(melle-4)cyclosporin
| Title | Journal |
|---|---|
| Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. | Journal of medicinal chemistry 20141023 |
| In vitro effects of cyclosporine A and tacrolimus on regulatory T-cell proliferation and function. | Transplantation 20120727 |
| Efficacy and mechanism of hypoxic postconditioning in salvage of ex vivo human rectus abdominis muscle from hypoxia/reoxygenation injury. | European journal of pharmacology 20120705 |
| Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. | Journal of molecular and cellular cardiology 20120501 |
| Ischemic postconditioning protects liver from ischemia-reperfusion injury by modulating mitochondrial permeability transition. | Transplantation 20120215 |
| Administration of naked plasmid encoding hepatic stimulator substance by hydrodynamic tail vein injection protects mice from hepatic failure by suppressing the mitochondrial permeability transition. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110701 |
| Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy. | Antiviral research 20110301 |
| N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. | Journal of gastroenterology and hepatology 20110301 |
| NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. | Transplantation 20110227 |
| Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study. | European heart journal 20110101 |
| Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. | Virology journal 20110101 |
| Cyclosporine A inhibits in vitro replication of betaretrovirus associated with primary biliary cirrhosis. | Liver international : official journal of the International Association for the Study of the Liver 20100701 |
| Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. | Autophagy 20091101 |
| NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. | The Journal of pharmacology and experimental therapeutics 20081201 |
| Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism. | American journal of physiology. Regulatory, integrative and comparative physiology 20080801 |
| Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. | Antimicrobial agents and chemotherapy 20080401 |
| Increased mitochondrial calcium coexists with decreased reperfusion injury in postconditioned (but not preconditioned) hearts. | American journal of physiology. Heart and circulatory physiology 20080101 |
| Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog. | Experimental neurology 20080101 |
| Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. | Hepatology (Baltimore, Md.) 20080101 |
| NIM811, a nonimmunosuppressive cyclosporine analogue, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. | Liver international : official journal of the International Association for the Study of the Liver 20071101 |
| Post-treatment with the cyclosporin derivative, NIM811, reduced indices of cell death and increased the volume of spared tissue in the acute period following spinal cord contusion. | Journal of neurotrauma 20071001 |
| NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070501 |
| Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition. | Journal of neurotrauma 20070501 |
| Pretreatment with the cyclosporin derivative, NIM811, improves the function of synaptic mitochondria following spinal cord contusion in rats. | Journal of neurotrauma 20070401 |
| Determination of N-methyl-4-isoleucine-cyclosporin (NIM811) in human whole blood by high performance liquid chromatography-tandem mass spectrometry. | Biomedical chromatography : BMC 20070301 |
| In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin. | Microbiology and immunology 20070101 |
| Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy. | Reviews in medical virology 20070101 |
| Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811. | Biochemical and biophysical research communications 20060512 |
| Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. | Journal of molecular and cellular cardiology 20050201 |
| Postconditioning inhibits mitochondrial permeability transition. | Circulation 20050118 |
| Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. | Hepatology (Baltimore, Md.) 20041101 |
| Mitochondrial permeability transition in cardiomyocyte apoptosis during acute graft rejection. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040701 |
| Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. | Bioorganic & medicinal chemistry letters 20031215 |
| Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001 |
| Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. | Molecular pharmacology 20020701 |
| The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells. | The Journal of general virology 19970401 |
| The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811. | Journal of virology 19960901 |
| Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. | Virology 19960801 |
| Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions. | Journal of virology 19950401 |
| Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication. | Journal of virology 19950201 |
| Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | Antimicrobial agents and chemotherapy 19940801 |