Home Other Building Blocks C-TYPE NATRIURETIC PEPTIDE (32-53) (HUMAN, PORCINE, RAT)

C-TYPE NATRIURETIC PEPTIDE (32-53) (HUMAN, PORCINE, RAT)

CAS No.:
127869-51-6
Catalog Number:
AG009AWE
Molecular Formula:
C93H157N27O28S3
Molecular Weight:
2197.6008
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
96%
1 week
United States
$265
- +
5mg
96%
1 week
United States
$890
- +
Product Description
Catalog Number:
AG009AWE
Chemical Name:
C-TYPE NATRIURETIC PEPTIDE (32-53) (HUMAN, PORCINE, RAT)
CAS Number:
127869-51-6
Molecular Formula:
C93H157N27O28S3
Molecular Weight:
2197.6008
MDL Number:
MFCD00080348
IUPAC Name:
(4R,10S,16S,19S,22S,28S,31S,34S,37S,40S,43S,49S,52R)-52-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]acetyl]amino]-40-(4-aminobutyl)-49-benzyl-28-[(2S)-butan-2-yl]-31-(3-carbamimidamidopropyl)-34-(carboxymethyl)-16,22-bis(hydroxymethyl)-10,37,43-tris(2-methylpropyl)-19-(2-methylsulfanylethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carboxylic acid
InChI:
InChI=1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1
InChI Key:
UHSBKBYWHCBDCJ-DYGWFTAGSA-N
SMILES:
NCCCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(C)C)CC(=O)O)CCCNC(=N)N)[C@H](CC)C)CO)CCSC)CO)C(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)CC(C)C)CO)CCCCN
Properties
Complexity:
4490  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
17  
Defined Bond Stereocenter Count:
0
Exact Mass:
2197.089g/mol
Formal Charge:
0
Heavy Atom Count:
151  
Hydrogen Bond Acceptor Count:
35  
Hydrogen Bond Donor Count:
32  
Isotope Atom Count:
0
Molecular Weight:
2197.62g/mol
Monoisotopic Mass:
2196.085g/mol
Rotatable Bond Count:
44  
Topological Polar Surface Area:
962A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-8.7  
Literature
Title Journal
Cardiovascular alterations at different stages of hypertension development during ethanol consumption: time-course of vascular and autonomic changes. Toxicology and applied pharmacology 20141015
Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors. Journal of molecular and cellular cardiology 20121101
Increased urinary C-type natriuretic peptide excretion may be an early marker of renal tubulointerstitial fibrosis. Peptides 20120901
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120829
C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120801
NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary. Reproduction (Cambridge, England) 20120801
C-type Natriuretic Peptide: a novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL). Peptides 20120701
C-type natriuretic peptide stimulates ovarian follicle development. Molecular endocrinology (Baltimore, Md.) 20120701
C-type natriuretic peptide forms in adult hyperthyroidism: correlation with thyroid hormones and markers of bone turnover. Clinical endocrinology 20120601
Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium. Naunyn-Schmiedeberg's archives of pharmacology 20120601
Natriuretic peptides as therapy in cardiac ischaemia/reperfusion. Danish medical journal 20120601
The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. Journal of molecular and cellular cardiology 20120501
Natriuretic peptide drug leads from snake venom. Toxicon : official journal of the International Society on Toxinology 20120315
Atorvastatin inhibits collar-induced intimal thickening of rat carotid artery: effect on C-type natriuretic peptide expression. Molecular medicine reports 20120301
Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias. Human mutation 20120101
Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. Vascular pharmacology 20120101
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's archives of pharmacology 20111201
Pre-ovulatory LH/hCG surge decreases C-type natriuretic peptide secretion by ovarian granulosa cells to promote meiotic resumption of pre-ovulatory oocytes. Human reproduction (Oxford, England) 20111101
Reversal of diabetic vasculopathy in a rat model of type 1 diabetes by opiorphin-related peptides. American journal of physiology. Heart and circulatory physiology 20111001
Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. British journal of pharmacology 20110901
Regulation of C-type natriuretic peptide expression. Peptides 20110901
Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide. Arteriosclerosis, thrombosis, and vascular biology 20110801
Salinity-dependent in vitro effects of homologous natriuretic peptides on the pituitary-interrenal axis in eels. General and comparative endocrinology 20110801
[Natriuretic peptides in the therapy of acute decompensated heart failure]. Deutsche medizinische Wochenschrift (1946) 20110801
Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation. Journal of molecular and cellular cardiology 20110701
C-type natriuretic peptide modulates quorum sensing molecule and toxin production in Pseudomonas aeruginosa. Microbiology (Reading, England) 20110701
Trabecular bone deficits among Vietnamese immigrants. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110501
Different effects of soluble and particulate guanylyl cyclases on expression of inflammatory cytokines in rat peripheral blood mononuclear cells. Immunobiology 20110301
The role of C-type natriuretic peptide in rat testes during spermatogenesis. Asian journal of andrology 20110301
Presence of dendroaspis natriuretic peptide and its binding to NPR-A receptor in rabbit kidney. Regulatory peptides 20110225
Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110201
Endogenous vasoactive peptides and the human vagina--a molecular biology and functional study. The journal of sexual medicine 20110101
Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients. Critical care (London, England) 20110101
AC-NP: a novel chimeric peptide with natriuretic and vasorelaxing actions. PloS one 20110101
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs. Arthritis research & therapy 20110101
Transforming growth factor-beta1 regulation of C-type natriuretic peptide expression in human vascular smooth muscle cells: dependence on TSC22D1. American journal of physiology. Heart and circulatory physiology 20101201
Effect of cortisol on C-type natriuretic peptide in ovine pregnancy: differential responses in fetal and placental tissues. Pediatric research 20101201
CNP/GC-B system: a new regulator of adipogenesis. Peptides 20101001
CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease. Current heart failure reports 20100901
[Vasodilatory effects of CNP on aortic arteries of rabbits]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100901
C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro. Neuroscience 20100811
Amino-terminal pro-C-type natriuretic peptide is associated with arterial stiffness, endothelial function and early atherosclerosis. Atherosclerosis 20100801
C-type natriuretic peptide as a new regulator of food intake and energy expenditure. Endocrinology 20100801
Hypoxia inducible factor-1 improves the negative functional effects of natriuretic peptide and nitric oxide signaling in hypertrophic cardiac myocytes. Life sciences 20100703
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells. Autonomic & autacoid pharmacology 20100701
Neuroprotective effects of C-type natriuretic peptide on rat retinal ganglion cells. Investigative ophthalmology & visual science 20100701
Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism: clinical and experimental 20100601
Adaptation of a corticosterone ELISA to demonstrate sequence-specific effects of angiotensin II peptides and C-type natriuretic peptide on 1alpha-hydroxycorticosterone synthesis and steroidogenic mRNAs in the elasmobranch interrenal gland. The Journal of steroid biochemistry and molecular biology 20100601
Effect of sialylated O-glycans in pro-brain natriuretic peptide stability. Clinical chemistry 20100601
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflugers Archiv : European journal of physiology 20100501
Natriuretic peptide-dependent cGMP signal pathway potentiated the relaxation of gastric smooth muscle in streptozotocin-induced diabetic rats. Digestive diseases and sciences 20100301
CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. Current opinion in investigational drugs (London, England : 2000) 20100301
Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100101
Activation of endothelial BKCa channels causes pulmonary vasodilation. Vascular pharmacology 20100101
N-terminal C-type natriuretic propeptide is associated with the endosteal apposition of bone in females with a persistent eating disorder. Hormone research in paediatrics 20100101
Characterization and functional expression of the natriuretic peptide system in human lens epithelial cells. Molecular vision 20100101
Blood serum levels of amino-terminal pro-C-type natriuretic peptide in patients with rheumatoid arthritis. Advances in medical sciences 20100101
C-type natriuretic peptide decreases hippocampal network oscillations in adult rats in vitro. Neuroscience 20091229
Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. Journal of the American Chemical Society 20091223
Vasodilators in the treatment of acute heart failure: what we know, what we don't. Heart failure reviews 20091201
Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice. American journal of physiology. Endocrinology and metabolism 20091201
Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis. Endocrinology 20091201
Natriuretic peptides: new players in energy homeostasis. Diabetes 20091201
C-type natriuretic peptide forms in pregnancy: maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology 20091001
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. Human molecular genetics 20090915
Intracellular signaling pathways involved in inhibition of PAI-1 expression by CNP in endothelial cells. Regulatory peptides 20090605
Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects. Journal of clinical pharmacology 20090601
C-type natriuretic-peptide-potentiated relaxation response of gastric smooth muscle in streptozotocin-induced diabetic rats. World journal of gastroenterology 20090507
Natriuretic peptides as regulatory mediators of secretory activity in the digestive system. Regulatory peptides 20090410
Differential effects of natriuretic peptides on arterial and venous coronary artery bypass conduits. The Annals of thoracic surgery 20090301
Role of natriuretic peptides in cGMP production in fetal cardiac bypass. The Annals of thoracic surgery 20090301
Mechanism of C-type natriuretic peptide-induced endothelial cell hyperpolarization. American journal of physiology. Lung cellular and molecular physiology 20090201
Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. BMC molecular biology 20090101
C-Type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro. Biochemical and biophysical research communications 20081219
Novel bifunctional natriuretic peptides as potential therapeutics. The Journal of biological chemistry 20081212
Effect of sex steroids on plasma C-type natriuretic peptide forms: stimulation by oestradiol in lambs and adult sheep. The Journal of endocrinology 20081201
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells. Hypertension (Dallas, Tex. : 1979) 20081101
Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. Journal of applied physiology (Bethesda, Md. : 1985) 20081001
Injection of the neuropeptide CNP into dopaminergic rat brain areas decreases alcohol intake. Annals of the New York Academy of Sciences 20081001
Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice. Peptides 20080901
Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP. Journal of the American College of Cardiology 20080701
Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. The Journal of endocrinology 20080601
Insights into natriuretic peptides in heart failure: an update. Current heart failure reports 20080601
Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries. Circulation research 20080523
Ammonia inhibits the C-type natriuretic peptide-dependent cyclic GMP synthesis and calcium accumulation in a rat brain endothelial cell line. Neurochemistry international 20080501
C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries. The journal of sexual medicine 20080501
Expression of natriuretic peptide receptor mRNA and functional response to atrial natriuretic peptide and C-type natriuretic peptide in rainbow trout (Oncorhynchus mykiss) head kidney leucocytes. Fish & shellfish immunology 20080401
C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20080401
[C-type natriuretic peptide and injured vascular diseases]. Sheng li ke xue jin zhan [Progress in physiology] 20080401
The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. Journal of cellular biochemistry 20080215
The effect of C-type natriuretic peptide on delayed rectifier potassium currents in gastric antral circular myocytes of the guinea-pig. Physiological research 20080101
C-type natriuretic peptide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. British journal of pharmacology 20080101
Evidence against C-type natriuretic peptide as an arterial 'EDHF'. British journal of pharmacology 20080101
Plasma amino-terminal pro C-type natriuretic Peptide in the neonate: relation to gestational age and postnatal linear growth. The Journal of clinical endocrinology and metabolism 20080101
Natriuretic peptides modify Pseudomonas fluorescens cytotoxicity by regulating cyclic nucleotides and modifying LPS structure. BMC microbiology 20080101
Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria. Malaria journal 20080101
C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: role of vagal afferent and efferent pathways. European journal of pharmacology 20071222
Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP. American journal of physiology. Endocrinology and metabolism 20071201
Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices. Neurotoxicology 20071101
Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormone. The Journal of clinical endocrinology and metabolism 20071101
C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas. American journal of physiology. Gastrointestinal and liver physiology 20071101
Muscarinic activity modulated by C-type natriuretic peptide in gastric smooth muscles of guinea-pig stomach. Regulatory peptides 20071004
Altered role of C-type natriuretic peptide-activated pGC-cGMP-PDE3-cAMP signaling in hyperthyroid beating rabbit atria. Regulatory peptides 20070816
Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy. Journal of molecular medicine (Berlin, Germany) 20070801
C-type natriuretic peptide forms in the ovine fetal and maternal circulations: evidence for independent regulation and reciprocal response to undernutrition. Endocrinology 20070801
Role of cardiovascular nitric oxide system in C-type natriuretic peptide effects. Biochemical and biophysical research communications 20070720
Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart. Endocrinology 20070701
Chronic nitrates blunt the effects of not only nitric oxide but also natriuretic peptides in cardiac myocytes. Pharmacological research 20070701
Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovascular research 20070601
Natriuretic peptides and therapeutic applications. Heart failure reviews 20070601
[Influence of human C-type natriuretic peptide on vascular endothelial cell proliferation]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601
Progressive and inhibitory cell cycle proteins act simultaneously to regulate neurotrophin-mediated proliferation and maturation of neuronal precursors. Cell cycle (Georgetown, Tex.) 20070502
Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American journal of physiology. Endocrinology and metabolism 20070501
Increased levels of C-type natriuretic peptide in patients with idiopathic left ventricular dysfunction. Peptides 20070501
CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis. Biochemical and biophysical research communications 20070427
C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. The Journal of physiology 20070401
Treatment of streptozotocin-induced diabetic rats with AVE7688, a vasopeptidase inhibitor: effect on vascular and neural disease. Diabetes 20070201
Negative functional effects of natriuretic peptides are attenuated in hypertrophic cardiac myocytes by reduced particulate guanylyl cyclase activity. Journal of cardiovascular pharmacology 20070201
Characterization and isolation of L-to-D-amino-acid-residue isomerase from platypus venom. Amino acids 20070101
An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie 20070101
Gentamicin decreases guanylyl cyclase activity in rat glomerulus. Kidney & blood pressure research 20070101
C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC developmental biology 20070101
A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice. BMC genetics 20070101
Role of phospholamban in cyclic GMP mediated signaling in cardiac myocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Atrial natriuretic peptide and related peptides. Clinical chemistry and laboratory medicine 20070101
Decrease of polyamine levels and enhancement of transglutaminase activity in selective reduction of B16-F10 melanoma cell proliferation induced by atrial natriuretic peptide. Melanoma research 20061201
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? Journal of cardiovascular pharmacology 20061201
Inhibitory effect of C-type natriuretic peptide on L-type calcium channel currents in gastric antral myocytes of guinea pigs. General physiology and biophysics 20061201
Natriuretic peptides levels are related to HDL-cholesterol with no influence on endothelium dependent vasodilatation. VASA. Zeitschrift fur Gefasskrankheiten 20061101
Microarray analysis of Tbx5-induced genes expressed in the developing heart. Developmental dynamics : an official publication of the American Association of Anatomists 20061001
A novel peptide from the ACEI/BPP-CNP precursor in the venom of Crotalus durissus collilineatus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001
C-type natriuretic peptide and its receptor are downregulated in pulmonary epithelium following birth. Histochemistry and cell biology 20060901
Negative inotropic effects of C-type natriuretic peptide are attenuated in hypertrophied ventricular myocytes associated with reduced cyclic GMP production. The Journal of surgical research 20060901
Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor. Clinical science (London, England : 1979) 20060901
Increase of C-type natriuretic peptide expression by serum and platelet-derived growth factor-BB in human aortic smooth muscle cells is dependent on protein kinase C activation. Endocrinology 20060901
Structural determinants of natriuretic peptide receptor specificity and degeneracy. Journal of molecular biology 20060825
Membrane guanylyl cyclase receptors: an update. Trends in endocrinology and metabolism: TEM 20060801
Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial. Circulation 20060704
C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes. Annals of the New York Academy of Sciences 20060701
[EDRF]. Nihon rinsho. Japanese journal of clinical medicine 20060701
ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord. Journal of chemical neuroanatomy 20060601
In vitro functional responses of isolated normal human prostatic tissue to compounds interacting with the cyclic guanosine monophosphate pathway. Urology 20060601
The effects of freshwater to seawater transfer on circulating levels of angiotensin II, C-type natriuretic peptide and arginine vasotocin in the euryhaline elasmobranch, Carcharhinus leucas. General and comparative endocrinology 20060515
Regulation of spontaneous contractile activity in the bovine epididymal duct by cyclic guanosine 5'-monophosphate-dependent pathways. Endocrinology 20060401
Which of the cardiac natriuretic peptides is most effective for the treatment of congestive heart failure, renal failure and cancer? Clinical and experimental pharmacology & physiology 20060301
Natriuretic peptides differentially attenuate thrombin-induced barrier dysfunction in pulmonary microvascular endothelial cells. Experimental cell research 20060215
Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice. European journal of clinical investigation 20060201
[The cardiac natriuretic peptides]. Minerva medica 20060201
Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neuroscience letters 20060116
Effects of angiotensin II and C-type natriuretic peptide on the in situ perfused trunk preparation of the dogfish, Scyliorhinus canicula. General and comparative endocrinology 20060115
Natriuretic peptide and adrenomedullin levels in chronic renal failure and effects of peritoneal dialysis. Kidney international 20060101
C-type natriuretic peptide modulates glutamate receptors on cultured rat retinal amacrine cells. Neuroscience 20060101
Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes. BMC musculoskeletal disorders 20060101
Alterations in ventricular myocyte contraction caused by C-type natriuretic peptide and nitric oxide in eNOS-/- mice. Journal of molecular and cellular cardiology 20051201
Characteristics of the renal C-type natriuretic peptide receptor in hypertrophied and developing rat kidney. Journal of molecular endocrinology 20051201
C-type natriuretic peptide applied to the brain enhances exocrine pancreatic secretion through a vagal pathway. European journal of pharmacology 20051107
C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology 20051101
Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cells. European journal of clinical investigation 20051101
NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery. Vascular pharmacology 20051001
C-type natriuretic peptide relaxes human coronary artery bypass grafts preconstricted by endothelin-1. The Annals of thoracic surgery 20051001
Differential regulation of NPR-B/GC-B by protein kinase c and calcium. Biochemical pharmacology 20050901
Plasma natriuretic peptides up to 2 years after acute myocardial infarction and relation to prognosis: an OPTIMAAL substudy. Journal of cardiac failure 20050901
C-Type natriuretic peptide and natriuretic peptide receptors are expressed by smooth muscle cells in the neointima after percutaneous coronary intervention. Atherosclerosis 20050801
C-type natriuretic peptide inhibits L-type Ca2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor. Journal of neurophysiology 20050701
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom. Toxicon : official journal of the International Society on Toxinology 20050701
Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells. Bone 20050601
C-type natriuretic peptide and guanylyl cyclase B receptor. Peptides 20050601
Cardiac and intestinal natriuretic peptides: insights from genetically modified mice. Peptides 20050601
Differential effects of cGMP produced by soluble and particulate guanylyl cyclase on mouse ventricular myocytes. Experimental biology and medicine (Maywood, N.J.) 20050401
Natriuretic peptide family: new aspects. Current medicinal chemistry. Cardiovascular and hematological agents 20050401
Functional effects of C-type natriuretic peptide and nitric oxide are attenuated in hypertrophic myocytes from pressure-overloaded mouse hearts. American journal of physiology. Heart and circulatory physiology 20050301
Four peptide hormones decrease the number of human breast adenocarcinoma cells. European journal of clinical investigation 20050101
Atrial natriuretic peptide preserves endothelial function during intimal hyperplasia. Journal of vascular research 20050101
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice. American journal of physiology. Lung cellular and molecular physiology 20041201
C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats. American journal of respiratory and critical care medicine 20041201
Vascular effects of natriuretic peptides in healthy men. Journal of cardiovascular pharmacology and therapeutics 20041201
Activation of the cGMP pathway in dopaminergic structures reduces cocaine-induced EGR-1 expression and locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20041124
Do natriuretic peptides modify arterial baroreflexes in sheep? Experimental physiology 20041101
Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation 20040907
Water deprivation enhances the inhibitory effect of natriuretic peptides on cAMP synthesis in rat renal glomeruli. American journal of physiology. Renal physiology 20040901
Functional analysis of genomic DNA, cDNA, and nucleotide sequence of the mature C-type natriuretic peptide gene in vascular cells. Arteriosclerosis, thrombosis, and vascular biology 20040901
C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress. Kidney international 20040901
[Growth promoting effect of natriuretic peptides on bones formed through endochondral ossification]. Nihon rinsho. Japanese journal of clinical medicine 20040901
[Current status and future prospects of C-type natriuretic peptide]. Nihon rinsho. Japanese journal of clinical medicine 20040901
Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus. Brain research. Developmental brain research 20040818
Dendroaspis natriuretic peptide system and its paracrine function in rat colon. Regulatory peptides 20040815
Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice. Regulatory peptides 20040615
Presence of C-type natriuretic peptide (CNP) in guinea pig caecum: role and mechanisms of CNP in circular smooth muscle relaxation. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040601
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance. Pharmacology & therapeutics 20040601
Dendroaspis natriuretic peptide and its functions in pig ovarian granulosa cells. Regulatory peptides 20040515
Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor. American journal of physiology. Heart and circulatory physiology 20040501
Bremazocine increases C-type natriuretic peptide levels in aqueous humor and enhances outflow facility. The Journal of pharmacology and experimental therapeutics 20040501
Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. Arteriosclerosis, thrombosis, and vascular biology 20040501
Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). Hypertension (Dallas, Tex. : 1979) 20040501
Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts. Kidney international 20040501
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria. Circulation research 20040416
Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20040401
The phototransduction cascade in the isolated chick pineal gland revisited. Brain research 20040305
Molecular physiology of natriuretic peptide signalling. Basic research in cardiology 20040301
Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis? British journal of pharmacology 20040301
Diagnosis of heart failure using urinary natriuretic peptides. Clinical science (London, England : 1979) 20040201
Effect of exercise on natriuretic peptides in plasma and urine in chronic heart failure. International journal of cardiology 20040201
[C-type natriuretic peptide(CNP)--a novel stimulator of bone growth formed through endochondral ossification]. Nihon rinsho. Japanese journal of clinical medicine 20040201
Natriuretic peptide system in the human retina. Molecular vision 20040109
C-type natriuretic peptide in reproduction, pregnancy and fetal development. The Journal of endocrinology 20040101
cAMP inhibits natriuretic peptide receptor-B activity and increases C-type natriuretic peptide in FRTL-5 rat thyroid cells. The Journal of endocrinology 20040101
C-type natriuretic peptide decreases soluble guanylate cyclase levels by activating the proteasome pathway. Biochimica et biophysica acta 20031207
Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect. American journal of physiology. Heart and circulatory physiology 20031201
NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion. Regulatory peptides 20031115
Renal C-type natriuretic peptide and natriuretic peptide receptor B mRNA expression are affected by water deprivation in the Spinifex Hopping mouse. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20031101
Differential relaxing responses to particulate or soluble guanylyl cyclase activation on endothelial cells: a mechanism dependent on PKG-I alpha activation by NO/cGMP. American journal of physiology. Cell physiology 20031001
Inhibitory effect of C-type natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscle of rat. Acta pharmacologica Sinica 20031001
Role of calcium-activated potassium currents in CNP-induced relaxation of gastric antral circular smooth muscle in guinea pigs. World journal of gastroenterology 20030915
Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells. Circulation research 20030905
Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B. American journal of physiology. Renal physiology 20030801
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. British journal of pharmacology 20030801
The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes. European journal of pharmacology 20030801
Furin-mediated processing of Pro-C-type natriuretic peptide. The Journal of biological chemistry 20030711
Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells. Journal of cardiovascular pharmacology 20030701
Effect of ischemia on soluble and particulate guanylyl cyclase-mediated cGMP synthesis in cardiomyocytes. American journal of physiology. Heart and circulatory physiology 20030601
Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy. The Journal of biological chemistry 20030523
Expression of guanylyl cyclase B in the human corpus cavernosum penis and the possible involvement of its ligand C-type natriuretic polypeptide in the induction of penile erection. The Journal of urology 20030501
Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals. World journal of gastroenterology 20030315
Quercetin, a phytoestrogen and dietary flavonoid, activates different membrane-bound guanylate cyclase isoforms in LLC-PK1 and PC12 cells. The Journal of pharmacy and pharmacology 20030301
Ambient salinity-dependent effects of homologous natriuretic peptides (ANP, VNP, and CNP) on plasma cortisol level in the eel. General and comparative endocrinology 20030215
Myocardial production of C-type natriuretic peptide in chronic heart failure. Circulation 20030204
Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP. Cardiovascular research 20030201
Effects of long and short hemodialysis on endothelial function: a short-term study. Kidney international 20030201
[Changes of C-type natriuretic peptide and neurotensin in rabbits brain injury induced by endotoxin]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20030201
Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells. Endocrinology 20030101
Lysophosphatidic acid inhibits C-type natriuretic peptide activation of guanylyl cyclase-B. Endocrinology 20030101
Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1. Cardiovascular drugs and therapy 20030101
Role of the cytoskeleton in secretion of chloride by shark rectal gland. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20021201
Bile secretion is centrally regulated by C-type natriuretic peptide. Cellular and molecular neurobiology 20021201
Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries. Circulation research 20021129
Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations. The Journal of biological chemistry 20021108
[Natriuretic peptides and essential arterial hypertension]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20021101
A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs). Gene 20021016
Characterization of VIP and PACAP receptors in cultured rat penis corpus cavernosum smooth muscle cells and their interaction with guanylate cyclase-B receptors. Regulatory peptides 20021015
Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. The Journal of endocrinology 20021001
Functional contribution of voltage-dependent and Ca2+ activated K+ (BK(Ca)) channels to the relaxation of guinea-pig aorta in response to natriuretic peptides. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20021001
CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome. American journal of physiology. Renal physiology 20020901
Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion. American journal of physiology. Regulatory, integrative and comparative physiology 20020901
Brain natriuretic peptide: role in cardiovascular and volume homeostasis. Seminars in nephrology 20020901
A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. Hypertension research : official journal of the Japanese Society of Hypertension 20020901
Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population. American journal of physiology. Heart and circulatory physiology 20020601
Postnatal changes in inhibitory effect of C-type natriuretic peptide on secretion of ANP. American journal of physiology. Regulatory, integrative and comparative physiology 20020601
Conformations of platypus venom C-type natriuretic peptide in aqueous solution and sodium dodecyl sulfate micelles. Toxicon : official journal of the International Society on Toxinology 20020601
Local renal and vascular natriuretic peptide system in obstructive uropathic rats. Urological research 20020501
Endothelial function in pigs transgenic for human complement regulating factor. Transplantation 20020415
Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors. The Journal of endocrinology 20020401
Nitric oxide and potassium channels are involved in brain natriuretic peptide induced vasodilatation in man. Journal of hypertension 20020301
Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice. Cardiovascular research 20020301
Functional analysis of natriuretic peptide receptors in the bladder of the toad, Bufo marinus. General and comparative endocrinology 20020201
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides. American journal of physiology. Heart and circulatory physiology 20020101
Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men. Journal of psychiatric research 20020101
C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line. Journal of bone and mineral metabolism 20020101
Mechanisms involved in the relaxation of bovine aortic endothelial cells. Life sciences 20011228
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. American journal of physiology. Heart and circulatory physiology 20011201
Activity and expression of soluble and particulate guanylate cyclases in myometrium from nonpregnant and pregnant women: down-regulation of soluble guanylate cyclase at term. The Journal of clinical endocrinology and metabolism 20011201
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle. European journal of pharmacology 20011102
Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria. American journal of physiology. Regulatory, integrative and comparative physiology 20011101
A critical review of the role of endothelial factors in the pathogenesis of hypertension. Journal of cardiovascular pharmacology 20011101
C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. The European journal of neuroscience 20011101
Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility. American journal of physiology. Heart and circulatory physiology 20011001
Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides. Atherosclerosis 20010901
Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. The Biochemical journal 20010901
Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science (New York, N.Y.) 20010831
Regulation of mesangial cell function by vasodilatory signaling molecules. Cardiovascular research 20010815
Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus. Cardiovascular research 20010815
Relaxant effect of C-type natriuretic peptide involves endothelium and nitric oxide-cGMP system in rat coronary microvasculature. Cardiovascular research 20010815
C-type natriuretic peptide system in fetal ovine pulmonary vasculature. American journal of physiology. Lung cellular and molecular physiology 20010801
Natriuretic peptides stimulate steroidogenesis in the fetal rat testis. Biology of reproduction 20010801
The effects of C-type natriuretic peptide on catecholamine release in the pacific spiny dogfish (Squalus acanthias). General and comparative endocrinology 20010801
Opposing effects of endothelin-1 on C-type natriuretic peptide actions in rat cardiomyocytes. European journal of pharmacology 20010706
Molecular and biochemical characterization of a CNP-sensitive guanylyl cyclase in bovine tracheal smooth muscle. American journal of respiratory cell and molecular biology 20010701
Contractility of late pregnant rat myometrium is refractory to activation of soluble but not particulate guanylate cyclase. American journal of obstetrics and gynecology 20010701
Physiological antagonism of endothelin-1 in human conductance and resistance coronary artery. British journal of pharmacology 20010601
C-type natriuretic peptide is synthesized and secreted from leukemia cell lines, peripheral blood cells, and peritoneal macrophages. Experimental hematology 20010501
Imbalance between interleukin-6 and adrenomedullin mRNA levels in peripheral blood mononuclear cells of patients with lupus nephritis. Clinical and experimental immunology 20010501
Activation of guanylate cyclase by natriuretic peptides in mouse pituitary AtT20 cells is influenced by phosphorylation of ANP. Neurochemical research 20010501
[The vasodilation and its mechanism of C-type natriuretic peptide]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20010501
Vasoactivity of the ventral aorta of the American eel (Anguilla rostrata), Atlantic hagfish ( Myxine glutinosa), and sea lamprey (Petromyzon marinus). The Journal of experimental zoology 20010415
C-type natriuretic peptide-induced vasodilation is dependent on hyperpolarization in human forearm resistance vessels. Hypertension (Dallas, Tex. : 1979) 20010401
Alpha-helical-corticotropin-releasing hormone reverses anxiogenic effects of C-type natriuretic peptide in rats. Brain research 20010302
Cardiac natriuretic peptides and pancreatic islet blood flow in anesthetized rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010301
C-type natriuretic peptide has a negative inotropic effect on cardiac myocytes. European journal of pharmacology 20010202
Differential expression and synthesis of natriuretic peptides determines natriuretic peptide receptor expression in primary cultures of human proximal tubular cells. Journal of hypertension 20010201
Cardiac natriuretic peptides--hope or hype? Journal of clinical pharmacy and therapeutics 20010201
ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep. American journal of physiology. Regulatory, integrative and comparative physiology 20010101
C-type natriuretic peptide concentrations in the plasma and cerebrospinal fluid of patients with subarachnoid hemorrhage. Critical care (London, England) 20010101
Possibility of age regulation of the natriuretic peptide C-receptor in human platelets. Journal of endocrinological investigation 20010101
Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. Journal of molecular endocrinology 20000601
Natriuretic peptides and nitric oxide induce endothelial apoptosis via a cGMP-dependent mechanism. Arteriosclerosis, thrombosis, and vascular biology 19990101
Mechanisms of FK 506-induced hypertension in the rat. Hypertension (Dallas, Tex. : 1979) 19990101
Estradiol induces C-type natriuretic peptide gene expression in mouse uterus. The American journal of physiology 19971201
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