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Pindolol

CAS No.:
13523-86-9
Catalog Number:
AG009AFB
Molecular Formula:
C14H20N2O2
Molecular Weight:
248.3208
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
50mg
98%
In Stock USA
United States
$212
- +
100mg
98%
In Stock USA
United States
$261
- +
250mg
98%
In Stock USA
United States
$403
- +
500mg
98%
In Stock USA
United States
$593
- +
Product Description
Catalog Number:
AG009AFB
Chemical Name:
Pindolol
CAS Number:
13523-86-9
Molecular Formula:
C14H20N2O2
Molecular Weight:
248.3208
MDL Number:
MFCD00010530
IUPAC Name:
1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
InChI:
InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
InChI Key:
JZQKKSLKJUAGIC-UHFFFAOYSA-N
SMILES:
OC(COc1cccc2c1cc[nH]2)CNC(C)C
EC Number:
236-867-9
NSC Number:
757276
Properties
Complexity:
248  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
248.152g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
248.326g/mol
Monoisotopic Mass:
248.152g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
57.3A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8  
Literature
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Serotonergic mediation of constant light-potentiated nonphotic phase shifting of the circadian locomotor activity rhythm in Syrian hamsters. American journal of physiology. Regulatory, integrative and comparative physiology 20060701
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Enantiomeric separation and quantification of pindolol in human plasma by chiral liquid chromatography/tandem mass spectrometry using staggered injection with a CTC Trio Valve system. Rapid communications in mass spectrometry : RCM 20060101
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A mathematical model for paroxetine antidepressant effect time course and its interaction with pindolol. Journal of pharmacokinetics and pharmacodynamics 20051201
Combination/augmentation strategies for improving the treatment of depression. Neuropsychiatric disease and treatment 20051201
Positive inotropic and lusitropic effects mediated via the low-affinity state of beta1-adrenoceptors in pithed rats. British journal of pharmacology 20051101
Open trial of pindolol in the treatment of fibromyalgia. The Annals of pharmacotherapy 20051101
Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388. Chest 20051001
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Use of vancomycin chiral stationary phase for the enantiomeric resolution of basic and acidic compounds by nano-liquid chromatography. Journal of chromatography. A 20050715
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Evidence for the activity of lamotrigine at 5-HT(1A) receptors in the mouse forced swimming test. Journal of psychiatry & neuroscience : JPN 20050701
Effect of various antagonists on the Channa striatus fillet extract antinociception in mice. Canadian journal of physiology and pharmacology 20050701
Different structural requirements for the constitutive and the agonist-induced activities of the beta2-adrenergic receptor. The Journal of biological chemistry 20050624
Evidence for the presence of beta-3-adrenoceptors mediating relaxation in the human oviduct. Pharmacology 20050601
Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology 20050601
Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. Journal of pharmaceutical sciences 20050601
Isoproterenol reduces ischemia-reperfusion lung injury despite beta-blockade. The Journal of surgical research 20050601
Acute tryptophan depletion in depressed patients treated with a selective serotonin-noradrenalin reuptake inhibitor: augmentation of antidepressant response? Journal of affective disorders 20050601
Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues in clinical neuroscience 20050601
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol. European journal of pharmacology 20050509
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry 20050505
Pindolol augmentation of selective serotonin reuptake inhibitors: accounting for the variability of results of placebo-controlled double-blind studies in patients with major depression. Human psychopharmacology 20050401
Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats. Autonomic neuroscience : basic & clinical 20050331
Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol. European journal of pharmacology 20050321
HPLC and solubility study of the interaction between pindolol and cyclodextrins. Journal of pharmaceutical and biomedical analysis 20050309
Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors. The Journal of pharmacology and experimental therapeutics 20050301
Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]. The Journal of pharmacology and experimental therapeutics 20050301
Candidate genes for antidepressant response to selective serotonin reuptake inhibitors. Neuropsychiatric disease and treatment 20050301
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Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry 20050127
Quantitative analysis of beta-blockers in pharmaceutical preparations by capillary electrophoresis. Drug development and industrial pharmacy 20050101
Adrenergic receptor modulation of hippocampal CA3 network activity. Epilepsy research 20050101
Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples. Rapid communications in mass spectrometry : RCM 20050101
Potentiation strategies for treatment-resistant depression. Acta psychiatrica Scandinavica. Supplementum 20050101
Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. The international journal of neuropsychopharmacology 20041201
Synthesis of some N-substituted aminoalkanol derivatives of 5,8-dimethyl-3b,9-epoxy-3a,4,5,6,7,8,9,9a-octahydro-1H-benzo[e]isoindole-1,3(2H)-dione and 6,7-dimethyl-4,9-epoxy-3a,4,5,8,9,9a-hexahydro-1H-benzo[f]isoindole-1,3(2H)-dione with an expected b-adrenolytic activity. Acta poloniae pharmaceutica 20041201
Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol. International journal of pharmaceutics 20041105
Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats. British journal of pharmacology 20041101
Review: combining pindolol with an SSRI improves early outcomes in people with depression. Evidence-based mental health 20041101
Usefulness of pindolol for treatment of neurocardiogenic syncope. The American journal of cardiology 20041101
Therapeutic alternatives for difficult-to-treat depression: a narrative review of the state of the evidence. CNS spectrums 20041101
[Pindolol determination in pharmaceuticals by the method of capillary isotachophoresis]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20041101
Anxiolytic-like effects of extracts from Albizzia julibrissin bark in the elevated plus-maze in rats. Life sciences 20041022
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain research 20041015
Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040901
[18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040901
Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice. European journal of pharmacology 20040830
Modulatory effects on myocardial physiology induced by an anti-Trypanosoma cruzi monoclonal antibody involve recognition of major antigenic epitopes from beta1-adrenergic and M2-muscarinic cholinergic receptors without requiring receptor cross-linking. Journal of neuroimmunology 20040801
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn-Schmiedeberg's archives of pharmacology 20040801
Enantioselectivity of structurally modified poly(sodium undecenoyl-L-leucinate) by insertion of Triton X-102 surfactant molecules. Electrophoresis 20040801
Enantioseparations by capillary electro-chromatography: differences exhibited by normal- and reversed-phase versions of polysaccharide stationary phases. Electrophoresis 20040801
Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. European journal of pharmacology 20040714
Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol. Journal of controlled release : official journal of the Controlled Release Society 20040707
Opposing electrophysiological actions of 5-HT on noncholinergic and cholinergic neurons in the rat ventral pallidum in vitro. Journal of neurophysiology 20040701
Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding. European journal of medicinal chemistry 20040701
The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. Journal of psychiatry & neuroscience : JPN 20040701
ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. British journal of pharmacology 20040601
Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms. Pharmacogenetics 20040601
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. Journal of psychopharmacology (Oxford, England) 20040601
An indomethacin-sensitive contraction induced by beta-antagonists in guinea pig airways. Canadian journal of physiology and pharmacology 20040601
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex. The Journal of physiology 20040501
Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Naunyn-Schmiedeberg's archives of pharmacology 20040501
Pindolol does not augment cortisol and prolactin responses to paroxetine in healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry 20040501
Simultaneous determination of thirteen beta-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection. Forensic science international 20040420
Effectiveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomised controlled trials. Journal of affective disorders 20040401
An autoradiographic study of the influence of pindolol upon [35S]GTPgammaS binding in rat, guinea pig and human brain. The international journal of neuropsychopharmacology 20040301
Serotonin modulates hypothalamic neuronal activity. The International journal of neuroscience 20040301
Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040301
Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors. Journal of psychiatry & neuroscience : JPN 20040301
Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors. Biochemical pharmacology 20040301
Current perspectives in the management of treatment-resistant depression. Dialogues in clinical neuroscience 20040301
Once-daily high-dose pindolol for SSRI-refractory depression. Psychiatry research 20040215
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology 20040201
Differences in beta-adrenergic receptor densities in omental and subcutaneous adipose tissue from obese African American and Caucasian women. Metabolism: clinical and experimental 20040201
Indirect resolution of beta-blocker agents by reversed-phase capillary electrochromatography. Electrophoresis 20040201
Pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitors: a double-blind, randomized, controlled trial. The Journal of clinical psychiatry 20040201
Attenuation of the effects of fluoxetine on serotonergic neuronal activity by pindolol in rats. Neuroscience letters 20040123
Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors. Behavioural brain research 20040105
Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors. Neuroscience 20040101
Cardiovascular events in elderly patients with isolated systolic hypertension. A subgroup analysis of treatment strategies in STOP-Hypertension-2. Blood pressure 20040101
Enteral drug absorption in patients with short small bowel : a review. Clinical pharmacokinetics 20040101
Neural network analysis in pharmacogenetics of mood disorders. BMC medical genetics 20040101
Vitamin B2-sensitised photooxidation of the ophthalmic drugs Timolol and Pindolol: kinetics and mechanism. Redox report : communications in free radical research 20040101
Response to treatment during medium-term follow-up in a series of patients with neurocardiogenic syncope. Archives of medical research 20040101
Distribution of catecholaminergic neurotransmitters and related receptors in human bronchus-associated lymphoid tissue. Respiration; international review of thoracic diseases 20040101
Determination of bopindolol using the flow injection technique coupled with solid phase extraction. Journal of pharmaceutical and biomedical analysis 20031204
Functional mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule. American journal of physiology. Renal physiology 20031201
Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors. Naunyn-Schmiedeberg's archives of pharmacology 20031201
Milnacipran and pindolol: a randomized trial of reduction of antidepressant latency. Human psychopharmacology 20031201
Chronobiology and mood disorders. Dialogues in clinical neuroscience 20031201
Sleep deprivation and antidepressant treatment. Dialogues in clinical neuroscience 20031201
Determination of bopindolol by sequential injection technique with spectrophotometric detection. Farmaco (Societa chimica italiana : 1989) 20031001
Effect of pindolol and milnacipran versus milnacipran and placebo on plasma prolactin and adrenocorticotrophic hormone in depressed subjects. Human psychopharmacology 20031001
Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924. Naunyn-Schmiedeberg's archives of pharmacology 20030901
Evaluation of teicoplanin chiral stationary phases of 3.5 and 5 microm inside diameter silica microparticles by polar-organic mode capillary electrochromatography. Electrophoresis 20030901
Obsessive-compulsive spectrum disorders. Dialogues in clinical neuroscience 20030901
Pindolol and the acceleration of the antidepressant response. Journal of affective disorders 20030801
Separation of basic drug enantiomers by capillary electrophoresis using chicken alpha1-acid glycoprotein: insight into chiral recognition mechanism. Electrophoresis 20030801
Improvement of peak shape and separation performance of beta-blockers in conventional reversed-phase columns using solvent modifiers. Journal of chromatographic science 20030801
Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol. Die Pharmazie 20030801
Comparison of frequency of recurrent syncope after beta-blocker therapy versus conservative management for patients with vasovagal syncope. The American journal of cardiology 20030701
Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function. European journal of applied physiology 20030601
Agonist actions of 'beta-blockers' provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. Molecular pharmacology 20030601
Restricted access media-molecularly imprinted polymer for propranolol and its application to direct injection analysis of beta-blockers in biological fluids. The Analyst 20030601
Psychiatric side effects of medications prescribed in internal medicine. Dialogues in clinical neuroscience 20030601
Acceleration and augmentation strategies for treating bipolar depression. Biological psychiatry 20030415
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy). The Journal of pharmacology and experimental therapeutics 20030401
Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European journal of pharmacology 20030319
Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers. Psychopharmacology 20030301
EEG effects of buspirone and pindolol: a method of examining 5-HT1A receptor function in humans. Psychopharmacology 20030301
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology 20030301
The pharmacology of putative early-onset antidepressant strategies. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030301
SSRIs antidepressant activity is influenced by G beta 3 variants. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030301
Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo. Neuropharmacology 20030201
Chiral separation of amines with N-benzoxycarbonylglycyl-L-proline as selector in non-aqueous capillary electrophoresis using methanol and 1,2-dichloroethane in the background electrolyte. Journal of chromatography. A 20030117
Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor. Pharmacology, biochemistry, and behavior 20030101
Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta. British journal of pharmacology 20030101
Pharmacological management for agitation and aggression in people with acquired brain injury. The Cochrane database of systematic reviews 20030101
[Interest of the use of pindolol in the treatment of depression: review]. L'Encephale 20030101
Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor. Brain research. Developmental brain research 20021215
The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021201
Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology 20021201
Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats. Brain research 20021108
Spin trapping study of reactive oxygen species formation during bopindolol peroxidation. Biopolymers 20021015
Singlet molecular oxygen generation and quenching by the antiglaucoma ophthalmic drugs, Timolol and Pindolol. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20021001
Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling. Molecular pharmacology 20020901
Psychopharmacology of anxiety disorders. Dialogues in clinical neuroscience 20020901
Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. Brain, behavior, and immunity 20020801
Melatonin potentiates 5-HT(1A) receptor activation in rat hypothalamus and results in hypothermia. Journal of pineal research 20020801
Enantioselectivity in the steady-state pharmacokinetics and transplacental distribution of pindolol at delivery in pregnancy-induced hypertension. Chirality 20020801
Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons. Journal of neurophysiology 20020801
[Reactions between dialkylamine drugs, 2,3-dichloro-1,4-naphthoquinone and acetaldehyde]. Die Pharmazie 20020801
[Pharmacology of beta blockers and their significance for therapy of hypertension]. Herz 20020801
Synthesis and evaluation of (S)-[18F]-fluoroethylcarazolol for in vivo beta-adrenoceptor imaging in the brain. Neurochemistry international 20020701
Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. The Journal of pharmacology and experimental therapeutics 20020701
5-HT1A receptor blockade and the motivational profile of ethanol. Life sciences 20020628
Management of treatment resistant obsessive-compulsive disorder. Algorithms for pharmacotherapy. Panminerva medica 20020601
[Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20020601
The neuropharmacology of serotonin and noradrenaline in depression. International clinical psychopharmacology 20020601
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020525
Determination of bopindolol in pharmaceuticals by capillary isotachophoresis. Journal of pharmaceutical and biomedical analysis 20020515
Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Direct determination of pindolol enantiomers in human serum by column-switching LC-MS/MS using a phenylcarbamate-beta-cyclodextrin chiral column. Journal of pharmaceutical and biomedical analysis 20020401
Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacology, biochemistry, and behavior 20020401
Copper(II) complexes of the beta-blocker pindolol: properties, structure, biological activity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20020301
Pharmacokinetic scaling of pindolol in healthy volunteers after single dose oral administration. Methods and findings in experimental and clinical pharmacology 20020301
Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity. The international journal of neuropsychopharmacology 20020301
Pathophysiology of depression and mechanisms of treatment. Dialogues in clinical neuroscience 20020301
Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET. Neurochemistry international 20020201
Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. Pharmacology 20020201
Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex. European journal of pharmacology 20020201
Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Combinatorial chemistry & high throughput screening 20020201
PET-examination and metabolite evaluation in monkey of [(11)C]NAD-299, a radioligand for visualisation of the 5-HT(1A) receptor. Nuclear medicine and biology 20020101
Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. British journal of pharmacology 20020101
Imaging the neurochemical brain in health and disease. Clinical medicine (London, England) 20020101
Familial left ventricular hypertrabeculation in two blind brothers. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20020101
Influence of antihypertensive treatment with perindopril, pindolol or felodipinon plasma leptin concentration in patients with essential hypertension. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020101
Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats. Polish journal of pharmacology 20020101
Influence of various biological matrices (plasma, blood microdialysate) on chromatographic performance in the determination of beta-blockers using an alkyl-diol silica precolumn for sample clean-up. Journal of chromatography. B, Biomedical sciences and applications 20011225
Imaging of beta-adrenoceptors in the human thorax using (S)-[(11)C]CGP12388 and positron emission tomography. European journal of pharmacology 20011221
Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low. The American journal of psychiatry 20011201
Further characterization of beta3-adrenoceptors in the guinea pig gastric fundus: stereoselectivity, beta-adrenoceptor alkylation, and structure-activity relationship. Canadian journal of physiology and pharmacology 20011201
No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors. Psychiatry research 20011130
Sympathomimetic effects of pindolol in depression. Trends in pharmacological sciences 20011101
Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology 20011101
Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices. Journal of neurochemistry 20011101
On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor. Brain research 20011012
Pindolol potentiation of paroxetine for generalized social phobia: a double-blind, placebo-controlled, crossover study. The American journal of psychiatry 20011001
Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001
The 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT) induces hyperglucagonemia in rats. Biological & pharmaceutical bulletin 20011001
Chiral separation of beta-blockers after derivatization with (-)-alphamethoxy-alpha-(trifluoromethyl)phenylacetyl chloride by gas chromatography. Archives of pharmacal research 20011001
Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Molecular psychiatry 20010901
Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression. Biological psychiatry 20010901
Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein. Electrophoresis 20010901
Quasi-irreversible binding of agonist to beta-adrenoceptors and formation of non-dissociating receptor-G(s) complex in the absence of guanine nucleotides. European journal of pharmacology 20010817
Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. Journal of neurochemistry 20010801
Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits. Current eye research 20010801
Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase. European journal of pharmacology 20010713
Is the beneficial antidepressant effect of coadministration of pindolol really due to somatodendritic autoreceptor antagonism? Biological psychiatry 20010701
The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). European journal of pharmacology 20010615
Experimental and computational screening models for the prediction of intestinal drug absorption. Journal of medicinal chemistry 20010607
New methods for the isolation of skeletal muscle sarcolemma and sarcoplasmic reticulum allowing a comparison between the mammalian and amphibian beta(2)-adrenergic receptors and calcium pumps. Cell biochemistry and function 20010601
Characterization of sarcolemma and sarcoplasmic reticulum isolated from skeletal muscle of the freeze tolerant wood frog, Rana sylvatica: the beta(2)-adrenergic receptor and calcium transport systems in control, frozen and thawed states. Cell biochemistry and function 20010601
Effect of lipophilicity on in vivo iontophoretic delivery. II. Beta-blockers. Biological & pharmaceutical bulletin 20010601
Simultaneous administration of a cocktail of markers to measure renal drug elimination pathways: absence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and pindolol. British journal of clinical pharmacology 20010601
The 'dalhousie serotonin cocktail' for treatment-resistant major depressive disorder. Journal of psychopharmacology (Oxford, England) 20010601
An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology 20010601
Trimetazidine for stable angina pectoris. Expert opinion on pharmacotherapy 20010501
How does pindolol improve antidepressant action? Trends in pharmacological sciences 20010501
Quantifying drug-related 5-HT1A receptor occupancy with. Psychopharmacology 20010501
Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study. European journal of pharmacology 20010420
Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents. Brain research 20010413
Quantitative structure-retention and retention-activity relationships of beta-blocking agents by micellar liquid chromatography. Journal of chromatography. A 20010406
Roles of 5-HT receptors in the release and action of secretin on pancreatic secretion in rats. American journal of physiology. Gastrointestinal and liver physiology 20010401
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Pharmacology of rapid-onset antidepressant treatment strategies. The Journal of clinical psychiatry 20010101
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The effects of 5-HT1A receptor agonists, 5-HT1A receptor antagonists and their interaction on the fear-potentiated startle response. Psychopharmacology 19981001
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Naunyn-Schmiedeberg's archives of pharmacology 19980301
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Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Archives internationales de pharmacodynamie et de therapie 19960101
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Chronic effects of metoprolol on myocardial beta-adrenergic receptors in doxorubicin-induced cardiac damage in rats. Journal of cardiovascular pharmacology 19910401
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Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America 19881201
Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs. The Journal of pharmacy and pharmacology 19881201
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Effect of altered plasma protein binding on pharmacokinetics and pharmacodynamics of propranolol in rats after surgery: role of alpha-1-acid glycoprotein. The Journal of pharmacology and experimental therapeutics 19851101
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Parkinson's disease on treatment with Viskaldix. The Journal of the Royal College of General Practitioners 19840301
In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, in various animals. Arzneimittel-Forschung 19840101
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Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. Australian and New Zealand journal of medicine 19820801
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