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BQ-123

CAS No.:
136553-81-6
Catalog Number:
AG009ARV
Molecular Formula:
C31H42N6O7
Molecular Weight:
610.7012
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
1 week
United States
$196
- +
5mg
95%
1 week
United States
$612
- +
10mg
95%
1 week
United States
$1029
- +
Product Description
Catalog Number:
AG009ARV
Chemical Name:
BQ-123
CAS Number:
136553-81-6
Molecular Formula:
C31H42N6O7
Molecular Weight:
610.7012
MDL Number:
MFCD00133204
IUPAC Name:
2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
InChI:
InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
InChI Key:
VYCMAAOURFJIHD-PJNXIOHISA-N
SMILES:
CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C
UNII:
S2A8YZM151
Properties
Complexity:
1110  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
610.311g/mol
Formal Charge:
0
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
610.712g/mol
Monoisotopic Mass:
610.311g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
190A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. British journal of pharmacology 20160401
BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicology and applied pharmacology 20150201
Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. The American journal of pathology 20141101
Selective ET(A) receptor blockade protects against cisplatin-induced acute renal failure in male rats. European journal of pharmacology 20140505
Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochimica et biophysica acta 20140201
Interplay between endothelin and erythropoietin in astroglia: the role in protection against hypoxia. International journal of molecular sciences 20140201
Endothelin-1 increases superoxide production in human coronary artery bypass grafts. Life sciences 20121015
The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway. Life sciences 20121015
The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-κB signaling pathway in heart. General physiology and biophysics 20120901
Cathepsin E induces itch-related response through the production of endothelin-1 in mice. European journal of pharmacology 20120705
Agonist-dependent modulation of arterial endothelinA receptor function. British journal of pharmacology 20120701
Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension (Dallas, Tex. : 1979) 20120701
Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Investigative ophthalmology & visual science 20120608
Ouabain stimulates atrial natriuretic peptide secretion via the endothelin-1/ET(B) receptor-mediated pathway in beating rabbit atria. Life sciences 20120522
Elevated endothelin-1 vasoconstrictor tone in prehypertensive adults. The Canadian journal of cardiology 20120501
EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology 20120401
Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. PloS one 20120101
Fluorescence correlation spectroscopy in drug discovery: study of Alexa532-endothelin 1 binding to the endothelin ETA receptor to describe the pharmacological profile of natural products. TheScientificWorldJournal 20120101
Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase. Journal of vascular research 20120101
Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats. PloS one 20120101
Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes. Mechanisms of ageing and development 20120101
ETA and ETB receptors are expressed in vascular adventitial fibroblasts. American journal of physiology. Heart and circulatory physiology 20111201
Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. Clinical orthopaedics and related research 20111101
Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition. The journal of physiological sciences : JPS 20111101
Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy. American journal of physiology. Heart and circulatory physiology 20111001
Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes. Biochemical and biophysical research communications 20110930
Exogenous ghrelin improves blood flow distribution in pulmonary hypertension-assessed using synchrotron radiation microangiography. Pflugers Archiv : European journal of physiology 20110901
Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men. Clinical science (London, England : 1979) 20110601
Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway. American journal of physiology. Lung cellular and molecular physiology 20110601
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow. Life sciences 20110425
20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. American journal of physiology. Heart and circulatory physiology 20110401
Effect of avosentan (SPP-301) in porcine ciliary arteries. Current eye research 20110201
From a molecular biological viewpoint, does endothelin type A receptor antagonist therapy reduce diabetes-induced testicular damage in rats? Urology 20110101
Endothelin-A receptor antagonists prevent amyloid-β-induced increase in ETA receptor expression, oxidative stress, and cognitive impairment. Journal of Alzheimer's disease : JAD 20110101
Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis. Arthritis research & therapy 20110101
Protective effects of endothelin-A receptor antagonist BQ123 against LPS-induced oxidative stress in lungs. Pharmacological reports : PR 20110101
Glial response to lipopolysaccharide: possible role of endothelins. Peptides 20101201
Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. Clinical and experimental pharmacology & physiology 20101201
Endothelin receptor antagonist BQ-123 ameliorates myocardial ischemic-reperfusion injury in rats: a hemodynamic, biochemical, histopathological and electron microscopic evidence. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20101101
Molecular signaling of pruritus induced by endothelin-1 in mice. Experimental biology and medicine (Maywood, N.J.) 20101101
Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. European journal of pharmacology 20101010
Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. Circulation 20100914
Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Microcirculation (New York, N.Y. : 1994) 20100801
Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. Circulation research 20100723
Endothelin-A receptor antagonism attenuates carcinoma-induced pain through opioids in mice. The journal of pain : official journal of the American Pain Society 20100701
Endothelin-1-induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC-alpha signaling pathways. Surgery 20100601
Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Molecular neurobiology 20100601
Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure. Canadian journal of physiology and pharmacology 20100601
Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. Canadian journal of physiology and pharmacology 20100601
Endothelium-derived endothelin-1. Pflugers Archiv : European journal of physiology 20100501
Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro. The Journal of clinical endocrinology and metabolism 20100501
[The mechanism and pulmonary-protective effects of endothelin-1 receptor antagonist in chronic obstructive pulmonary diseases rat model]. Zhonghua nei ke za zhi 20100501
The vasodilatory effect of juxta-arteriolar microinjection of endothelinA receptor inhibitor in healthy and acute branch retinal vein occlusion minipig retinas. Investigative ophthalmology & visual science 20100401
Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. The European respiratory journal 20100401
Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment. Hypertension (Dallas, Tex. : 1979) 20100301
Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults. American journal of physiology. Regulatory, integrative and comparative physiology 20100201
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides 20100201
Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans. Obesity (Silver Spring, Md.) 20100101
Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure. Heart failure reviews 20100101
Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction. Reproduction, fertility, and development 20100101
Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension (Dallas, Tex. : 1979) 20091201
Endothelin-1 induces the expression of C-reactive protein in rat vascular smooth muscle cells. Biochemical and biophysical research communications 20091120
[Cardioprotection of ramipril and BQ-123 against myocardial ischemia/reperfusion injury in vivo in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20091101
Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin. American journal of physiology. Regulatory, integrative and comparative physiology 20090801
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. Neuroscience letters 20090703
Functional and molecular characterization of the endothelin system in retinal arterioles. Investigative ophthalmology & visual science 20090701
Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease. Hypertension (Dallas, Tex. : 1979) 20090701
Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart. Experimental physiology 20090601
Improved endothelial function after endothelin receptor blockade in patients with systemic sclerosis. Arthritis and rheumatism 20090601
Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. American journal of physiology. Heart and circulatory physiology 20090501
Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. Arteriosclerosis, thrombosis, and vascular biology 20090401
The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat. Anesthesia and analgesia 20090101
Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism. Journal of nephrology 20090101
Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes. Vascular health and risk management 20090101
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma. International immunopharmacology 20081220
Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovascular toxicology 20081201
Regulation of glial inflammatory mediators synthesis: possible role of endothelins. Peptides 20081201
Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circulation research 20081107
Endothelium-derived vasoconstriction by purines and pyrimidines. Circulation research 20081107
Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in cats. Investigative ophthalmology & visual science 20081001
Pharmacological characterization of 3-azabicyclo[3,2,1] octane-1-yl-l-leucyl-d-tryptophanyl-d-4-Cl-phenylalanine: A novel ET(A) receptor-selective antagonist. Pulmonary pharmacology & therapeutics 20081001
The endothelin-converting enzyme-1/endothelin-1 pathway plays a critical role in inflammation-associated premature delivery in a mouse model. The American journal of pathology 20081001
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1. Journal of leukocyte biology 20080901
Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)H oxidase-derived superoxide. The Journal of pharmacology and experimental therapeutics 20080901
Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. American journal of physiology. Heart and circulatory physiology 20080901
The role of endothelin pathway in modulation of airway reactivity to methacholine in C57Bl/6 and BALB/c mice. European journal of pharmacology 20080820
ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo. American journal of physiology. Renal physiology 20080801
Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes. Canadian journal of physiology and pharmacology 20080801
Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats. British journal of pharmacology 20080701
Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. American journal of physiology. Heart and circulatory physiology 20080601
Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats. Pharmacological research 20080601
Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferation. Canadian journal of physiology and pharmacology 20080601
Central endothelin: effects on vasopressin and the arterial baroreflex in doxorubicin heart failure rats. Canadian journal of physiology and pharmacology 20080601
Potentiation of 2-methoxyestradiol-induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells. The Prostate 20080501
Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder. The journal of sexual medicine 20080501
Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum. Biology of reproduction 20080401
Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion. American journal of physiology. Heart and circulatory physiology 20080201
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. American journal of physiology. Lung cellular and molecular physiology 20080201
Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium. Naunyn-Schmiedeberg's archives of pharmacology 20080201
Expression of the hyperpolarization-activated current, I(f), in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors. Pharmacological research 20080201
Effects of endothelin-1 1-31 on cell viabililty and [Ca2+]i in cultured neonatal rat cardiomyocytes. Physiological research 20080101
The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo. Journal of vascular research 20080101
19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy. Magnetic resonance in medicine 20080101
Endothelin-1 potentiation of coronary artery contraction after ischemia-reperfusion. Vascular pharmacology 20080101
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. Journal of cardiovascular pharmacology 20071201
Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes. American journal of physiology. Heart and circulatory physiology 20071001
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. Cardiovascular research 20070901
Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme. Biological & pharmaceutical bulletin 20070701
Endothelin-1 and pancreatic islet vasculature: studies in vivo and on isolated, vascularly perfused pancreatic islets. American journal of physiology. Endocrinology and metabolism 20070601
Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain. European journal of pain (London, England) 20070501
Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. British journal of pharmacology 20070501
Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B. Hypertension (Dallas, Tex. : 1979) 20070501
Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibition prevents endothelin A receptor antagonism in rat aorta. American journal of physiology. Heart and circulatory physiology 20070401
Endothelins mediate neutrophil activation, ProMMP-9 release and endothelial cell detachment. Inflammation 20070401
Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock. Shock (Augusta, Ga.) 20070401
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circulation research 20070330
Endothelin-1 induces functionally active CD40 protein via nuclear factor-kappaB in human vascular smooth muscle cells. European journal of medical research 20070326
Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease. Diabetes care 20070301
Endothelin limits insulin action in obese/insulin-resistant humans. Diabetes 20070301
Intraindividual comparison of human radial and internal thoracic arteries in vitro and the effect of preoperative calcium blocker therapy. Fundamental & clinical pharmacology 20070201
Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation. Hypertension (Dallas, Tex. : 1979) 20070101
Endothelin-1-mediated wave-like [Ca2+]i oscillations in intact rabbit inferior vena cava. Journal of vascular research 20070101
Protection from renal ischemia reperfusion injury by an endothelin-A receptor antagonist BQ-123 in relation to nitric oxide production. Toxicology 20061207
Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells. Journal of cellular biochemistry 20061001
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats. American journal of physiology. Heart and circulatory physiology 20061001
Impaired effect of endothelin-1 on coronary artery stiffness in type 2 diabetes. International journal of cardiology 20060920
Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells. Molecules and cells 20060831
Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. The Journal of pharmacology and experimental therapeutics 20060801
Cerebrovascular dysfunction is an attractive target for therapy in heat stroke. Clinical and experimental pharmacology & physiology 20060801
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. Pain 20060701
Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701
Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta. British journal of pharmacology 20060601
Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21). Experimental biology and medicine (Maywood, N.J.) 20060601
Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. Experimental biology and medicine (Maywood, N.J.) 20060601
Effect of BQ-123 and nitric oxide inhibition on liver in rats after renal ischemia-reperfusion injury. General physiology and biophysics 20060601
Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors. American journal of physiology. Gastrointestinal and liver physiology 20060501
Effects of antagonists for endothelin ET(A) and ET(B) receptors on coronary endothelial and myocardial function after ischemia-reperfusion in anesthetized goats. Vascular pharmacology 20060501
Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo. Journal of cardiovascular pharmacology 20060501
ETa-receptor blockade, but not ACE inhibition, blunts retinal vessel response during isometric exercise. American journal of physiology. Heart and circulatory physiology 20060401
Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters. Vascular pharmacology 20060401
Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes. European journal of pharmacology 20060318
Effect of age on insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats. Experimental gerontology 20060301
Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance. Journal of cardiovascular pharmacology 20060301
Difference in the characteristics of ETA-receptor-stimulated response between rat small pulmonary and renal arteries. Journal of cardiovascular pharmacology 20060301
Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury. Toxicology 20060215
Pulmonary perfusion during lipopolysaccharide (LPS) induced fetal endotoxemia in the preterm fetal sheep. European journal of obstetrics, gynecology, and reproductive biology 20060201
Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Molecular pharmacology 20060201
Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway. Hypertension (Dallas, Tex. : 1979) 20060201
Involvement of endothelium and endothelin-1 in lead-induced smooth muscle cell dysfunction in rats. Kidney international 20060201
Pharmacological properties of endothelin-1 in the rabbit corpus cavernosum. In vivo (Athens, Greece) 20060101
Endothelin(B) receptor blocker inhibits high glucose-induced synthesis of fibronectin in human peritoneal mesothelial cells. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20060101
Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. Canadian journal of physiology and pharmacology 20060101
Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists. Brain research 20051207
Endothelin-1 enhances glutamate-induced retinal cell death, possibly through ETA receptors. Investigative ophthalmology & visual science 20051201
Blood pressure responses of endothelin-1 1-31 within the rostral ventrolateral medulla through conversion to endothelin-1 1-21. Journal of cardiovascular pharmacology 20051201
Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger. Fundamental & clinical pharmacology 20051201
Endothelin-1 receptor antagonist BQ123 prevents pulmonary artery hypertension induced by low ambient temperature in broilers. Biological & pharmaceutical bulletin 20051201
Endothelins: pathophysiology and treatment implications in chronic heart failure. Current heart failure reports 20051201
Pathways of glomerular toxicity of cyclosporine-A: an 'in vitro' study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201
Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids. European journal of pharmacology 20051107
Effect of chymase on intraocular pressure in rabbits. European journal of pharmacology 20051107
Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats. The Journal of pharmacology and experimental therapeutics 20051101
Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation. British journal of pharmacology 20051101
Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries. Journal of cardiovascular pharmacology 20051001
[Effects of airway epithelium injury on the transdifferentiation of sub-epithelial fibroblasts and its role in the development of airway hyperresponsiveness in asthma]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20051001
Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20050901
Systemic endothelial dysfunction in adults with cyanotic congenital heart disease. Circulation 20050823
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle. European journal of pharmacology 20050711
Nitric oxide inhibition unmasks ischemic myocardium-derived vasoconstrictor signals activating endothelin type A receptor of coronary microvessels. American journal of physiology. Heart and circulatory physiology 20050701
Endothelin isoforms and the response to myocardial stretch. American journal of physiology. Heart and circulatory physiology 20050601
The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504
Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1. American journal of physiology. Gastrointestinal and liver physiology 20050501
Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovascular research 20050501
Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. Journal of hypertension 20050501
Endothelin receptors in lower esophageal sphincter circular smooth muscle. Regulatory peptides 20050415
[H]BQ-123 binding to native endothelin ET(A) receptors in human astrocytoma 1321N1 cells and screening of potential ligands. Pharmacology 20050401
Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch. The Canadian journal of cardiology 20050401
Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats. Toxicon : official journal of the International Society on Toxinology 20050315
Endothelin mediates superoxide production in angiotensin II-induced hypertension in rats. Free radical biology & medicine 20050301
Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition. Journal of internal medicine 20050301
Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway. Experimental eye research 20050301
Insulin and endothelin in the acute regulation of adiponectin in vivo in humans. Obesity research 20050301
Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia. Journal of neuroscience research 20050201
Intercellular communication via gap junctions in activated rat hepatic stellate cells. Gastroenterology 20050201
[Changes of activity of the endothelial system in experimental heart failure]. Kardiologiia 20050101
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 20041125
Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery. Peptides 20041101
A novel combination of opiates and endothelin antagonists to manage pain without any tolerance development. Journal of cardiovascular pharmacology 20041101
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. Journal of cardiovascular pharmacology 20041101
The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants. Journal of cardiovascular pharmacology 20041101
Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II. Journal of cardiovascular pharmacology 20041101
Inhibitory actions of endothelin-1 on pain processing. Journal of cardiovascular pharmacology 20041101
Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist. Journal of cardiovascular pharmacology 20041101
The effect of cerivastatin therapy on vascular responses to endothelin antagonists in humans. Journal of cardiovascular pharmacology 20041101
Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C. European journal of pharmacology 20041006
Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II. Journal of hypertension 20041001
Endothelin ETB receptor signaling in the median eminence and subfornical organ of the rat brain. Neuropeptides 20041001
Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism. Journal of the American Society of Nephrology : JASN 20041001
Prior antagonism of endothelin-1A receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke. Journal of pharmacological sciences 20041001
Association of endothelin with lung hemorrhage induced by immune complexes in rats. Inflammation 20041001
Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. European journal of pharmacology 20040913
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Molecular pharmacology 20040901
Endothelin upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. Metabolism: clinical and experimental 20040901
Endothelin-1-mediated coronary vasoconstriction deteriorates myocardial depression in hearts isolated from lipopolysaccharide-treated rats: interaction with nitric oxide. Clinical and experimental pharmacology & physiology 20040901
[Endothelin-1 and arteriosclerosis]. Nihon rinsho. Japanese journal of clinical medicine 20040901
[Prospects for endothelin-related drugs]. Nihon rinsho. Japanese journal of clinical medicine 20040901
Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types. American journal of physiology. Heart and circulatory physiology 20040801
Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner. The Journal of pharmacology and experimental therapeutics 20040801
Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis. Fundamental & clinical pharmacology 20040801
Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation. The Journal of pharmacology and experimental therapeutics 20040701
Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide. British journal of clinical pharmacology 20040601
Endothelin-induced constriction of the ductus venosus in fetal sheep: developmental aspects and possible interaction with vasodilatory prostaglandin. British journal of pharmacology 20040601
[Endothelin]. Nihon rinsho. Japanese journal of clinical medicine 20040601
Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cells. Hypertension research : official journal of the Japanese Society of Hypertension 20040601
Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor. Endocrinology 20040501
ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo. American journal of physiology. Heart and circulatory physiology 20040401
Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants. American journal of physiology. Endocrinology and metabolism 20040401
Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats. European journal of clinical investigation 20040401
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice. Cellular and molecular neurobiology 20040401
Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors. Regulatory peptides 20040315
Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery. European journal of pharmacology 20040223
Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1. European journal of pharmacology 20040213
The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release. Journal of cardiovascular pharmacology 20040201
Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. British journal of pharmacology 20040201
Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats. British journal of pharmacology 20040201
Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle. American journal of physiology. Renal physiology 20040101
In-vivo interaction of nitric oxide and endothelin. Journal of hypertension 20040101
Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. Circulation research 20031212
Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure. American journal of physiology. Heart and circulatory physiology 20031001
Endothelin-A receptors mediate renal hemodynamic effects of exogenous Angiotensin II in humans. Hypertension (Dallas, Tex. : 1979) 20031001
[Involvement of endothelin in the proliferative effect of lysophosphatidic acid on vascular smooth muscle cells in rats]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20031001
Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. Brain research 20030815
Reduction of nitrite production by endothelin-1 in isolated porcine ciliary processes. Experimental eye research 20030801
Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. The American journal of pathology 20030801
Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons. Neuropeptides 20030801
Endothelin-1 is a potent regulator in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells. Peptides 20030801
Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. American journal of physiology. Heart and circulatory physiology 20030701
Endothelin-1 and vascular tone in subjects with atherogenic risk factors. Hypertension (Dallas, Tex. : 1979) 20030701
Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. British journal of pharmacology 20030701
Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. The Journal of physiology 20030615
Hemodynamic and proinflammatory actions of endothelin-1 in guinea pig small intestine submucosal microcirculation. American journal of physiology. Gastrointestinal and liver physiology 20030601
Role of endothelin ETA and ETB receptors in the guinea-pig urinary bladder contraction. European journal of pharmacology 20030530
Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct. Regulatory peptides 20030515
Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro. Hypertension (Dallas, Tex. : 1979) 20030501
Regulation of human retinal blood flow by endothelin-1. Experimental eye research 20030501
Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. Naunyn-Schmiedeberg's archives of pharmacology 20030501
Pharmacological characterization of TA-0201, an endothelin receptor antagonist, with recombinant and human prostate endothelin receptors. European journal of pharmacology 20030425
Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats. Peptides 20030401
Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs. European journal of pharmacology 20030328
Will endothelin receptor antagonists have a role in heart failure? The Medical clinics of North America 20030301
Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1. Cellular signalling 20030201
Role of endothelin-1 in choroidal blood flow regulation during isometric exercise in healthy humans. Investigative ophthalmology & visual science 20030201
Effect of endothelin-1 (1-31) on the renal resistance vessels. The journal of medical investigation : JMI 20030201
ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. Journal of cardiovascular pharmacology 20030101
Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and high-to-normal renin hypertension. Cardiovascular research 20030101
Role of K+ATP channels, endothelin A receptors, and effect of angiotensin II on blood flow in oral tissues. Journal of dental research 20030101
Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia. Acta radiologica (Stockholm, Sweden : 1987) 20030101
Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach. Journal of pharmacological sciences 20030101
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells. American journal of physiology. Heart and circulatory physiology 20021201
Insulin sensitivity and big ET-1 conversion to ET-1 after ETA- or ETB-receptor blockade in humans. Journal of applied physiology (Bethesda, Md. : 1985) 20021201
Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide. Stroke 20021201
Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein. Journal of Alzheimer's disease : JAD 20021201
Role of endothelin type B receptor in NO/cGMP signaling pathway in rat median eminence. Cellular and molecular neurobiology 20021201
Mechanism of endothelin-1-induced cytosolic Ca(2+) mobility in cultured H9c2 myocardiac ventricular cells. Cellular signalling 20021001
Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed. American journal of physiology. Heart and circulatory physiology 20021001
Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 20021001
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro. Pharmacological research 20021001
Potentiation of morphine analgesia by BQ123, an endothelin antagonist. Peptides 20021001
The vascular endothelin system is not overactive in normotensive hemodialysis patients. Kidney international 20020901
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. European journal of immunology 20020901
Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat. Molecular reproduction and development 20020901
Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens. Planta medica 20020901
Possible mechanism of endothelin-induced Ca2+ mobility in A7r5 cultured vascular smooth muscle cells. The Kaohsiung journal of medical sciences 20020901
Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Pharmacogenetics 20020801
Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension. Clinical science (London, England : 1979) 20020801
Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung. Clinical science (London, England : 1979) 20020801
Modulation of ET(B) receptor-induced arginine-vasopressin secretion by N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA)-dependent mechanisms in hypothalamo-neurohypophysial explants. Clinical science (London, England : 1979) 20020801
Differential vasoactive response to endothelin receptor antagonists and prostacyclin in patients with severe pulmonary hypertension. Clinical science (London, England : 1979) 20020801
Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways. Clinical science (London, England : 1979) 20020801
Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet. Clinical science (London, England : 1979) 20020801
Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl. Clinical science (London, England : 1979) 20020801
Altered mitogen-activated protein kinase activation in vascular smooth muscle cells from spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology 20020701
Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors. Circulation 20020618
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacological reviews 20020601
Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects. Clinical science (London, England : 1979) 20020601
Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. The Journal of thoracic and cardiovascular surgery 20020601
Pronatriuretic peptide is a sensitive marker of the endocrine function of teleost heart. American journal of physiology. Endocrinology and metabolism 20020401
Endothelin ETA receptor-subtype specific antagonism does not mitigate the acute systemic or renal effects of exogenous angiotensin II in humans. European journal of clinical investigation 20020401
Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. The Annals of thoracic surgery 20020401
A novel bioactive 31-amino acid ET-1 peptide stimulates eosinophil recruitment and increases the levels of eotaxin and IL-5. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401
Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cellular and molecular neurobiology 20020401
Endothelin-A receptors and NO mediate decrease in arterial pressure during recovery from restraint. American journal of physiology. Regulatory, integrative and comparative physiology 20020301
Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis. Clinical science (London, England : 1979) 20020301
Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells. Biochemical pharmacology 20020301
Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro. Journal of gastroenterology and hepatology 20020301
Endothelial modulation of skeletal muscle blood flow and VO(2) during low- and high-intensity contractions. Journal of applied physiology (Bethesda, Md. : 1985) 20020201
Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation 20020129
Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart. European journal of pharmacology 20020102
Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth. The Journal of clinical endocrinology and metabolism 20020101
Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Neuroreport 20011204
Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade. Circulation research 20011123
Myocardial contractile responsiveness to endothelin-1 in the post-infarction rat model of heart failure: effects of chronic quinapril. Journal of molecular and cellular cardiology 20011101
Rationale and perspective of endothelin-1 antagonism in acute heart failure. Journal of cardiovascular pharmacology 20011101
Autocrine regulation of prolactin secretion by endothelins: a permissive role for estradiol. Endocrine 20011101
Endothelin-1 induces contraction of human and Australian possum gallbladder in vitro. Regulatory peptides 20011015
Endothelin receptor blockade and nitric oxide bioactivity. Cardiovascular research 20011001
[Down-regulation of ETA receptor of vascular smooth muscle cells by 17 beta-estradiol]. Sheng li xue bao : [Acta physiologica Sinica] 20011001
Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation 20010904
Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man. British journal of clinical pharmacology 20010801
Differential desensitization of Ca2+ mobilization and vasoconstriction by ET(A) receptors in the gerbil spiral modiolar artery. The Journal of membrane biology 20010801
Endothelin mediates some of the renal actions of acutely administered angiotensin II. Hypertension (Dallas, Tex. : 1979) 20010701
Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats. European journal of pharmacology 20010629
Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe. Biology of reproduction 20010601
Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro. Japanese journal of pharmacology 20010601
Paradoxically enhanced endothelin-B receptor-mediated vasoconstriction in conscious old monkeys. Circulation 20010515
Functional and biochemical evidence for capsaicin-induced neural endothelin release in isolated working rat heart. European journal of pharmacology 20010511
A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes. American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu-)-Na+, forming five and six coordination bonds between sodium ions and peptides. Acta crystallographica. Section D, Biological crystallography 20010501
The polycationic aminoglycosides modulate the vasoconstrictive effects of endothelin: relevance to cerebral vasospasm. British journal of pharmacology 20010501
Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? Journal of the American College of Cardiology 20010501
Pulmonary adrenomedullin counteracts deterioration of coronary flow and myocardial performance evoked by pulmonary endothelins in experimental acute respiratory distress syndrome. Critical care medicine 20010501
Endothelin receptors in human and guinea-pig gallbladder muscle. Regulatory peptides 20010420
Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin. The Journal of pharmacology and experimental therapeutics 20010401
Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats. Hepatology (Baltimore, Md.) 20010401
Effect of the blood substitute diaspirin crosslinked hemoglobin in rat mesenteric and human radial collateral arteries. Journal of cardiovascular pharmacology 20010401
Effects of endothelin-1 and nitric oxide on proliferation of cultured guinea pig bronchial smooth muscle cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010401
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex. International journal of molecular medicine 20010301
Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells. The American journal of pathology 20010301
Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation. Naunyn-Schmiedeberg's archives of pharmacology 20010301
Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits. Journal of neurosurgery 20010201
Endothelin antagonism uncovers insulin-mediated vasorelaxation in vitro and in vivo. Hypertension (Dallas, Tex. : 1979) 20010201
Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads. Bioorganic & medicinal chemistry 20010201
Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells. European journal of pharmacology 20010105
Endothelin receptor blockade improves endothelial function in human internal mammary arteries. Cardiovascular research 20010101
A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptors. British journal of pharmacology 20010101
Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle. Pflugers Archiv : European journal of physiology 20010101
Bone blood flow and vascular reactivity. Cells, tissues, organs 20010101
Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. Molecular pharmacology 20001201
Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. Journal of mass spectrometry : JMS 20000201
Angiotensin II receptor blockade unmasks a depressor response to endothelin antagonists in rats. Fundamental & clinical pharmacology 20000101
Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus. British journal of pharmacology 19990701
Novel sodium binding properties of some cyclopentapeptide endothelin A selective receptor antagonists: electrospray and fast-atom-bombardment mass spectrometric studies. Biochemical and biophysical research communications 19990127
Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy. Cardiovascular research 19980901
Role of endothelin in the human craniofacial morphogenesis. Journal of craniofacial genetics and developmental biology 19980101
Endothelin receptor-mediated Ca2+ mobilization and contraction in bovine oviductal arteries: comparison with noradrenaline and potassium. General pharmacology 19971001
Endothelin ETA receptors subtype mediates phosphoinositide hydrolysis in adrenal medulla. Archives of physiology and biochemistry 19970901
Excitatory gastric motor and cardiovascular effects of endothelins in the dorsal vagal complex are mediated through ET(A) receptors. The Journal of pharmacology and experimental therapeutics 19970801
Rediscovering an endothelin antagonist (BQ-123): a self-deconvoluting cyclic pentapeptide library. Journal of medicinal chemistry 19960913
Endothelin-1 stimulates deoxyribonucleic acid synthesis and contraction in testicular peritubular myoid cells. Biology of reproduction 19960301
Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes. Pflugers Archiv : European journal of physiology 19960201
Endothelin-induced nociception in mice: mediation by ETA and ETB receptors. The Journal of pharmacology and experimental therapeutics 19960201
Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin. Critical care medicine 19960101
The effect of endothelin-2 (ET-2) on migration and changes in cytosolic free calcium of neutrophils. Naunyn-Schmiedeberg's archives of pharmacology 19960101
Endothelin acts as a paracrine regulator of stretch-induced atrial natriuretic peptide release. The American journal of physiology 19951101
Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. Journal of medicinal chemistry 19951013
[Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats]. Archives des maladies du coeur et des vaisseaux 19950801
ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. British journal of pharmacology 19950501
Nonpeptide endothelin receptor antagonists: IV. Identification of receptors in rabbit colonic mucosa and smooth muscle and correlation with physiological effects. The Journal of pharmacology and experimental therapeutics 19950301
[3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. European journal of pharmacology 19950214
In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats. Circulation 19950201
Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists. European journal of pharmacology 19941212
Solvent effects on the conformation of cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-). An NMR spectroscopy and molecular modeling study. International journal of peptide and protein research 19940501
Mutational analysis of human endothelin receptors ETA and ETB identification of regions involved in the selectivity for endothelin 3 or cyclo-(D-Trp-D-Asp-Pro-D-Val-Leu). European journal of biochemistry 19940501
Differential blockade of the renal vasoconstrictor and diuretic responses to endothelin-1 by endothelin antagonist. Clinical and experimental pharmacology & physiology 19940401
Characterization of iris sphincter smooth muscle endothelin receptor subtypes which are coupled to cyclic AMP formation and polyphosphoinositide hydrolysis. The Journal of pharmacology and experimental therapeutics 19940301
[125I]-PD151242: a selective radioligand for human ETA receptors. British journal of pharmacology 19940101
Reversal of subarachnoid hemorrhage-induced vasoconstriction with an endothelin receptor antagonist. Neurosurgery 19940101
A conformational study by 1H NMR of a cyclic pentapeptide antagonist of endothelin. Journal of medicinal chemistry 19930903
Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta. The American journal of physiology 19930301
BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu), is a non-competitive antagonist of the actions of endothelin-1 in SK-N-MC human neuroblastoma cells. Biochemical and biophysical research communications 19920415
Solution conformation of a cyclic pentapeptide endothelin antagonist. Comparison of structures obtained from constrained dynamics and conformational search. FEBS letters 19920316
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin-A receptor-selective antagonist. FEBS letters 19920113
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