Name: Name:CCT 244747
Brand: Angene
SKU: AG009CM7
Rating: 90 (10 reviews)

CCT 244747

CAS No.:

1404095-34-6

Catalog Number:

AG009CM7

Molecular Formula:

C20H24N8O2

Molecular Weight:

408.4570

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

1mg

≥98%

1 week

United States

$135

- +

2mg

99%

1 week

United States

$207

- +

5mg

≥98%

1 week

United States

$290

- +

10mg

≥98%

1 week

United States

$446

- +

25mg

99%

1 week

United States

$807

- +

50mg

99%

1 week

United States

$1307

- +

Product Description

Catalog Number:

AG009CM7

Chemical Name:

CCT 244747

CAS Number:

1404095-34-6

Molecular Formula:

C20H24N8O2

Molecular Weight:

408.4570

MDL Number:

MFCD25977017

IUPAC Name:

3-[(2R)-1-(dimethylamino)propan-2-yl]oxy-5-[[4-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

InChI:

InChI=1S/C20H24N8O2/c1-13(11-27(2)3)30-20-16(7-21)22-10-19(26-20)25-18-6-17(29-5)15(9-23-18)14-8-24-28(4)12-14/h6,8-10,12-13H,11H2,1-5H3,(H,23,25,26)/t13-/m1/s1

InChI Key:

IENLGMOXAQMNEH-CYBMUJFWSA-N

SMILES:

N#Cc1ncc(nc1OC(CN(C)C)C)Nc1ncc(c(c1)OC)c1cnn(c1)C

Properties

Complexity:

584

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

408.202g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

408.466g/mol

Monoisotopic Mass:

408.202g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

114A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

1.7

Literature

Title	Journal
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.	Journal of medicinal chemistry 20121126
CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.	Clinical cancer research : an official journal of the American Association for Cancer Research 20121015