Home Other Building Blocks CGP 42112

CGP 42112

CAS No.:
127060-75-7
Catalog Number:
AG009ADU
Molecular Formula:
C52H69N13O11
Molecular Weight:
1052.1848
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$273
- +
5mg
99%
1 week
United States
$800
- +
Product Description
Catalog Number:
AG009ADU
Chemical Name:
CGP 42112
CAS Number:
127060-75-7
Molecular Formula:
C52H69N13O11
Molecular Weight:
1052.1848
MDL Number:
MFCD00133611
IUPAC Name:
(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-2-[[(2S)-3-(4-hydroxyphenyl)-2-(pyridine-3-carbonylamino)propanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
InChI:
InChI=1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1
InChI Key:
UXGNARZDONUMMK-LRMQDCNJSA-N
SMILES:
CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccc(cc1)O)CCCCNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCNC(=N)N)Cc1nc[nH]c1)C
Properties
Complexity:
1930  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
0
Exact Mass:
1051.524g/mol
Formal Charge:
0
Heavy Atom Count:
76  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
11  
Isotope Atom Count:
0
Molecular Weight:
1052.204g/mol
Monoisotopic Mass:
1051.524g/mol
Rotatable Bond Count:
30  
Topological Polar Surface Area:
368A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells. Neurotoxicology and teratology 20150101
Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979) 20120901
Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway. Regulatory peptides 20120820
Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway. Pharmacological research 20120701
Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1. American journal of physiology. Heart and circulatory physiology 20120615
Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats. Journal of hypertension 20120601
Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clinical science (London, England : 1979) 20111001
Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats. American journal of physiology. Heart and circulatory physiology 20111001
Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation. BMC cancer 20110101
Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. American journal of physiology. Renal physiology 20101001
Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter. Neuroscience 20091215
Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. American journal of physiology. Heart and circulatory physiology 20090301
Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure. Hypertension (Dallas, Tex. : 1979) 20081001
Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertension research : official journal of the Japanese Society of Hypertension 20080901
Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts. Journal of cardiovascular pharmacology 20080801
Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye. Investigative ophthalmology & visual science 20080601
Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats. Pharmacology, biochemistry, and behavior 20071001
Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease. Journal of cardiovascular pharmacology 20071001
Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Molecular endocrinology (Baltimore, Md.) 20070201
Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. American journal of physiology. Renal physiology 20060601
Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension (Dallas, Tex. : 1979) 20060601
Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. Metabolism: clinical and experimental 20060401
A non-radioactive method for angiotensin II receptor binding studies using the rat liver. Journal of pharmacological and toxicological methods 20060101
Dynamic expression of the angiotensin II type 2 receptor and duodenal mucosal alkaline secretion in the Sprague-Dawley rat. Experimental physiology 20060101
Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats. Journal of hypertension 20060101
Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance. Regulatory peptides 20051215
Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats. Journal of hypertension 20051201
Nitric oxide contributes to AT2 but not AT1 angiotensin II receptor-mediated vasodilatation of porcine pial arteries and arterioles. European journal of pharmacology 20051121
The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice. Journal of cardiovascular pharmacology 20050901
Angiotensin II infusion increases hepatic triglyceride production via its type 2 receptor in rats. Journal of hypertension 20050801
Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture. Journal of leukocyte biology 20050701
Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression. Cardiovascular drugs and therapy 20050301
Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension (Dallas, Tex. : 1979) 20050201
A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception. Neuroscience 20050101
Minocycline treatment attenuates microglia activation and non-angiotensin II [125I] CGP42112 binding in brainstem following nodose ganglionectomy. Neuroscience 20050101
AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR. British journal of pharmacology 20040701
Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area. Regulatory peptides 20040515
Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat. Autonomic neuroscience : basic & clinical 20040331
Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Molecular endocrinology (Baltimore, Md.) 20040301
Effects of subtypes of adrenergic and angiotensinergic antagonists on the water and sodium intake induced by adrenaline injected into the paraventricular nucleus. Brain research 20031224
Angiotensin II mediates Tyr-dephosphorylation in rat fetal kidney membranes. Molecular and cellular biochemistry 20031201
Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells. Hypertension research : official journal of the Japanese Society of Hypertension 20031101
Effects of V1 and angiotensin receptor subtypes of the paraventricular nucleus on the water intake induced by vasopressin injected into the lateral septal area. Brain research bulletin 20030930
Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells. Circulation research 20030905
Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits. Hypertension (Dallas, Tex. : 1979) 20030801
Angiotensin II and III microinjections into the zona incerta influence drinking behavior. Brain research 20030711
Localization of AT(2) receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy. Brain research 20030404
The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa. BMC pharmacology 20030101
AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension (Dallas, Tex. : 1979) 20021001
Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundamental & clinical pharmacology 20020801
Effects of angiotensin II microinjected into medial amygdala on male sexual behavior in rats. Hormones and behavior 20020501
Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells. The Journal of endocrinology 20020501
Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Hypertension (Dallas, Tex. : 1979) 20011201
Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia. The Journal of endocrinology 20011001
Differential regulation of thrombospondin-1 and fibronectin by angiotensin II receptor subtypes in cultured endothelial cells. Cardiovascular research 20010901
Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure. Hypertension (Dallas, Tex. : 1979) 20010901
Identification of angiotensin II type 2 (AT2) receptor domains mediating high-affinity CGP 42112A binding and receptor activation. The Journal of pharmacology and experimental therapeutics 20010801
Activation of angiotensin II subtype 2 receptor induces catecholamine release in an extracellular Ca(2+)-dependent manner through a decrease of cyclic guanosine 3',5'-monophosphate production in cultured porcine adrenal medullary chromaffin Cells. Endocrinology 20010701
Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat. American journal of physiology. Gastrointestinal and liver physiology 20010601
Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin II infusion. Journal of hypertension 20010601
Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. British journal of pharmacology 20010401
Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney international 20001201
Human angiotensin receptor subtypes. Current opinion in nephrology and hypertension 19940101
Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors. Biochemical and biophysical research communications 19911231
Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochemical and biophysical research communications 19890830
Properties