sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks Unc0321

Unc0321

CAS No.:
1238673-32-9
Catalog Number:
AG009CFD
Molecular Formula:
C27H45N7O3
Molecular Weight:
515.6913
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$218
- +
10mg
98%
1 week
United States
$307
- +
50mg
98%
1 week
United States
$1223
- +
Product Description
Catalog Number:
AG009CFD
Chemical Name:
Unc0321
CAS Number:
1238673-32-9
Molecular Formula:
C27H45N7O3
Molecular Weight:
515.6913
MDL Number:
MFCD18251565
IUPAC Name:
7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
InChI:
InChI=1S/C27H45N7O3/c1-31(2)15-16-36-17-18-37-25-20-23-22(19-24(25)35-5)26(28-21-7-11-33(4)12-8-21)30-27(29-23)34-10-6-9-32(3)13-14-34/h19-21H,6-18H2,1-5H3,(H,28,29,30)
InChI Key:
AULLUGALUBVBDD-UHFFFAOYSA-N
SMILES:
COc1cc2c(cc1OCCOCCN(C)C)nc(nc2NC1CCN(CC1)C)N1CCCN(CC1)C
Properties
Complexity:
652  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
515.358g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
515.703g/mol
Monoisotopic Mass:
515.358g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
78.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9  
Literature
Title Journal
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of medicinal chemistry 20110908
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology 20110710
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of medicinal chemistry 20100812
G9a and Glp methylate lysine 373 in the tumor suppressor p53. The Journal of biological chemistry 20100326
Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PloS one 20080101
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer research 20060401
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes & development 20020715
Properties