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Ns-018

CAS No.:
1239358-86-1
Catalog Number:
AG009CL2
Molecular Formula:
C21H20FN7
Molecular Weight:
389.4288
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$453
- +
10mg
99%
1 week
United States
$605
- +
25mg
99%
1 week
United States
$862
- +
50mg
99%
1 week
United States
$1265
- +
100mg
99%
1 week
United States
$1793
- +
Product Description
Catalog Number:
AG009CL2
Chemical Name:
Ns-018
CAS Number:
1239358-86-1
Molecular Formula:
C21H20FN7
Molecular Weight:
389.4288
MDL Number:
MFCD28502056
IUPAC Name:
6-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine
InChI:
InChI=1S/C21H20FN7/c1-14(15-3-5-18(22)6-4-15)26-19-9-16(17-11-25-29(2)13-17)10-20(27-19)28-21-12-23-7-8-24-21/h3-14H,1-2H3,(H2,24,26,27,28)/t14-/m0/s1
InChI Key:
UQTPDWDAYHAZNT-AWEZNQCLSA-N
SMILES:
Fc1ccc(cc1)C(Nc1nc(Nc2cnccn2)cc(c1)c1cnn(c1)C)C
UNII:
56R994WX4L
Properties
Complexity:
501  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
389.176g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
389.438g/mol
Monoisotopic Mass:
389.176g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
80.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
A phase I, open-label, dose-escalation, multicenter study of the JAK2 inhibitor NS-018 in patients with myelofibrosis. Leukemia 20170201
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis. Blood cancer journal 20140101
Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms. Blood cancer journal 20110701
Properties