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Home Other Building Blocks 5-HYDROXY LANSOPRAZOLE

5-HYDROXY LANSOPRAZOLE

CAS No.:
131926-98-2
Catalog Number:
AG009AH4
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG009AH4
Chemical Name:
5-HYDROXY LANSOPRAZOLE
CAS Number:
131926-98-2
MDL Number:
MFCD00950815
IUPAC Name:
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-3H-benzimidazol-5-ol
InChI:
InChI=1S/C16H14F3N3O3S/c1-9-13(20-5-4-14(9)25-8-16(17,18)19)7-26(24)15-21-11-3-2-10(23)6-12(11)22-15/h2-6,23H,7-8H2,1H3,(H,21,22)
InChI Key:
IDCLTMRSSAXUNY-UHFFFAOYSA-N
Properties
Complexity:
511  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
385.071g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
385.361g/mol
Monoisotopic Mass:
385.071g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood. European journal of clinical pharmacology 20120501
Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects. Xenobiotica; the fate of foreign compounds in biological systems 20110601
Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers. Journal of pharmaceutical and biomedical analysis 20081201
Lack of significant effect of grapefruit juice on the pharmacokinetics of lansoprazole and its metabolites in subjects with different CYP2C19 genotypes. Journal of clinical pharmacology 20050601
Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. European journal of clinical pharmacology 20041101
Properties