 20040322 |
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. | Bioorganic & medicinal chemistry letters 20031117 |
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. | Journal of medicinal chemistry 20030911 |
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. | Journal of medicinal chemistry 20030619 |
| Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. | The Journal of biological chemistry 20030321 |
| Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021001 |
| Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. | Endocrinology 20020801 |
| Redundant pathways for negative feedback regulation of bile acid production. | Developmental cell 20020601 |
| The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. | The Journal of biological chemistry 20020329 |
| Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists. | Diabetes 20020301 |
| PPARgamma is not a critical mediator of primary monocyte differentiation or foam cell formation. | Biochemical and biophysical research communications 20020118 |
| Regulation of aromatase by nuclear receptors. | The Journal of steroid biochemistry and molecular biology 20011201 |
| Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. | The Journal of clinical investigation 20011001 |
| The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. | Molecular endocrinology (Baltimore, Md.) 20010801 |
| Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells. | Molecular and cellular endocrinology 20010705 |
| Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. | Molecular pharmacology 20010401 |
| Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle. | Diabetologia 20010401 |
| Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity. | Molecular pharmacology 20010201 |
| Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). | Gene 20010110 |
| The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. | Metabolism: clinical and experimental 20001201 |
| A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. | Molecular endocrinology (Baltimore, Md.) 20001001 |
| Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells. | Biochemical and biophysical research communications 20000519 |
| Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target. | The Journal of biological chemistry 20000428 |
| The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. | Molecular endocrinology (Baltimore, Md.) 20000101 |
| Therapeutic applications for ligands of retinoid receptors. | Current pharmaceutical design 20000101 |
| Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids. | International journal of oncology 19991101 |
| Activation of specific RXR heterodimers by an antagonist of RXR homodimers. | Nature 19961003 |
| Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor. | Molecular and cellular biology 19960701 |
| Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. | Journal of medicinal chemistry 19940204 |