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L-701324

CAS No.:
142326-59-8
Catalog Number:
AG009CIR
Molecular Formula:
C21H14ClNO3
Molecular Weight:
363.7938
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$240
- +
50mg
99%
1 week
United States
$640
- +
Product Description
Catalog Number:
AG009CIR
Chemical Name:
L-701324
CAS Number:
142326-59-8
Molecular Formula:
C21H14ClNO3
Molecular Weight:
363.7938
MDL Number:
MFCD00910917
IUPAC Name:
7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
InChI:
InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
InChI Key:
FLVRDMUHUXVRET-UHFFFAOYSA-N
SMILES:
Clc1ccc2c(c1)[nH]c(=O)c(c2O)c1cccc(c1)Oc1ccccc1
UNII:
I9WY146163
Properties
Complexity:
558  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
363.066g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
363.797g/mol
Monoisotopic Mass:
363.066g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
58.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.5  
Literature
Title Journal
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine. Psychopharmacology 20110101
Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological reports : PR 20110101
Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D-aspartate receptors. Neuroscience 20090123
Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. Psychopharmacology 20081001
Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology 20081001
Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor. Pediatric research 20080901
Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801. Psychopharmacology 20080601
NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice. Pharmacological reports : PR 20080101
NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Pharmacology, biochemistry, and behavior 20071201
Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick test of rats. European journal of pharmacology 20070622
Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test. Pharmacological reports : PR 20070101
Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Molecular and cellular neurosciences 20060801
Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. Behavioural pharmacology 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. Journal of medicinal chemistry 20060209
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms. The international journal of neuropsychopharmacology 20050901
Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms. Brain research 20050628
The pharmacological stimulation of NMDA receptors via co-agonist site: an fMRI study in the rat brain. Neuroscience letters 20050501
CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist. Journal of medicinal chemistry 20050224
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain 20040601
Are glycineB sites involved in the development of morphine tolerance? Polish journal of pharmacology 20040101
Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling. The Journal of biological chemistry 20030627
Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites. Journal of receptor and signal transduction research 20020101
Attenuation of morphine dependence and withdrawal by glycine B site antagonists in rats. Pharmacology, biochemistry, and behavior 20010101
NMDA antagonists inhibit the development of ethanol dependence in rats. Polish journal of pharmacology 20010101
L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats. Psychopharmacology 19990401
The role of striatal glutamate receptors in models of Parkinson's disease. Amino acids 19980101
The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents. The Journal of pharmacology and experimental therapeutics 19960501
3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. Journal of medicinal chemistry 19940513
Properties