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ARQ 092 Free Base

CAS No.:
1313881-70-7
Catalog Number:
AG009CLY
Molecular Formula:
C27H24N6
Molecular Weight:
432.5197
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$105
- +
5mg
≥98%
1 week
United States
$251
- +
10mg
99%
1 week
United States
$407
- +
25mg
≥98%
1 week
United States
$847
- +
50mg
99%
1 week
United States
$1573
- +
100mg
99%
1 week
United States
$2890
- +
Product Description
Catalog Number:
AG009CLY
Chemical Name:
ARQ 092 Free Base
CAS Number:
1313881-70-7
Molecular Formula:
C27H24N6
Molecular Weight:
432.5197
MDL Number:
MFCD30187510
IUPAC Name:
3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
InChI:
InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
InChI Key:
HNFMVVHMKGFCMB-UHFFFAOYSA-N
SMILES:
Nc1ncccc1c1nc2c(n1c1ccc(cc1)C1(N)CCC1)nc(cc2)c1ccccc1
UNII:
T1DQI1B52Y
Properties
Complexity:
653  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
432.206g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
432.531g/mol
Monoisotopic Mass:
432.206g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
95.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8  
Literature
Title Journal
Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. Journal of medicinal chemistry 20160714
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PloS one 20150101
Repression of AKT signaling by ARQ 092 in cells and tissues from patients with Proteus syndrome. Scientific reports 20150101
Schizophrenic inability to disattend from strong aspects of meaning. Journal of abnormal psychology 19760201
Properties