Seocalcitol
| Title | Journal |
|---|---|
| Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain. | The Journal of steroid biochemistry and molecular biology 20160401 |
| MNU-induced mammary gland carcinogenesis: chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways. | Toxicology letters 20111110 |
| Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action. | Laboratory investigation; a journal of technical methods and pathology 20110101 |
| Expression and vitamin D3 regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells. | Prostaglandins, leukotrienes, and essential fatty acids 20110101 |
| 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion. | Endocrinology 20100401 |
| Vitamin D3 affects expression of thyroid hormone receptor alpha and deiodinase activity in liver of MNU-treated Sprague-Dawley rats. | General physiology and biophysics 20091201 |
| EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. | Molecular cancer therapeutics 20090701 |
| Characterization of the vitamin D endocrine system in human sebocytes in vitro. | The Journal of steroid biochemistry and molecular biology 20090101 |
| EB1089 induces Skp2-dependent p27 accumulation, leading to cell growth inhibition and cell cycle G1 phase arrest in human hepatoma cells. | Cancer investigation 20090101 |
| Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients. | International journal of cancer 20080915 |
| Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients. | Inflammatory bowel diseases 20080501 |
| The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. | Experimental lung research 20080501 |
| Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. | Molecular cancer therapeutics 20080501 |
| Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators. | Biochimica et biophysica acta 20080201 |
| Inhibition of hepatocellular cancer by EB1089: in vitro and in vive study. | Anticancer research 20080101 |
| Antioxidants and doxorubicin supplementation to modulate CD14 expression and oxidative stress induced by vitamin D3 and seocalcitol in HL60 cells. | Oncology reports 20071201 |
| Vitamin D receptor-dependent inhibition of mammary tumor growth by EB1089 and ultraviolet radiation in vivo. | Endocrinology 20071001 |
| Increased expression of corepressors in aggressive androgen-independent prostate cancer cells results in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness. | Molecular cancer research : MCR 20070901 |
| Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070501 |
| Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells. | Clinical endocrinology 20070301 |
| The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. | Endocrine-related cancer 20070301 |
| Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. | Molecular cell 20070126 |
| In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells. | Cancer biology & therapy 20070101 |
| Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats. | Pharmaceutical research 20061101 |
| Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. | Molecular cancer therapeutics 20061101 |
| Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060601 |
| Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. | Biological chemistry 20060601 |
| Vitamin D receptor is a novel drug target for ovarian cancer treatment. | Current cancer drug targets 20060501 |
| Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE. | Steroids 20060201 |
| Investigation of the mechanisms by which EB1089 abrogates apoptosis induced by 9-cis retinoic acid in pancreatic cancer cells. | Pancreas 20060101 |
| EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer. | Cancer letters 20051118 |
| The role of non-calcemic analogs of vitamin D in differentiation of cultured rat bone marrow into osteoblast-like cells: age and sex differences. | Journal of endocrinological investigation 20051101 |
| Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. | Cell death and differentiation 20051001 |
| 1alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness. | Molecular endocrinology (Baltimore, Md.) 20050901 |
| Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats--effect of medium and long chain triglycerides. | Journal of pharmaceutical sciences 20050801 |
| Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701 |
| Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells. | Apoptosis : an international journal on programmed cell death 20050301 |
| A near-infrared Fourier transform Raman spectroscopy of epidermal keratinocytes: changes in the protein-DNA structure following malignant transformation. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050101 |
| Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050101 |
| Effects of calcitriol, seocalcitol, and medium-chain triglyceride on a canine transitional cell carcinoma cell line. | Anticancer research 20050101 |
| 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue. | Breast cancer research : BCR 20050101 |
| Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089. | The Journal of steroid biochemistry and molecular biology 20041201 |
| [Effects of vitamin D analogue EB1089 on proliferation and apoptosis of hepatic carcinoma cells]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20041101 |
| The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. | Nature medicine 20040901 |
| Modifications of cellular autofluorescence emission spectra under oxidative stress induced by 1 alpha,25dihydroxyvitamin D(3) and its analog EB1089. | Technology in cancer research & treatment 20040801 |
| Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089). | Bone 20040701 |
| Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. | Breast cancer research and treatment 20040501 |
| The tissue-specific distribution of 3H-seocalcitol (EB 1089) and 3H-calcitriol in rats. | The Journal of steroid biochemistry and molecular biology 20040501 |
| Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification. | Journal of medicinal chemistry 20040408 |
| Vitamin D analogs as therapeutic agents: a clinical study update. | Current opinion in investigational drugs (London, England : 2000) 20040301 |
| [Regulatory mechanism of EB1089 for hepatocarcinoma cell proliferation]. | Wei sheng yan jiu = Journal of hygiene research 20040301 |
| Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells. | International journal of cancer 20040120 |
| Molecular analysis of p21 promoter activity isolated from squamous carcinoma cell lines of the head and neck under the influence of 1,25(OH)2 vitamin D3 and its analogs. | Acta oto-laryngologica 20040101 |
| Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. | Biochemical pharmacology 20030801 |
| Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors. | Breast cancer research and treatment 20030801 |
| A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma. | British journal of cancer 20030721 |
| Prostate cancer cell type-specific regulation of the human PTHrP gene via a negative VDRE. | Molecular and cellular endocrinology 20030630 |
| The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030601 |
| The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. | Blood 20030401 |
| Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells. | Endocrinology 20030301 |
| Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. | Molecular and cellular endocrinology 20030227 |
| Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Vitamin D receptor is expressed in pancreatic cancer cells and a vitamin D3 analogue decreases cell number. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20030101 |
| Significant experimental decrease of the hepatocellular carcinoma incidence in C3H/Sy mice after long-term administration of EB1089, a vitamin D analogue. | Oncology research 20030101 |
| [Differential effect of vitamin D analogues on the proliferation of vascular smooth muscle cells]. | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20030101 |
| 1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro. | European journal of immunology 20021201 |
| Vitamin D receptor-dependent antitumour effects of 1,25-dihydroxyvitamin D3 and two synthetic analogues in three in vivo models of prostate cancer. | BJU international 20021001 |
| Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. | The Journal of urology 20021001 |
| Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells. | Brain pathology (Zurich, Switzerland) 20021001 |
| Vector-averaged gravity-induced changes in cell signaling and vitamin D receptor activity in MG-63 cells are reversed by a 1,25-(OH)2D3 analog, EB1089. | Bone 20020901 |
| Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. | The Journal of biological chemistry 20020823 |
| Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. | Molecular endocrinology (Baltimore, Md.) 20020601 |
| The G gamma / T-15 transgenic mouse model of androgen-independent prostate cancer: target cells of carcinogenesis and the effect of the vitamin D analogue EB 1089. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020601 |
| Effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and its analogues (EB1089 and analog V) on canine adenocarcinoma (CAC-8) in nude mice. | Biological & pharmaceutical bulletin 20020501 |
| A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer. | British journal of cancer 20020304 |
| The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells. | International journal of oncology 20020301 |
| Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis. | The American journal of gastroenterology 20020301 |
| Synergistic effect of vitamin D derivatives and retinoids on C2C12 skeletal muscle cells. | IUBMB life 20020301 |
| Sensitive analysis of 1alpha,25-dihydroxyvitamin D3 in biological fluids by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. A 20011123 |
| Autocrine TGFbeta signaling mediates vitamin D3 analog-induced growth inhibition in breast cells. | Journal of cellular physiology 20010901 |
| A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. | Bioorganic & medicinal chemistry 20010901 |
| Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1alpha,25-dihydroxyvitamin D(3)*. | Steroids 20010701 |
| Regulation of gene Expression by 1alpha,25-dihydroxyvitamin D3 and Its analog EB1089 under growth-inhibitory conditions in squamous carcinoma Cells. | Molecular endocrinology (Baltimore, Md.) 20010701 |
| Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis. | Frontiers in bioscience : a journal and virtual library 20010701 |
| 1alpha,25-Dihydroxyvitamin D3 and its analogues, EB1089 and CB1093, profoundly inhibit the in vitro proliferation of the human hepatoblastoma cell line HepG2. | ANZ journal of surgery 20010701 |
| Action of low calcemic 1alpha,25-dihydroxyvitamin D3 analogue EB1089 in head and neck squamous cell carcinoma. | Journal of the National Cancer Institute 20010516 |
| Correspondence re: S. E. Blutt, T. C. Polek, L. V. Stewart, M. W. Kattan, and N. L. Weigel, A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice. Cancer Res., 60: 779-782, 2000. | Cancer research 20010515 |
| Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. | Biochemical and biophysical research communications 20010309 |
| Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells. | British journal of cancer 20010301 |
| Suppressive effect of 1,25-dihydroxyvitamin D3 and its analogues EB 1089 and KH 1060 on T lymphocyte proliferation in active ulcerative colitis. | Biochemical pharmacology 20010201 |
| Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry. | Journal of mass spectrometry : JMS 20010101 |
| Effects of 1,25(OH)2D3, EB1089, and analog V on PTHrP production, PTHrP mRNA expression and cell growth in SCC 2/88. | Anticancer research 20010101 |
| Inhibition of endothelial cell activation by nitric oxide donors. | The Journal of pharmacology and experimental therapeutics 20001101 |
| Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. | Cancer research 19991001 |
| A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer. | British journal of cancer 19980701 |
| Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analog, EB1089. | Endocrinology 19980401 |
| Cytotoxic effects of 1 alpha,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line. | Cancer letters 19960227 |
| Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro. | Bone 19951001 |
| Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3. | Endocrinology 19950101 |
| EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. | Biochemical pharmacology 19921215 |